You are here

Category
Technology Name
Briefcase
Scientist
1267
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains...

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. 
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. 
Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

M263, M264, M265

+
  • Prof. Lia Addadi
1499
Bladder cancer is a common malignancy; it is the 4th most common cancer in males and the 9th in females.  The presenting symptom is usually blood in the urine, and diagnosis is currently based on cystoscopy, which is invasive, costly, painful and time consuming.  To date, no biomarker has been...

Bladder cancer is a common malignancy; it is the 4th most common cancer in males and the 9th in females.  The presenting symptom is usually blood in the urine, and diagnosis is currently based on cystoscopy, which is invasive, costly, painful and time consuming.  To date, no biomarker has been identified in the urine that might be used for screening, staging, prognosis and monitoring treatment.  We now report that the amount of the 60 kDa heat shock protein (HSP60) in a subject’s urine is a biomarker for muscle invasion in patients with bladder cancer – stage T2 and higher.  Moreover, subjects with stage T1 disease can be stratified by their urine levels of HSP60 into a sub-group likely to progress into stage T2 or into a sub-group more likely to respond to conservative treatment with BCG, which does not require removal of the bladder.  The distinction between these two sub-groups of T1 bladder cancer can identify earlier subjects in need of cystectomy, while sparing others unnecessary major surgery.

Applications


  • Screening subjects with overt hematuria, or at risk of developing bladder cancer (such as heavy smokers)
  • tratifying bladder cancer subjects
  • Prognosis
  • Determining treatment program
  • Monitoring response to therapy.

Advantages


  • Non-invasive
  • Easy to apply
  • Relatively inexpensive
  • Prognositic.

Technology's Essence


Quantitative measurement of HSP60 levels in a subject’s urine by ELISA, radio-immunoassay or other simple assays.

+
  • Prof. Irun R. Cohen
1166
A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs.

A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs.

Applications


Monitoring hormone and drug additives in food providing animals for veterinary use and for the food industry.

Technology's Essence


Researchers at the Weizmann Institute of Science have developed a series of mAb against peptide and steroid hormones, isoflavones, and human and veterinary drugs. These antibodies are particularly valuable for monitoring hormone and drug additives in food providing animals. The mAb are available for diagnostics, research, and therapeutics.

The following mAb are available for licensing:

(Clones marked with * are available for diagnostic and therapeutic use only).

Peptide Hormones:
LH: 4F10
bFSH: 1G12*, 1H9, 1H7
FSH: 6H6
bHCG: 1D5
bHCG+: 1C7 3F11
HGH: 1C12*, 1C4*, 5E9, 4E12, 5C3, 1C5, 6G3, 5E6, 2C12

Steroid Hormones:
progesterone-11a-HS 1E11*
progesterone-7a-CET 2H4
Estrone-3-glucuronide 8A3
Testosterone-3-CMO 5A4
Testosterone-3-CMO 5F2*
Estradiol-6-CMO 8D9*

Anti-idiotypic antibodies to anti-steroids:
betatypic anti-anti-testosterone 5A4 8G9
betatypic anti-progesterone 2H4 15F11
betatypic anti-anti-estrone-3-glucuronide 8A3 7C1
alphatypic anti-progesterone 2H4 2E11
betatypic anti-anti-estrone-3-glucuronide 8A3 11C1

Drugs
Digoxin 10F10
RU-486* 8B6*
Buserelin 8B4
Medroxy-progesterone-acetate* 1F5*

Leukotrienes
LTC4* 6E7

Biotin
Biotin-BSA F1

Isoflavones
Daidzein 4E4
Daidzein/daidzin/genistin 2F11
Estrone-3-glucuronide 8A3
Genistein/biochanin A 10D8
Genistein/genistin/daidzin 6E8
Betatypic anti-anti-genistein 10D8

Veterinary drugs
Sulfamethazine (SMZ) 21C7
Betatypic anti-SMZ 12E12
4-chloro-androstenedione 14H2
Virginamycin 486
Spiramycin 110
Betatypic anti-anti-spiramycin 133

+
  • Dr. Fortune Kohen
1447
A cheap and effective solution for protecting RFID tags from power attacks. RFID tags are secure tags present in many applications (e.g. secure passports). They are poised to become the most far-reaching wireless technology since the cell phone, with worldwide revenues expected to reach $2.8 billion in...

A cheap and effective solution for protecting RFID tags from power attacks.

RFID tags are secure tags present in many applications (e.g. secure passports). They are poised to become the most far-reaching wireless technology since the cell phone, with worldwide revenues expected to reach $2.8 billion in 2009. RFID tags were believed to be immune to power analysis attacks since they have no direct connection to an external power supply. However, recent research has shown that they are vulnerable to such attacks, since it is possible to measure their power consumption without actually needing either tag or reader to be physically touched by the attacker. Furthermore, this attack may be carried out even if no data is being transmitted between the tag and the attacker, making the attack very hard to detect. The current invention overcomes these problems by a slight modification of the tag's electronic system, so that it will not be vulnerable to power analysis.

Applications


  • Improved security of RFID tags.

Advantages


  • Simple and cost-effective
  • The design involves changes only to the RF front-end of the tag, making it the quickest to roll-out


Technology's Essence


An RFID system consists of a high-powered reader communicating with a tag using a wireless medium. The reader generates a powerful electromagnetic field around itself and the tag responds to this field. In passive systems, placing a tag inside the reader's field also provides it with the power it needs to operate. According to the inventive concept, the power consumption of the computational element is detached from the power supply of the tag. Thus, the present invention can almost eliminate the power consumption information.

+
  • Prof. Adi Shamir
1357
A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants. The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving...

A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants.

The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving drainage and supply of high quality water have been developed to overcome this problem, the existing methods are extremely costly and time-consuming. In many instances, due to the increased need for extensive agriculture, neither improved irrigation efficiency nor the installation of drainage systems is applicable. Current attempts to enhance the salinity tolerance of crop plants are based on conventional breeding and selection of resistant variants. However, such breeding techniques typically require years to develop, are labor intensive and expensive.  The present invention relates to the transformation of salt inducible or salt-responsive genes into plants, thus turning them into having high salt tolerance.

Applications


  • Salt resistant plants can grow in soils containing a high salt concentration
  • Survival of salt shock
  • Modification of  plant recovery after exposure to salt stress

Advantages


  • The use of genes adapted specifically to very high salt concentrations, rather than genes from regular plants, makes the transgenic plants superior compared to other salt-tolerant plants
  • Transgenic plants can grow in seawater, thus saving precious drinking water

Technology's Essence


The unicellular green algae Dunaliella salina, a dominant organism in many saline environments, can adapt to practically the entire range of salinities. Dunaliella proteins function at high salinity, and this special feature of the proteins was utilized in order to confer salt-tolerance in plants. In the outlined invention plants were transformed with genes from Dunaliella, thus creating transgenic plants that have increased tolerance to salt as compared to corresponding non-transgenic plants.

+
  • Prof. Uri Pick
1506
A simple electrochemical method and apparatus for the continues production of CO (carbon monoxide) from CO2 as chemical storage for electrical energy and a basic material for further organic products. Constant progress is made in solar and wind alternative energy production. Unfortunately, these...

A simple electrochemical method and apparatus for the continues production of CO (carbon monoxide) from CO2 as chemical storage for electrical energy and a basic material for further organic products.

Constant progress is made in solar and wind alternative energy production. Unfortunately, these systems are weather and time-dependent. Additionally, most of the geographic areas best suited for harvesting these resources are remote from population centers. Therefore the need for a reliable method to store and transport renewable energy is clear.

CO can be easily converted into methanol, which is one of the major chemical raw materials and can by itself be used as fuel for diesel engines and the energy source for direct methanol fuel cells (DMFC).

At present no reliable method of CO2 to CO reduction is available. Either using low temperatures which leads to low thermodynamic efficiency (<60%), Requires precious metals for electrodes and results in toxic byproducts, or using high temperatures which Requires pure CO2 input and Produces a mixture of CO2 and CO.

The current technology describes an efficient, flexible, continues method for production of CO at high temperatures (900oC) without any byproducts or toxic materials.

Applications


  • Production of CO from CO2
  • Easy conversion into methanol

Advantages


·         No precious (Pt, Ag, Au, Pd) metals required

·         No hazardous chemicals involved, no pollution

·         Continuous operation is possible

·         One can use flue gas as a source

·         Capture of CO2 from air is possible

·         The system is very compact>20 kW/m3

·         Operation conditions are very flexible

·         The process fits existing infrastructure

·         CO can be easily converted into liquid fuel (CH3OH)


Technology's Essence


The outlined technology overcomes the basic problems of CO production by using molten Li2CO3 as the electrolyte, a Ti container (will not undergo corrosion), Ti cathode (does not catalyze decomposition of CO), and a graphite anode (no chemical reaction with Li2CO3). At 900°C and current density of 0.05-2 A/cm2, this unique system enables a thermodynamic efficiency close to 100%, continues production of CO – efficiently separating CO2 to CO and O2.

+
  • Prof. Igor Lubomirsky
1245

Applications


The novel DNA Aptamer is a promising candidate for therapeutic as well as diagnostic uses: Therapeutic: A novel therapy for Influenza Diagnostics: Detection of Influenza infection in vertebrates such as avian, swine and human

Technology's Essence


Scientists at the Weizmann Institute of Science describe a novel oligonucleotide, also known as an Aptamer, which has been designed to complement the receptor-binding region of the influenza haemagglutinin molecule. It was constructed by screening a DNA library and processing by the SELEX procedure. This DNA Aptamer comprises of a polynucleotide sequence that can bind to a polypeptide within the binding region of the influenza virus to the host cell. The proposed mode of action of this Aptamer is by blocking the binding of influenza virus to target cell receptors and consequently preventing the virus invasion into the host cells. Aptamer is capable of inhibiting the haemagglutinin capacity of the virus and the viral infectivity in vitro. Furthermore, it was shown in an animal model to inhibit viral infection by different influenza strains, as manifested by up to 99% reduction of virus burden in the lungs of treated mice.

+
  • Prof. Ruth Arnon
258
258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a...

258 - Monoclonal antibody to Ermin

Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis.

Reference: Brockschnieder D, Sabanay H, Riethmacher D, Peles E. 2006. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. J Neurosci. 26(3):757-62.

 

Tech # 1269

+
  • Prof. Elior Peles
116
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Biotin: §  116, 142 – Monoclonal antibody to Biotin            Description: Monoclonal...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Biotin:

§  116, 142 – Monoclonal antibody to Biotin

           Description: Monoclonal antibodies raised against biotinylated BSA.

           Available clones: F1, F4.

Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). Functions as coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.

Reference: Bag?i H1, Kohen F, Kus?uoglu U, Bayer EA, Wilchek M. 1993. Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin. FEBS Lett. 322(1):47-50.

 

+
  • Dr. Fortune Kohen
169
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Steroid Hormones: §  119, 169 –...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Steroid Hormones:

§  119, 169 – Monoclonal antibodies to Testosterone          

      Description: Rat monoclonal antibodies raised against testosterone 3-(0-   carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.

Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.

Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.

+
  • Dr. Gad Lavie
279
  • Prof. Joel L. Sussman
141
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.   §  127, 274, 141 – Monoclonal...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  127, 274, 141 – Monoclonal antibodies to estradiol         

      Description: Monoclonal antibodies raised against oestradiol-6-     carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b),    8D9 (IgG2a).

Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.

            References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.

            S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304.

+
  • Dr. Fortune Kohen
236
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides...

236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis

Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both D- and L amino acids (diastereomers). These peptides have demonstrated potent anti-cancer and anti metastatic activities in several animal models including models for prostate and lung cancer. They were shown to successfully inhibit tumor growth when injected intratumorally or intraveneously. The 15-mer Histidine form shows reduced systemic toxicity.

References: Papo N, Braunstein A, Eshhar Z, Shai Y. 2004. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16):5779-86.

Makovitzki A1, Fink A, Shai Y. 2009. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res. 69(8):3458-63.

+
  • Prof. Yechiel Shai
261
261 - Monoclonal antibody to GluR3B Description: Mouse monoclonal antibody (IgG2a), raised against a synthetic peptide of the Glutamate receptor (GluR3B), corresponding to amino acids 383-395 (NEYERFVPFSDQQISNDSSSSENR) of Leishmania donovani GluR3B. May be used for diagnosis as well as drug...

261 - Monoclonal antibody to GluR3B

Description: Mouse monoclonal antibody (IgG2a), raised against a synthetic peptide of the Glutamate receptor (GluR3B), corresponding to amino acids 383-395 (NEYERFVPFSDQQISNDSSSSENR) of Leishmania donovani GluR3B.

May be used for diagnosis as well as drug development for "autoimmune epilepsy”, a condition characterized by high levels of neuropathogenic human anti-GluR3B in serum and CSF.

+
  • Dr. Mia Levite
  • Prof. Vivian I. Teichberg
118
  Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Drugs: §  118 - Monoclonal antibody to Buserelin      Description: Rat...

 

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Drugs:

§  118 - Monoclonal antibody to Buserelin

     Description: Rat monoclonal antibodies raised against Buserelin.

     Available clone: 8B4, IgG1.

 
+
  • Dr. Fortune Kohen

Pages