Covalent drugs have emerged as a groundbreaking modality for improving the affinity, potency, and duration of action of molecularly targeted inhibitors. Prof. ... Read more

A major challenge in developing viral-based therapies, such as gene therapies, CAR-T cell immunotherapy, and oncolytic virotherapy, is that the most efficient vectors and viruses are not specific, preventing their direct administration to the patient. Prof. ... Read more

Serum albumins are essential in a wide variety of molecular and cellular applications, including in the medical, biotechnological and cultivated meat industries. ... Read more

Enveloped viruses pose significant health risks and lack effective treatments. Inhibiting viral membrane fusion, a crucial step in infection, holds promise for antiviral drug development. Dr. ... Read more

Myocardial infarction (MI), commonly known as a heart attack, is a leading cause of death worldwide, with no available therapies for restoring heart function post-MI. Prof. ... Read more

Ovarian cancer is the fifth leading cause of cancer-related death in women. Due to a lack of early detection methods, it is often diagnosed at a late stage, resulting in negligible changes to cure. ... Read more

Acute myeloid leukemia  (AML) incidents increases with age and mortality exceeds 90% when it is diagnosed after the age of 65. Specific mutations were shown to exist in pre-leukemic subjects years before the disease breaks. ... Read more

Psychiatric disorders, especially major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. Prof. ... Read more

Of the approximately 30 million adult smokers in the U.S, more than half report attempting to quit smoking every year. However, smoking cessation-associated weight gain (SCWG) constitutes a major obstacle to smoking withdrawal. ... Read more

Ewing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis. ... Read more