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Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against oestradiol-6- carboxymethyl oxime-BSA. Available clones:...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Monoclonal antibodies raised against oestradiol-6- carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b),  8D9 (IgG2a).
Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.
References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.
S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304. 

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  127, 274, 141 – Monoclonal antibodies to estradiol         

      Description: Monoclonal antibodies raised against oestradiol-6-     carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b),    8D9 (IgG2a).

Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.

            References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.

            S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304.


 

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  • Dr. Fortune Kohen
253
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Anti-idiotypic antibodies to anti-...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Anti-idiotypic antibodies to anti-steroids:

§  252-253 - Anti-idiotypic antibodies against anti-progesterone   

      Description: Anti-idiotypic antibody raised against anti-progesterone-7-     BSA.KLH conjugate (clone 2H4). Available clones: 15F11 (betatypic), 2E11 (alphatypic).

            Reference: Fort?ne Kohen, Josef de Boever, Geoff Barnard. 1996. Noncompetitive immunoassay for small molecules. Immunoassay. Pages 405-421.

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  • Dr. Fortune Kohen
103
103 - Bone marrow derived stroma cell line 14F1.1 Description: An endothelial-adipose cell line derived from a murine bone marrow stroma. Reference: Zipori D, Toledo J, von der Mark K. 1985. Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular...

103 - Bone marrow derived stroma cell line 14F1.1

Description: An endothelial-adipose cell line derived from a murine bone marrow stroma.

Reference: Zipori D, Toledo J, von der Mark K. 1985. Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition and interactions with normal and leukemic cells. Blood. Aug;66(2):447-55.

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  • Prof. Dov Zipori
320
320 - Monoclonal antibody G63 Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells. MAFA is a type II membrane glycoprotein, which was shown to inhibit the secretory response to the type 1 Fc?  receptor (Fc? RI) stimulus...

320 - Monoclonal antibody G63

Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells. MAFA is a type II membrane glycoprotein, which was shown to inhibit the secretory response to the type 1 Fc?  receptor (Fc? RI) stimulus. Binding of G63 antibody to MAFA was shown to enhance this inhibition by enhanced MAFA clustering.

Reference: Ortega Soto E, Pecht I. 1988. A monoclonal antibody that inhibits secretion from rat basophilic leukemia cells and binds to a novel membrane component. J Immunol. 141(12):4324-32.

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  • Prof. Israel Pecht
148
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Peptide Hormones: §  147-148 -...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Peptide Hormones:

§  147-148 - Monoclonal antibody to hCG

Description: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).

Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

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  • Dr. Fortune Kohen
185
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

Monoclonal antibodies to IgE

Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

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  • Prof. Zelig Eshhar
275
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat,...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3.
Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
References: Geoff Barnard, Fortune Kohen. 1998. Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Clin Chem 44:7 1520–1528.
Barnard G1, Kohen F, Mikola H, L?vgren T. 1989. Measurement of estrone-3-glucuronide in urine by rapid, homogeneous time-resolved fluoroimmunoassay. Clin Chem. 35(4):555-9.

 

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  275-276 – Monoclonal antibodies to estrone-3-glucuronide

Description: Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3.

Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.

            References: Geoff Barnard, Fortune Kohen. 1998. Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Clin Chem 44:7 1520–1528.

Barnard G1, Kohen F, Mikola H, L?vgren T. 1989. Measurement of estrone-3-glucuronide in urine by rapid, homogeneous time-resolved fluoroimmunoassay. Clin Chem. 35(4):555-9.

 

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  • Dr. Fortune Kohen
132
WISH-PC frozen tissue samples Description: Neuroendocrine xenograft model of human prostatic small cell carcinoma cancer. Provides a source to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic...

WISH-PC frozen tissue samples

Description: Neuroendocrine xenograft model of human prostatic small cell carcinoma cancer. Provides a source to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic strategies for prostatic small cell carcinoma.

WISH-PC2: Taken from a patient diagnosed with T3N1M1 prostatic adenocarcinoma with a Gleason score of 8 (3 + 5). Obtained during a palliative transuretheral resection of the prostate. Independent of Androgen and does not secretes prostate-specific antigen.

WISH-PC14: Taken from a channel transurethral resection of the prostate of a late recurrent primary tumor, Gleason score 9 (4 + 5), after definitive radiation therapy. Androgen dependent and secretes prostate-specific antigen.

WISH-PC23: Taken from prostatic adenocarcinoma harvested during palliative trans urethral resection of the prostate performed in a patient with local progression of adenocarcinoma of the prostate, Gleason score 6 (3 + 3).

Reference: Pinthus JH, Waks T, Schindler DG, Harmelin A, Said JW, Belldegrun A, Ramon J, Eshhar Z. 2000. WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma. Cancer Res. 60(23):6563-7.

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  • Prof. Zelig Eshhar
258
258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a...

258 - Monoclonal antibody to Ermin

Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis.

Reference: Brockschnieder D, Sabanay H, Riethmacher D, Peles E. 2006. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. J Neurosci. 26(3):757-62.

 

Tech # 1269

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  • Prof. Elior Peles
116
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Biotin: §  116, 142 – Monoclonal antibody to Biotin            Description: Monoclonal...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Biotin:

§  116, 142 – Monoclonal antibody to Biotin

           Description: Monoclonal antibodies raised against biotinylated BSA.

           Available clones: F1, F4.

Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). Functions as coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.

Reference: Bag?i H1, Kohen F, Kus?uoglu U, Bayer EA, Wilchek M. 1993. Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin. FEBS Lett. 322(1):47-50.

 

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  • Dr. Fortune Kohen
169
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Steroid Hormones: §  119, 169 –...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Steroid Hormones:

§  119, 169 – Monoclonal antibodies to Testosterone          

      Description: Rat monoclonal antibodies raised against testosterone 3-(0-   carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.

Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.

Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.

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  • Dr. Gad Lavie
236
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides...

236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis

Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both D- and L amino acids (diastereomers). These peptides have demonstrated potent anti-cancer and anti metastatic activities in several animal models including models for prostate and lung cancer. They were shown to successfully inhibit tumor growth when injected intratumorally or intraveneously. The 15-mer Histidine form shows reduced systemic toxicity.

References: Papo N, Braunstein A, Eshhar Z, Shai Y. 2004. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16):5779-86.

Makovitzki A1, Fink A, Shai Y. 2009. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res. 69(8):3458-63.

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  • Prof. Yechiel Shai
279
  • Prof. Joel L. Sussman
141
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.   §  127, 274, 141 – Monoclonal...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  127, 274, 141 – Monoclonal antibodies to estradiol         

      Description: Monoclonal antibodies raised against oestradiol-6-     carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b),    8D9 (IgG2a).

Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.

            References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.

            S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304.

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  • Dr. Fortune Kohen
176
176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the...

176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase

Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115).

ERK belongs to the family of mitogen-activated protein kinases (MAPKs) and is an important component in many intracellular signaling events. ERK is phosphorylated and activated by the upstream kinases, MEK1 and MEK2 on regulatory Threonin (Thr) and tyrosine (Tyr) residues, which are localized in the activation loop of ERK.

Reference: Yao Z, Dolginov Y, Hanoch T, Yung Y, Ridner G, Lando Z, Zharhary D, Seger R. 2000. Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases. FEBS Lett. 468(1):37-42.

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  • Prof. Rony Seger

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