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Therapeutic targeting of senescent cells

Technology Number: 

1825

Principal Investigator

Ph.D.
Valery
Krizhanovsky

Department: 

Molecular Cell Biology
Summary 

Senescence is a form of cell-cycle arrest which occurs in many cell types. Cellular senescence can reduce tissue damage and tumorigenesis; however long-term induction of senescence promotes fibrosis, metastasis, inflammation, tissue damage and tissue aging. Senescent cells are known to be involved in many disorders and pathologies – from cancer to hair loss. Identification and elimination of senescent cells may thus be beneficial for a variety of diseases.

Prof. Krizhanovsky and his team performed clever proteomic studies and discovered surface markers that are unique to senescent cells of the fibrotic tissue. These cell surface markers which differentiate senescent cells from non-senescent cells can be utilized for antibody mediated elimination of these cells, with the goal of treating fibrotic disease.

 

Applications


* Novel cell surface markers of senescent cells

* Treat senescence-related diseases

 


Advantages


Prof. Krizhanovsky's team induced senescence in vitro by DNA damage (DIS) or oncogenes (OIS) and explored proteins expressed on these senescent cells by mass spectrometry. Then a panel of cell-surface proteins which identified the senescent cells was assembled and verified in vivo. Among these proteins, protein "X" was further studied and found to be senescent-cell specific. The group currently attempts to determine its biological role and develop a targeting antibody to protein “X”.

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