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Technology Number: 

320

Principal Investigator

Prof.
Israel
Pecht

Department: 

Immunology
Summary 

320 - Monoclonal antibody G63

Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells. MAFA is a type II membrane glycoprotein, which was shown to inhibit the secretory response to the type 1 Fc?  receptor (Fc? RI) stimulus. Binding of G63 antibody to MAFA was shown to enhance this inhibition by enhanced MAFA clustering.

Reference: Ortega Soto E, Pecht I. 1988. A monoclonal antibody that inhibits secretion from rat basophilic leukemia cells and binds to a novel membrane component. J Immunol. 141(12):4324-32.

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