You are here

Category
Technology Name
Briefcase
Scientist
238
238 - CP Peptide Description: Core peptide (CP; GLRILLLKV-D-stereoisomer), a synthetic peptide coding for the transmembrane domain of the ?-subunit of the T-cell receptor (TCR), a region that has been identified to be crucial for the assembly and function of the TCR. Was shown to significantly inhibit...

238 - CP Peptide

Description: Core peptide (CP; GLRILLLKV-D-stereoisomer), a synthetic peptide coding for the transmembrane domain of the ?-subunit of the T-cell receptor (TCR), a region that has been identified to be crucial for the assembly and function of the TCR.

Was shown to significantly inhibit T-cell-mediated inflammation upon subcutaneously administration in animal models. Has the potential of being used as an alternative therapy for immunosuppression.

Reference: Gerber D, Quintana FJ, Bloch I, Cohen IR, Shai Y. 2005. D-enantiomer peptide of the TCRalpha transmembrane domain inhibits T-cell activation in vitro and in vivo. FASEB J. 19(9):1190-2.

+
  • Prof. Yechiel Shai
265
Monoclonal antibodies specific to cholesterol/ceramide mixture Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid...

Monoclonal antibodies specific to cholesterol/ceramide mixture

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes.

Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes.

Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

+
  • Prof. Lia Addadi
120
Monoclonal antibodies raised against bFSH. Available clone: 1G12. Follicle-stimulating hormone (FSH) is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation and reproductive processes of the body.Reference: Somjen D1,...

Monoclonal antibodies raised against bFSH. Available clone: 1G12.
Follicle-stimulating hormone (FSH) is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation and reproductive processes of the body.
Reference: Somjen D1, Tordjman K, Kohen F, Baz M, Razon N, Ouaknine G, Stern N. 1997. Combined beta FSH and beta LH response to TRH in patients with clinically non-functioning pituitary adenomas. Clin Endocrinol (Oxf). 46(5):555-62.

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

Peptide Hormones:

§  120 – Monoclonal antibody to FSH

Description: Monoclonal antibodies raised against bFSH. Available clone: 1G12.

Follicle-stimulating hormone (FSH) is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation and reproductive processes of the body.

      Reference: Somjen D1, Tordjman K, Kohen F, Baz M, Razon N, Ouaknine G, Stern N. 1997. Combined beta FSH and beta LH response to TRH in patients with clinically non-functioning pituitary adenomas. Clin Endocrinol (Oxf). 46(5):555-62.


 

+
  • Dr. Fortune Kohen
179
179 - Allyl-mercapto-captopril (CPSSA - Captosal) Description: Conjugation between allicin (the biologically active molecule in garlic) and captopril, a known antihypertensive drug. Was shown to offer therapeutic benefits for the treatment of the metabolic syndrome, as demonstrated by various animal...

179 - Allyl-mercapto-captopril (CPSSA - Captosal)

Description: Conjugation between allicin (the biologically active molecule in garlic) and captopril, a known antihypertensive drug. Was shown to offer therapeutic benefits for the treatment of the metabolic syndrome, as demonstrated by various animal models. These include improvement of glucose tolerance, preventing weight gain, lowering blood pressure, reducing cardiac hypertrophy and potent antioxidant activities.

Reference: Miron T, Rabinkov A, Peleg E, Rosenthal T, Mirelman D, Wilcheck M. 2004. Allylmercaptocaptopril: a new antihypertensive drug. Am. J. Hypertens. 1:71-73.

+
  • Prof. David Mirelman
252
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Anti-idiotypic antibody raised against anti-progesterone-7- BSA.KLH conjugate (clone 2H4)....

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Anti-idiotypic antibody raised against anti-progesterone-7- BSA.KLH conjugate (clone 2H4). Available clones: 15F11 (betatypic), 2E11  (alphatypic).
Reference: Fort?ne Kohen, Josef de Boever, Geoff Barnard. 1996.  Noncompetitive immunoassay for small molecules. Immunoassay. Pages  405-421.

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Anti-idiotypic antibodies to anti-steroids:

§  252-253 - Anti-idiotypic antibodies against anti-progesterone   

      Description: Anti-idiotypic antibody raised against anti-progesterone-7-     BSA.KLH conjugate (clone 2H4). Available clones: 15F11 (betatypic), 2E11 (alphatypic).

            Reference: Fort?ne Kohen, Josef de Boever, Geoff Barnard. 1996. Noncompetitive immunoassay for small molecules. Immunoassay. Pages 405-421.

 
+
  • Dr. Fortune Kohen
101
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes: §  101 – Monoclonal antibody to LTC4 Description: Rat monoclonal antibodies raised...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

§  101 – Monoclonal antibody to LTC4

Description: Rat monoclonal antibodies raised against Leukotriene C4-KLH.

Available clone:  6E7 (IgG1).

Cysteinyl leukotrienes are potent lipid mediators in inflammation, inducing

smooth muscle contractions and increased capillary permeability.

 
+
  • Dr. Fortune Kohen
315
315 - TBBL (5-thiobutyl butyrolactone) Description: TBBL (5-thiobutyl butyrolactone) is a chromogenic lipo-lactone substrate for Serum paraoxonases (PONs), used for sera tests of PONs activity, based on their lactonase activity.  The primary enzymatic reaction produces an unstable intermediate that...

315 - TBBL (5-thiobutyl butyrolactone)

Description: TBBL (5-thiobutyl butyrolactone) is a chromogenic lipo-lactone substrate for Serum paraoxonases (PONs), used for sera tests of PONs activity, based on their lactonase activity.  The primary enzymatic reaction produces an unstable intermediate that rapidly collapses to release a fluorescent/chromogenic moiety.

Can be used with a variety of biological samples, for example, serum, cells or cell lysates and suitable for high-throughput screens.

Serum paraoxonase (PON1) is a high-density lipoprotein(HDL)-associated enzyme with antiatherogenic and detoxification properties that hydrolyzes a wide range of substrates and exhibits a wide range of physiologically important activities, including cholesterol efflux, drug metabolism and the detoxification of Ops (organophosphates).

Reference: Khersonsky O, Tawfik DS. 2006. Chromogenic and fluorogenic assays for the lactonase activity of serum paraoxonases. Chembiochem. 7(1):49-53.

+
  • Prof. Dan S. Tawfik
147
Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception. Monoclonal antibodies for peptide and steroid hormones Due to their high...

Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).
Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Peptide Hormones:

§  147-148 - Monoclonal antibody to hCG

Description: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).

Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

 
+
  • Dr. Fortune Kohen
274
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.   §  127, 274, 141 – Monoclonal...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  127, 274, 141 – Monoclonal antibodies to estradiol         

      Description: Monoclonal antibodies raised against oestradiol-6-     carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b),    8D9 (IgG2a).

Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.

            References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.

            S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304.

+
  • Dr. Fortune Kohen
130
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Veterinary drugs: §  130 - Anti-idiotypic antibody against anti-Sulfamethazine...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Veterinary drugs:

§  130 - Anti-idiotypic antibody against anti-Sulfamethazine

                              Description: Betetypic anti-idiotypic antibody raised against anti Sulfamethazine –KLH (clone 21C7). Available clone: 12E12.

Reference: Fortune Kohen , Batya Gayer , Yehudith Amir-Zaltsman &

Michael O'Keeffe. 2000. Generation of an anti-idiotypic antibody as a surrogateLigand for sulfamethazine in immunoassay procedures, food and agricultural. Immunology 12:3 193-201.

 
+
  • Dr. Fortune Kohen
182
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

Monoclonal antibodies to IgE

Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

+
  • Prof. Zelig Eshhar
257
257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin. Gliomedin, a glial ligand for neurofascin and NrCAM, is...

257 - Monoclonal antibody to Gliomedin

Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin.

Gliomedin, a glial ligand for neurofascin and NrCAM, is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment, aligned with the forming nodes of Ranvier. Gliomedin was shown to induce ion channel organization along the nerve axons, elicit formation of myelin and initiate node formation. Immuno-detection of Gliomedin may be used for diagnostics of neurological pathologies or as a marker for nodes of Ranvier in human and various animal model systems.

Reference: Eshed Y, Feinberg K, Poliak S, Sabanay H, Sarig-Nadir O, Spiegel I, Bermingham JR Jr, Peles E. 2005. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. Neuron. 47(2):215-29.

+
  • Prof. Elior Peles
115
  Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Veterinary drugs: § 115 - Monoclonal antibody to Sulfamethazine (SMZ)...

 

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Veterinary drugs:

§ 115 - Monoclonal antibody to Sulfamethazine (SMZ)

Description: Rat monoclonal antibodies raised against Sulfamethazine-BSA.

    Available clone: 21C7, IgG1.

Sulfamethazine is an antibacterial agents commonly given to food animals (swine, fishetc.) to prevent disease and maximize production.

Reference: Fortune Kohen , Batya Gayer , Yehudith Amir-Zaltsman &

Michael O'Keeffe. 2000. Generation of an anti-idiotypic antibody as a surrogateLigand for sulfamethazine in immunoassay procedures, food and agricultural. Immunology 12:3 193-201.

+
  • Dr. Fortune Kohen
155
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Isoflavones: §  155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin    Description: 7...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Isoflavones:

§  155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin

   Description: 7-(O)-carboxymethyl formononetin is an isoflavone derivative, active as a selective estrogen receptor modulator.

 

 

+
  • Dr. Fortune Kohen
276
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. §  275-276 – Monoclonal antibodies to...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

§  275-276 – Monoclonal antibodies to estrone-3-glucuronide

Description: Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3.

Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.

            References: Geoff Barnard, Fortune Kohen. 1998. Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Clin Chem 44:7 1520–1528.

Barnard G1, Kohen F, Mikola H, L?vgren T. 1989. Measurement of estrone-3-glucuronide in urine by rapid, homogeneous time-resolved fluoroimmunoassay. Clin Chem. 35(4):555-9.

 
+
  • Dr. Fortune Kohen

Pages