Chimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science. ... Read more

A novel gut microbiome-based method has been developed to predict and prevent weight regain after weight loss. ... Read more

Antibiotic-resistant bacteria such as Staphylococcus aureus (MRSA) are a growing threat, causing severe infections that are increasingly untreatable by existing drugs. This technology provides a high-resolution crystal structure of the large ribosomal subunit (50S) from pathogenic S. ... Read more

Chronic lung infections, especially in cystic fibrosis (CF) patients, are increasingly difficult to manage due to rising antibiotic resistance. ... Read more

TCR gene therapies show promise in cancer treatment but are hindered by the low natural avidity of TCRs against tumor-associated antigens. MAGE-A1 is a germline antigen expressed in many tumor types, making it a compelling target for TCR-based immunotherapy. ... Read more

A novel therapeutic strategy for Amyotrophic Lateral Sclerosis (ALS) targets impaired microRNA (miRNA) biogenesis—a key molecular defect found in both sporadic and familial ALS. ... Read more

ADAM17 is a metalloprotease that regulates shedding of membrane-bound proteins, including IL-6, TNF-α, and others. ADAM17 is implicated in inflammatory diseases, fibrosis, cancer, and autoimmune conditions, making it a compelling target. ... Read more