BioPlatforms(6)
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Computationally Designed Peroxygenases for Selective Terpene Oxyfunctionalization (No. T4-2403)
Terpenes represent the largest class of secondary plant metabolites. Their oxyfunctionalized derivatives, terpenoids, are widely used in the pharmaceutical, flavor, and fragrance industries due to their aromatic properties. ... Read more19149 -
Polymerization-Inducing Chimeras (PINCH) for Selective Target Inactivation (No. T4-2323)
A novel modality for selectively inactivating homomeric proteins, common in disease-driving pathways, by inducing their polymerization. ... Read more19253 -
High Throughput Screening Platform For Inhibitors of Viral Membrane Fusion (No. T4-2213)
Emerging and re-emerging enveloped viruses, such as SARS-CoV-2, influenza, Nipah, and Ebola, continue to pose serious global health threats, with limited treatment options. ... Read more18679 -
Covalent Chemistry Platform for Diagnostics and Drug Discovery (No. T4-2045)
CoLDR (Covalent Ligand-Directed Release) chemistry enables site-specific covalent labeling and activation of endogenous proteins using small-molecule covalent ligands. ... Read more6106 -
Safer CAR-T Cell Platform (No. T4-2033)
Chimeric Antigen Receptor (CAR)-T Cell Therapy is a personalized treatment for cancer in which the patient's T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. ... Read more6124 -
A Method to Identify Actively Degraded Proteins (No. T4-1832)
MAPP (Mass Spectrometry Analysis of Proteolytic Peptides) is a groundbreaking technology that isolates and identifies proteins actively degraded by the proteasome, offering an unparalleled and direct view of the "active degradome." This innovative approach provides a sensitive an ... Read more6030
