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Rotating Field Transcranial Magnetic Stimulation (rfTMS)

Technology Number: 

1540

Principal Investigator

Prof.
Elisha
Moses

Department: 

Physics of Complex Systems

Patent Status: 

Granted US 9067052; 9770601
Summary 

A novel TMS method that eliminates the restrictions of angular positioning, exciting more neurons per area of stimuli, in further areas of the brain.

 

Current TMS methods and TMS methods under development, suffer shortcomings of a highly specific directional electric field, which demands a precisely targeted application. Current methods are extremely sensitive to the movements of the patient or the device. Once a position is established the patient must remain still for the treatment. Furthermore, stable and reproducible positioning is costly and time-consuming.

 

Researchers at the Weizmann Institute developed a method to induce a rotating magnetic field in TMS applications, yielding optimal targeting of brain regions where correct orientation cannot be determined (e.g. via motor feedback). This innovative method can also stimulate brain regions with no preferred axonal orientation, and open new applications in diagnostics and research in neuronal cultures and rats, previously unresponsive to conventional TMS.

Applications


  • Accurate, cost-effective, enhanced rfTMS devices for treatment of depression, migraines and other mental disorders.
  • A novel model system in rats and neuronal cultures for development of diagnostics and therapeutics.

Advantages


  • Exciting more neurons in the same area of stimulation
  • Accessing areas in the brain that are currently unresponsive to conventional TMS.
  • No positional restrictions
  • Requires less voltage

Technology's Essence


The theory behind this technology involves the understanding that neural response is direction dependent. Neurons whose axons are parallel to the magnetic field will be most significantly stimulated. Additionally, factors of magnetic field, rise time and neural cooperatively play a role. All these are addressed by a rotating magnetic field creating anisotropy of angles that match the neurons’ orientation and the excitation of dendrites by applying pulses of the order of 1ms. This solution offers greater control over the TMS system.

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