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Category
Technology Name
Briefcase
Scientist
1102
A new high-yield method for producing aryl alkenes. Catalytic carbon-carbon bond formation by C-H activation is a topic of much current interest. Significant progress has been made in recent years in the development of synthetically useful catalytic addition of arenes to alkenes to give the saturated...

A new high-yield method for producing aryl alkenes. Catalytic carbon-carbon bond formation by C-H activation is a topic of much current interest. Significant progress has been made in recent years in the development of synthetically useful catalytic addition of arenes to alkenes to give the saturated aryl alkenes. Catalytic oxidative coupling to give aryl alkenes, in which the double bond is preserved, is a highly desirable goal. Such a reaction, which does not require the utilization of a reactive substituent and does not produce waste, may have an advantage over other methods for the preparation of aromatic alkenes. While good catalytic activity was achieved with some alkenes, acrylates resulted in low activity. Furthermore, the use of peroxide oxidants and acetic acid solvent in these systems is problematic from the industrial point of view. The present invention consists of a novel oxidative coupling of arenes with alkenes to yield aryl alkenes, in the presence of ruthenium or osmium compounds as catalysts.

Applications


  • Preparation of various aryl alkenes, which are useful intermediates in the chemical, pharmaceutical and agrochemical industries

Advantages


  • There is no need for acid solvent or a peroxide
  • Much lower pressure of CO may be used compared to other methods

Technology's Essence


In the outlined technology it was discovered that aryl alkenes can be produced by reaction of arenes with alkenes in the presence of ruthenium or osmium compounds as catalysts. The reaction can be carried out in the presence of molecular oxygen (O2) as the oxidant. In the absence of O2 the alkene itself serves as the oxidant. For example, reaction of benzene with methyl acrylate and O2 produces methyl cinnamate and water. In the absence of O2 methyl cinnamate and methyl propionate are formed.

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  • Prof. David Milstein
1507
One-step synthesis of primary amines from alcohols and ammonia under mild conditions.Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual...

One-step synthesis of primary amines from alcohols and ammonia under mild conditions.
Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual growth of 3.5%.
Primary amines are most useful in the larger markets of ethanolamines and fatty amines.
Current synthetic methods require harsh reaction conditions, are non-specific and generate toxic waste. The outlined technology utilizes a novel catalyst to synthesize primary amines in a simple single-step fashion directly from alcohols and ammonia.

Applications


• Production of primary amines for numerous industries (agrochemicals, surfactants, personal care, water treatment, fine chemicals, plastics, dyes, pigments, food additives and pharmaceuticals)

Advantages


  • Mild reaction conditions
  • Single step synthesis
  • High yields
  • No solvent required
  • No toxic reagents or by-products
  • Ecologically and economically beneficial

Technology's Essence


Amines are a very important family of compounds used in multiple industries. The presented technology uses selective catalytic synthesis of primary amines from primary alcohols and ammonia. This simple, one-step, easily applicable reaction delivers primary amines in good yields, in addition to valuable environmental and economic advantages.

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  • Prof. David Milstein
1184
Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they...

Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they induce with high specificity and accuracy at parts-per-billion (ppb) levels.

Applications


Transducer which may be developed to suite: Medical diagnostics: point of care, real time diagnostics of chemical and biological substances. Environmental watch: monitoring air or water pollution, testing for food poisoning. Chemical warfare: detection of chemical agents and explosives. Industry: monitoring industrial processes at real time.

Technology's Essence


Researchers at the Weizmann Institute have developed a platform technology based on novel hybrid chemical-electronic detector MOCSER (MOlecular Controlled SEmiconductor Resistor). The technology is based on a new type of a Gallium Arsenide (GaAs) electronic device covered with a monolayer of sensing molecules. The detection is achieved by measuring the current changes created due to analyte binding. The researchers have succeeded in showing high sensitivity and accuracy of the device down to parts per billion (ppb) levels. They have also demonstrated the possibility for broad applications of this detector by tailoring different sensing molecules on it and measuring various substances.

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  • Prof. Ron Naaman
  • Prof. David Cahen

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