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138
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and progesterone-11- hemisuccinate-BSA (clone 1E11, IgG1).
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Reference: Jozef G. De Boever, Fotune Kohen, Eugene Bosmans. 1994.  Binding of homologous and heterologous isoluminol- and enzyme-labelled  progesterone conjugates to monoclonal antibodies. Analytica Chimica Acta.  290: 239-245

 

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  138,146 – Monoclonal antibodies to Progesterone          

      Description:  Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and progesterone-11- hemisuccinate-BSA (clone 1E11, IgG1).

Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.

      Reference: Jozef G. De Boever, Fotune Kohen, Eugene Bosmans. 1994.      Binding of homologous and heterologous isoluminol- and enzyme-labelled   progesterone conjugates to monoclonal antibodies. Analytica Chimica Acta.    290: 239-245


 

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  • Dr. Fortune Kohen
186
A DNP-specific murine IgE monoclonal antibody Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody...

A DNP-specific murine IgE monoclonal antibody

Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody binds to mast cells or rat basophilic leukemia cells and, upon binding of DNP-protein, triggers an anaphylactic reaction.

Reference: Eshhar Z, Ofarim M, Waks T. 1980. Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. J Immunol 124(2):775-80.

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  • Prof. Zelig Eshhar
259
259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr. Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin...

259 - Monoclonal antibody to Caspr

Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr.

Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin sheath attachment along with contactin. May be glycosylated.

Reference: Poliak S1, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E. 1999. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Neuron. 24(4):1037-47.

 

Tech # 1269

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  • Prof. Elior Peles
117
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Drugs: §  117 – Monoclonal antibody to Digoxin         Description: Rat...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Drugs:

§  117 – Monoclonal antibody to Digoxin

        Description: Rat monoclonal antibodies raised against Digoxin.

        Available clone: 10F10, IgG1.

Digoxin is a purified cardiac glycoside similar to Digitoxin extracted from the foxglove plant, Digitalis lanata. Digoxin is widely used in the treatment of various heart conditions.

 
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  • Dr. Fortune Kohen
173
181 - Monoclonal antibody to Galectin-8 Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer...

181 - Monoclonal antibody to Galectin-8

Description: Monoclonal antibody to Galectin-8 (clone 106.1).

Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer.  It was shown to trigger the transcription of a unique set of genes, some of which are associated with bone remodeling and prostate cancer progression.

Reference: Levy Y, Arbel-Goren R, Hadari YR, Eshhar S, Ronen D, Elhanany E, Geiger B, Zick Y. 2001. Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem. 276(33):31285-95.

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288
hVin monoclonal antibody Description: Monoclonal antibodies raised against human Vinculin purified from human uterus. Specifically stains Vinculin at cell-cell and cell-substrate contacts in tissue and cultured cells. Good reactivity is obtained with human, bovine, chicken, dog, rat mouse, turkey and...

hVin monoclonal antibody

Description: Monoclonal antibodies raised against human Vinculin purified from human uterus. Specifically stains Vinculin at cell-cell and cell-substrate contacts in tissue and cultured cells. Good reactivity is obtained with human, bovine, chicken, dog, rat mouse, turkey and xenopus Vinculin.

Vinculin is a cytoskeletal protein associated with the cytoplasmic faces of both cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of

several interacting proteins involved in anchoring F-actin to the membrane.

Reference: Geiger B, Volk T, Volberg T, Bendori R. 1987. Molecular interactions in adherens-type contacts. J Cell Sci Suppl.8:251-72.

Applications


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  • Prof. Benjamin Geiger
142
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Biotin: §  116, 142 – Monoclonal antibody to Biotin            Description: Monoclonal...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Biotin:

§  116, 142 – Monoclonal antibody to Biotin

           Description: Monoclonal antibodies raised against biotinylated BSA.

           Available clones: F1, F4.

Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). Functions as coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.

Reference: Bag?i H1, Kohen F, Kus?uoglu U, Bayer EA, Wilchek M. 1993. Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin. FEBS Lett. 322(1):47-50.

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  • Dr. Fortune Kohen
237
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides...

236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis

Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both D- and L amino acids (diastereomers). These peptides have demonstrated potent anti-cancer and anti metastatic activities in several animal models including models for prostate and lung cancer. They were shown to successfully inhibit tumor growth when injected intratumorally or intraveneously. The 15-mer Histidine form shows reduced systemic toxicity.

References: Papo N, Braunstein A, Eshhar Z, Shai Y. 2004. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16):5779-86.

Makovitzki A1, Fink A, Shai Y. 2009. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res. 69(8):3458-63.

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  • Prof. Yechiel Shai
263
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains...

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes.
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes.
Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

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  • Prof. Lia Addadi
119
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.
Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.
Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Steroid Hormones:

§  119, 169 – Monoclonal antibodies to Testosterone          

      Description: Rat monoclonal antibodies raised against testosterone 3-(0-   carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.

Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.

Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.


 

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  • Dr. Fortune Kohen
177
176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the...

176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase

Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115).

ERK belongs to the family of mitogen-activated protein kinases (MAPKs) and is an important component in many intracellular signaling events. ERK is phosphorylated and activated by the upstream kinases, MEK1 and MEK2 on regulatory Threonin (Thr) and tyrosine (Tyr) residues, which are localized in the activation loop of ERK.

Reference: Yao Z, Dolginov Y, Hanoch T, Yung Y, Ridner G, Lando Z, Zharhary D, Seger R. 2000. Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases. FEBS Lett. 468(1):37-42.

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  • Prof. Rony Seger

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