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1124
Label-free detection and monitoring of target molecules, which can be conducted using standard lab equipment. This new method of optical analysis is effective in monitoring the binding of chemically or physically adsorbed molecules, in liquid or gas phase, with measurements carried out continuously in...

Label-free detection and monitoring of target molecules, which can be conducted using standard lab equipment. This new method of optical analysis is effective in monitoring the binding of chemically or physically adsorbed molecules, in liquid or gas phase, with measurements carried out continuously in real-time.

SPR and LSPR technologies are broadly used in efficient real-time detection and quantification of biomolecules in research environments; however these technologies are too complicated, cumbersome and expensive for routine applications. This novel technology combines real-time, high sensitivity and accuracy of LSPR with low cost and ease of use of other optical assays, such as ELISA.

The invention comprises the LSPR transducer element of a gold-island film biosensor, which does not suffer shortcomings such as extreme temperature sensitivity. The gold island film is rapidly integrated into lab consumables via a novel fabrication method, which produces a robust system for high-throughput molecular diagnostics.

Applications


  • Point of care, real time diagnostics of chemical and biological substances.
  • Environmental watch: monitoring air or water pollution, testing for food poisoning.
  • Chemical warfare: detection of chemical agents and explosives.
  • Real-time monitoring of marine biofouling or industry corrosion processes.

Advantages


  • Simple operation, versatile and inexpensive method to imbed sensor in standard lab consumables.
  • High-throughput label-free detection with sensitivity comparable to that of SPR.
  • Uses cheap, disposable samples.
  • Can be combined with a variety of biosensing technologies.

Technology's Essence


The method involves evaporation of ultrathin (?10 nm) gold films onto inert transparent substrates (e.g., glass, plastic) leading to the formation of a layer of gold islands. Gold-island films provide unique optical properties. Such films show a localized surface plasmon (LSP) absorption peak much less sensitive to the refractive index of the surrounding medium. The LSP absorption band changes upon binding of various molecules to the surface. The binding process can be followed quantitatively by measuring the changes in the gold SP absorption. Selective sensing using the LSPR method can be achieved by applying a thin layer containing receptor molecules onto the gold island film, and measuring changes in the SP absorption upon binding of a specific analyte to the receptor layer

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  • Prof. Israel Rubinstein
1529
We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This...

We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This results only in a narrow efficient spectral band of conversion. Other techniques such as periodic quasi-phase matching result in improved efficiencies but still within a narrow predetermined band. Random quasi-phase matching results in improved bandwidth but in a significant reduction in efficiency. This new device enables ultra-broadband wavelength conversion while maintaining high efficiency.

Applications


  • Laser optics industry
  • Frequency convertor for broadband signals
  • Generation of ultrafast visible radiation
  • Pulse selection.

Advantages


  • 90% efficiency of conversion process.
  • Simple and compact
  • Insensitive to the deviations in alignment, no dependence of the angle incidence beam or of temperature
  • Frequency converter of both broadband signals and ultra-short pulses.

Technology's Essence


This device is based on a new method of adiabatic wavelength conversion. The device works whereby a strong narrow-band pump is introduced into the crystal along with a weaker pulse to be converted. This conversion is realized in a quasi-phase matched nonlinear crystal, where the period is tuned adiabatically from strong negative phase-mismatch to strong positive phase-mismatch (or vice versa). This results in the efficient transformation of the weaker pulse.

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  • Prof. Yaron Silberberg
1397
A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

Applications


Primary applications in research. Use as a detection tool in western blotting, immunoprecipitation and chromatin immunoprecipitation. Might be used for monitoring processes associated with modulations of ubiquitinated-H2B levels.

Technology's Essence


The invention involves the generation of antibodies specific to ubiquitinated-H2B which selectively recognize H2B when it is ubiquitinated but not H2B in its unmodified state, or ubiquitin unconjugated to H2B.

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  • Prof. Moshe Oren
1503
Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers. Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of...

Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers.

Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of the above can impact the freshness of produce from harvest to end-consumer. Researchers at the Weizmann Institute found that under certain stress conditions model plants produce Ureides, shown to have a protective role. Unexpectedly, this protection can also be achieved by the exogenous application to plants or plant parts post-harvest.

This innovative technique to preserve and prolong the shelf-life of fresh produce is clean, organic and cost-effective. In addition, engineered strains with altered Ureides metabolism can prove more resistant to stress related senescence.

Applications


  • Post-harvest protection of produce via
  • Exogenous application (spray on leaves, add to roots etc.).
  • Incorporation in packaging (e.g. embedded in plastic film).

Advantages


  • Treatment of both aging and light-deprivation in plants
  • Readily available and easily applied, does not require expertise to protect produce
  • Organic, clean, biodegradable materials.

Technology's Essence


Prof. Robert Fluhr and his team found that in wild-type plants conditions of extended darkness or increasing leaf age caused induction of transcripts related to purine catabolism, resulting in marked accumulation of Ureides. In contrast, Arabidopsis mutants of XDH, Atxdh1, accumulated the Ureides precursor (Xanthine) and showed premature senescence symptoms such as enhanced chlorophyll degradation, extensive cell death and upregulation of senescence-related transcripts.

The level of plant reactive oxygen species (ROS) and mortality can be attenuated by the addition of Ureides, suggesting that these metabolites can act as scavengers of ROS. The results highlighted that the regulation of Ureides levels by Atxdh1 has implications for optimal plant survival during nutrient remobilization, such as occurs during normal growth, dark stress and senescence.

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  • Prof. Robert Fluhr
1267
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains...

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. 
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. 
Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

M263, M264, M265

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  • Prof. Lia Addadi
1448
A method to produce amides in one step without any unwanted by-products, by coupling of alcohols with amines with the liberation of hydrogen gas, catalyzed by unique ruthenium complexes. Amides are widely used in the industry (e.g. nylon, Kevlar) and have widespread importance in biochemical and...

A method to produce amides in one step without any unwanted by-products, by coupling of alcohols with amines with the liberation of hydrogen gas, catalyzed by unique ruthenium complexes.

Amides are widely used in the industry (e.g. nylon, Kevlar) and have widespread importance in biochemical and chemical systems (e.g. proteins). Synthesis of amides is mostly based on activated acid derivatives or rearrangement reactions induced by an acid or base, which often produce toxic chemical waste and involve tedious procedures. Therefore, an efficient synthesis that avoids wasteful use of coupling reagents or corrosive acidic and basic media is highly desirable. The current technology allows for the clean production of amides from amines and alcohols.

Applications


  • Production of amides for various applications (plastic and rubber industry, paper industry, pharmaceutical intermediates, etc.)

  • Use of the liberated hydrogen (e.g. for the production of ammonia)


Advantages


  • Clean and selective procedure

  • Environment friendly reaction (no base or acid promoters are required, no carboxylic acid derivatives, such as acid chlorides, are needed)

  • Amides and molecular hydrogen are produced in high yields and high turnover numbers directly from alcohols in one step

  • The liberated hydrogen can be used for different applications

  • Formation of a variety of amides


Technology's Essence


Amide formation is a fundamental reaction in chemical synthesis. Amides are commonly formed from the reaction of a carboxylic acid derivative with an amine. Instead of using carboxylic acid derivative, in the present invention the amide motif is generated by direct acylation of amines with alcohols. This is possible through the use of a unique catalyst. This method enables the simple and elegant production of amide polymers and industrially important amides.

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  • Prof. David Milstein
1166
A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs.

A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs.

Applications


Monitoring hormone and drug additives in food providing animals for veterinary use and for the food industry.

Technology's Essence


Researchers at the Weizmann Institute of Science have developed a series of mAb against peptide and steroid hormones, isoflavones, and human and veterinary drugs. These antibodies are particularly valuable for monitoring hormone and drug additives in food providing animals. The mAb are available for diagnostics, research, and therapeutics.

The following mAb are available for licensing:

(Clones marked with * are available for diagnostic and therapeutic use only).

Peptide Hormones:
LH: 4F10
bFSH: 1G12*, 1H9, 1H7
FSH: 6H6
bHCG: 1D5
bHCG+: 1C7 3F11
HGH: 1C12*, 1C4*, 5E9, 4E12, 5C3, 1C5, 6G3, 5E6, 2C12

Steroid Hormones:
progesterone-11a-HS 1E11*
progesterone-7a-CET 2H4
Estrone-3-glucuronide 8A3
Testosterone-3-CMO 5A4
Testosterone-3-CMO 5F2*
Estradiol-6-CMO 8D9*

Anti-idiotypic antibodies to anti-steroids:
betatypic anti-anti-testosterone 5A4 8G9
betatypic anti-progesterone 2H4 15F11
betatypic anti-anti-estrone-3-glucuronide 8A3 7C1
alphatypic anti-progesterone 2H4 2E11
betatypic anti-anti-estrone-3-glucuronide 8A3 11C1

Drugs
Digoxin 10F10
RU-486* 8B6*
Buserelin 8B4
Medroxy-progesterone-acetate* 1F5*

Leukotrienes
LTC4* 6E7

Biotin
Biotin-BSA F1

Isoflavones
Daidzein 4E4
Daidzein/daidzin/genistin 2F11
Estrone-3-glucuronide 8A3
Genistein/biochanin A 10D8
Genistein/genistin/daidzin 6E8
Betatypic anti-anti-genistein 10D8

Veterinary drugs
Sulfamethazine (SMZ) 21C7
Betatypic anti-SMZ 12E12
4-chloro-androstenedione 14H2
Virginamycin 486
Spiramycin 110
Betatypic anti-anti-spiramycin 133

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  • Dr. Fortune Kohen
1507
One-step synthesis of primary amines from alcohols and ammonia under mild conditions.Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual...

One-step synthesis of primary amines from alcohols and ammonia under mild conditions.
Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual growth of 3.5%.
Primary amines are most useful in the larger markets of ethanolamines and fatty amines.
Current synthetic methods require harsh reaction conditions, are non-specific and generate toxic waste. The outlined technology utilizes a novel catalyst to synthesize primary amines in a simple single-step fashion directly from alcohols and ammonia.

Applications


• Production of primary amines for numerous industries (agrochemicals, surfactants, personal care, water treatment, fine chemicals, plastics, dyes, pigments, food additives and pharmaceuticals)

Advantages


  • Mild reaction conditions
  • Single step synthesis
  • High yields
  • No solvent required
  • No toxic reagents or by-products
  • Ecologically and economically beneficial

Technology's Essence


Amines are a very important family of compounds used in multiple industries. The presented technology uses selective catalytic synthesis of primary amines from primary alcohols and ammonia. This simple, one-step, easily applicable reaction delivers primary amines in good yields, in addition to valuable environmental and economic advantages.

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  • Prof. David Milstein
1357
A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants. The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving...

A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants.

The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving drainage and supply of high quality water have been developed to overcome this problem, the existing methods are extremely costly and time-consuming. In many instances, due to the increased need for extensive agriculture, neither improved irrigation efficiency nor the installation of drainage systems is applicable. Current attempts to enhance the salinity tolerance of crop plants are based on conventional breeding and selection of resistant variants. However, such breeding techniques typically require years to develop, are labor intensive and expensive.  The present invention relates to the transformation of salt inducible or salt-responsive genes into plants, thus turning them into having high salt tolerance.

Applications


  • Salt resistant plants can grow in soils containing a high salt concentration
  • Survival of salt shock
  • Modification of  plant recovery after exposure to salt stress

Advantages


  • The use of genes adapted specifically to very high salt concentrations, rather than genes from regular plants, makes the transgenic plants superior compared to other salt-tolerant plants
  • Transgenic plants can grow in seawater, thus saving precious drinking water

Technology's Essence


The unicellular green algae Dunaliella salina, a dominant organism in many saline environments, can adapt to practically the entire range of salinities. Dunaliella proteins function at high salinity, and this special feature of the proteins was utilized in order to confer salt-tolerance in plants. In the outlined invention plants were transformed with genes from Dunaliella, thus creating transgenic plants that have increased tolerance to salt as compared to corresponding non-transgenic plants.

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  • Prof. Uri Pick
185
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

Monoclonal antibodies to IgE

Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

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  • Prof. Zelig Eshhar
275
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat,...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3.
Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
References: Geoff Barnard, Fortune Kohen. 1998. Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Clin Chem 44:7 1520–1528.
Barnard G1, Kohen F, Mikola H, L?vgren T. 1989. Measurement of estrone-3-glucuronide in urine by rapid, homogeneous time-resolved fluoroimmunoassay. Clin Chem. 35(4):555-9.

 

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  275-276 – Monoclonal antibodies to estrone-3-glucuronide

Description: Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3.

Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.

            References: Geoff Barnard, Fortune Kohen. 1998. Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Clin Chem 44:7 1520–1528.

Barnard G1, Kohen F, Mikola H, L?vgren T. 1989. Measurement of estrone-3-glucuronide in urine by rapid, homogeneous time-resolved fluoroimmunoassay. Clin Chem. 35(4):555-9.

 

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  • Dr. Fortune Kohen
132
WISH-PC frozen tissue samples Description: Neuroendocrine xenograft model of human prostatic small cell carcinoma cancer. Provides a source to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic...

WISH-PC frozen tissue samples

Description: Neuroendocrine xenograft model of human prostatic small cell carcinoma cancer. Provides a source to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic strategies for prostatic small cell carcinoma.

WISH-PC2: Taken from a patient diagnosed with T3N1M1 prostatic adenocarcinoma with a Gleason score of 8 (3 + 5). Obtained during a palliative transuretheral resection of the prostate. Independent of Androgen and does not secretes prostate-specific antigen.

WISH-PC14: Taken from a channel transurethral resection of the prostate of a late recurrent primary tumor, Gleason score 9 (4 + 5), after definitive radiation therapy. Androgen dependent and secretes prostate-specific antigen.

WISH-PC23: Taken from prostatic adenocarcinoma harvested during palliative trans urethral resection of the prostate performed in a patient with local progression of adenocarcinoma of the prostate, Gleason score 6 (3 + 3).

Reference: Pinthus JH, Waks T, Schindler DG, Harmelin A, Said JW, Belldegrun A, Ramon J, Eshhar Z. 2000. WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma. Cancer Res. 60(23):6563-7.

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  • Prof. Zelig Eshhar
169
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Steroid Hormones: §  119, 169 –...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Steroid Hormones:

§  119, 169 – Monoclonal antibodies to Testosterone          

      Description: Rat monoclonal antibodies raised against testosterone 3-(0-   carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.

Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.

Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.

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  • Dr. Gad Lavie
258
258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a...

258 - Monoclonal antibody to Ermin

Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis.

Reference: Brockschnieder D, Sabanay H, Riethmacher D, Peles E. 2006. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. J Neurosci. 26(3):757-62.

 

Tech # 1269

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  • Prof. Elior Peles
116
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Biotin: §  116, 142 – Monoclonal antibody to Biotin            Description: Monoclonal...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Biotin:

§  116, 142 – Monoclonal antibody to Biotin

           Description: Monoclonal antibodies raised against biotinylated BSA.

           Available clones: F1, F4.

Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). Functions as coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.

Reference: Bag?i H1, Kohen F, Kus?uoglu U, Bayer EA, Wilchek M. 1993. Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin. FEBS Lett. 322(1):47-50.

 

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  • Dr. Fortune Kohen

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