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Technology Name
Briefcase
Scientist
1507
One-step synthesis of primary amines from alcohols and ammonia under mild conditions.Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual...

One-step synthesis of primary amines from alcohols and ammonia under mild conditions.
Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual growth of 3.5%.
Primary amines are most useful in the larger markets of ethanolamines and fatty amines.
Current synthetic methods require harsh reaction conditions, are non-specific and generate toxic waste. The outlined technology utilizes a novel catalyst to synthesize primary amines in a simple single-step fashion directly from alcohols and ammonia.

Applications


• Production of primary amines for numerous industries (agrochemicals, surfactants, personal care, water treatment, fine chemicals, plastics, dyes, pigments, food additives and pharmaceuticals)

Advantages


  • Mild reaction conditions
  • Single step synthesis
  • High yields
  • No solvent required
  • No toxic reagents or by-products
  • Ecologically and economically beneficial

Technology's Essence


Amines are a very important family of compounds used in multiple industries. The presented technology uses selective catalytic synthesis of primary amines from primary alcohols and ammonia. This simple, one-step, easily applicable reaction delivers primary amines in good yields, in addition to valuable environmental and economic advantages.

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  • Prof. David Milstein
1265
A Novel water treatment method capable of handling a wide spectrum of pollutants, both organic and metallic was developed by the group of Prof. Berkowitz and proven in large scale. The combination of ever-growing contamination from various sources (industry, agriculture and domestic uses), the toxicity...

A Novel water treatment method capable of handling a wide spectrum of pollutants, both organic and metallic was developed by the group of Prof. Berkowitz and proven in large scale.

The combination of ever-growing contamination from various sources (industry, agriculture and domestic uses), the toxicity of contaminating compounds, and their extreme persistence in the environment, define a complex challenge and serious threat. Feasible technological responses to deal with growing deterioration in water resource quality are difficult to develop, largely because of the wide variety of contaminants having different properties, the stringent environmental standards that must be met, and the inherent heterogeneity of natural aquatic systems. The quest for cost-effective, environmentally-acceptable methods that can target a wide spectrum of contaminants, in situ and ex situ, is urgent and critical today more than ever.

The approach of the technology presented here is to reduce their oxidation state, i.e., to transform them electrochemically. In most cases, complete transformation of contaminants from the oxidized-organic group produces environmentally innocuous compounds, while reduction of heavy metals renders them insoluble and immobile, and therefore much less harmful. These treatment methods can be applied both in situ and ex situ for decontamination of soils, sediments, water, wastewater and gaseous process streams.

Applications


•           Polluted water and wastewater treatment.

•           Soil decontamination.

•           Gaseous process stream treatment.


Advantages


•           Environmentally friendly output.

•           Cost effective.

•           Can be applied in situ as well as ex situ.


Technology's Essence


The treatment method presented here is based on nanosized zerovalent iron (nZVI) particles and cyanocobalamine (vitamin B12) on a diatomite matrix.  Cyanocobalamine is known to be an effective electron mediator, having strong synergistic effects with nZVI for reductive dehalogenation reactions. This composite material also improves the reducing capacity of nZVI by preventing agglomeration of iron nanoparticles, thus increasing their active surface area. The porous structure of the diatomite matrix allows

high hydraulic conductivity, which favors channeling of contaminated water to the reactive surface of the composite material resulting in faster rates of remediation. The composite material rapidly degrades or transforms completely a large spectrum of water contaminants, including halogenated solvents like TCE, PCE, and cis-DCE, pesticides like alachlor, atrazine and bromacyl, and common ions like nitrate, within minutes to hours.

 

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  • Prof. Brian Berkowitz
1397
A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

Applications


Primary applications in research. Use as a detection tool in western blotting, immunoprecipitation and chromatin immunoprecipitation. Might be used for monitoring processes associated with modulations of ubiquitinated-H2B levels.

Technology's Essence


The invention involves the generation of antibodies specific to ubiquitinated-H2B which selectively recognize H2B when it is ubiquitinated but not H2B in its unmodified state, or ubiquitin unconjugated to H2B.

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  • Prof. Moshe Oren
1461
Bidirectional Similarity offers a new approach to summarization of visual data (images and video) based on optimization of well defined similarity measure. Common visual summarization methods (mainly scaling and cropping) suffer from significant deficiencies related to image quality and loss of...

Bidirectional Similarity offers a new approach to summarization of visual data (images and video) based on optimization of well defined similarity measure.

Common visual summarization methods (mainly scaling and cropping) suffer from significant deficiencies related to image quality and loss of important data. Many attempts have been made to overcome these problems, however, success was very limited and neither has become commercially applicable.

Using an optimization problem approach and state-of-the-art algorithms, our method provides superior summarization of visual data as well as a measure to determine similarity, which together provides a basis for a wide range of applications in image and video processing.

Applications


The technology can be utilized in any application where an image size is changed or were similarity of images is important. Sample applications include:

  • Image processing software (as an added-on feature)

  • Resizing software

  • Creation of Thumbnails

  • Adjustment of images to different screen sizes (TV-cellular etc.)

  • Optimization of space-time patches in video processing

  • Image montages

  • Automatic image & video cropping

  • Images synthesis, photo reshuffling and many more


Advantages


While Bidirectional Similarity summarization will not replace existing technologies in all applications, it enjoys significant advantages that will offer better results in many of them. Among its advantages, the Bidirectional Similarity summarization:

  • Provides better resolution and in many cases reduces distortion compared to scaling
  • Reduces (or avoids) loss of important data compared to cropping
  • Allows importance-based summarization even when important information is widespread and hard to define
  • Uses quantitative objective similarity measure
  • Offers a generic tool for different image processing applications (synthesis, montage, reshuffling etc.)

Technology's Essence


Bidirectional Similarity Summarization is a patent-pending image and video processing method, which maximizes “completeness” and “coherence” between images and videos, using a measure for quantifying how “good” a visual summary is.

The algorithm uses and iterative process, gradually reducing the image size, while keeping all source patches in the target image, without introducing visual artifacts that are not in the input data. Using a Similarity Index, the algorithm identifies redundant information and compromise the “less important” data while generating the required target image or video.

The Similarity Index, which stands in the heart of the Bidirectional Similarity summarization algorithm, can be utilized by its own, as an objective function within other optimization processes, as well as in comparing the quality of visual summaries generated by different methods

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  • Prof. Michal Irani
1151
A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of...

A method to significantly shorten acquisition times of high-quality MRI images.

Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that, by contrast to one-dimensional spectroscpic methods, multidimensional NMR requires relatively long measurement times associated with hundreds or thousands of scans. This places certain kinds of rapidly-changing systems in Chemistry outside the scope of the technique. Long acquisition times also make this technique ill-suited for in vivo analyses and for clinical measurements in combination with magnetic resonance imaging (MRI). The current technology allows for the acquisition of multidimentional NMR scans using a single continuous scan, thereby shortening the time needed to acquire high-quality MRI images.

Applications


  • In vivo diagnostics

  • High-throughput proteomics/metabonomics

  • NMR of unstable chemical systems

  • Metabolic dynamics

  • High-resolution NMR in tabletop systems

  • Extensions to non-MR spectroscopies


Advantages


  • Can shorten the acquisition time of any multidimensional spectroscopy experiment by orders of magnitude
  • Compatible with the majority of multidimensional pulse sequences
  • Can be implemented using conventional NMR and MRI hardware

Technology's Essence


The outlined approach, called ultrafast multidimensional NMR, significantly expedites the analysis of the electromagnetic sounds produced, making it possible to acquire complete multidimensional NMR spectra within a fraction of a second. This technology “slices up” the molecular sample into numerous thin layers and then simultaneously performs all the measurements required on every one of these slices. The protocol then integrates these measurements according to their precise location, generating an image that amounts to a full multidimensional spectrum from the entire sample.

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  • Prof. Lucio Frydman
1518
Improved immunotherapy for breast cancer. Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of...

Improved immunotherapy for breast cancer.

Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of therapeutic mAbs and the evolution of patient resistance call for improvements. Furthermore, the response to the clinically approved monotherapy of Herceptin (a humanized mAb directed against ErbB-2), is relatively low (~15%) and short lived (median duration, 9 months). Therefore, there is a need to improve the therapeutic treatment against this receptor. The present technology enhances the therapeutic activity of anti-ErB-2 receptor antibodies, by combining two or more epitope-distinct antibodies.

Applications


  • Improved treatment of ErbB-2-overexpressing tumors (e.g. in breast and ovary cancers).


Advantages


  • May enhance patient response and delay acquisition of resistance.
  • Enhancement of therapeutic efficacy and synergy with chemotherapy.

Technology's Essence


Optimal selection of mAbs for cancer immunotherapy may improve its therapeutic potential. The outlined technology addresses an emerging strategy, which enhances the therapeutic activity of anti-receptor antibodies by combining two mAbs engaging distinct epitopes. It was demonstrated that pairs of anti-ErbB-2 mAbs better inhibit ErbB-2-overexpressing tumors than the respective individual mAbs, both in vitro and in vivo.

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  • Prof. Yosef Yarden
1267
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains...

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. 
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. 
Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

M263, M264, M265

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  • Prof. Lia Addadi
1481
In recent years, there has been a growing interest in the development of nanoscale magnetic and thermal characterization tools in order to address rapidly evolving fields, such as nanomagnetism, spintronics and energy-efficient computing. The requirements from these tools include high sensitivity and...

In recent years, there has been a growing interest in the development of nanoscale magnetic and thermal characterization tools in order to address rapidly evolving fields, such as nanomagnetism, spintronics and energy-efficient computing. The requirements from these tools include high sensitivity and high spatial resolution to enable local detection and accurate measurements of extremely low signals. For example, the energy dissipation mechanism in quantum systems is related to preservation of quantum information, which is of particular importance in the field of quantum computing. Available local magnetic imaging methods suffer from low sensitivity and in some cases, low spatial resolution. On the other hand, energy dissipation is not a readily measurable quantity on the nanometer scale and existing thermal imaging methods are not sensitive enough for studying quantum systems and are unsuitable for low temperature operation.

A novel sensor device comprising a nanoscale superconducting quantum interference device (SQUID) was developed by Prof. Zeldov at the Weizmann Institute of Science. The fabrication method enables the miniaturization of the sensor to an effective diameter of below 50 nm and its integration onto the apex of a very sharp tip that is ideally suited for scanning probe microscopy. The extremely small size of the SQUID-on-tip sensor and the ability to approach very close to the sample surface result in nano-metric spatial resolution and a very sensitivity.

Applications


·         Scanning probe microscopy for magnetic and thermal characterization

·         Inspection and probing equipment for quantum computing


Advantages


  • Simple fabrication process

  • High field sensitivity and bandwidth

  • Nanoscale sensors (down to 46 nm in diameter)

  • Tip-sample distance can be as close as a few nanometers


Technology's Essence


A SQUID is a very sensitive magnetometer used to measure extremely subtle magnetic fields, based on superconducting loops. The present invention is a novel sensor device, based on a nanoscale two-junction or multi-junction SQUIDs fabricated on the edge of a sharp tip in a three dimensional geometric configuration. In such a setup, the SQUID can approach the sample to a distance of few nanometers, as opposed to the conventional planar SQUIDs, which results in an extremely high sensitivity.

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  • Prof. Eli Zeldov
1184
Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they...

Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they induce with high specificity and accuracy at parts-per-billion (ppb) levels.

Applications


Transducer which may be developed to suite: Medical diagnostics: point of care, real time diagnostics of chemical and biological substances. Environmental watch: monitoring air or water pollution, testing for food poisoning. Chemical warfare: detection of chemical agents and explosives. Industry: monitoring industrial processes at real time.

Technology's Essence


Researchers at the Weizmann Institute have developed a platform technology based on novel hybrid chemical-electronic detector MOCSER (MOlecular Controlled SEmiconductor Resistor). The technology is based on a new type of a Gallium Arsenide (GaAs) electronic device covered with a monolayer of sensing molecules. The detection is achieved by measuring the current changes created due to analyte binding. The researchers have succeeded in showing high sensitivity and accuracy of the device down to parts per billion (ppb) levels. They have also demonstrated the possibility for broad applications of this detector by tailoring different sensing molecules on it and measuring various substances.

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  • Prof. Ron Naaman
  • Prof. David Cahen
1441
New protein as a target to treat B cell-related cancer.Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of...

New protein as a target to treat B cell-related cancer.
Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the overall goal of leukemia treatment is to bring about a remission. Therefore, identifying new proteins that may serve as a target for inducing cell death in the malignant cells is highly desirable. The present technology identifies a new regulator protein that is essential for the survival of CLL cells.

Applications


• Treatment of CLL, as well as other B cell-related cancers (e.g. gastric cancer and renal cell carcinoma), by blocking CD84 activity
• Diagnosis of CLL

Advantages


• Very specific to malignant B cells
• Diagnosis, and therefore treatment, can be made at early stages of the disease

 


Technology's Essence


B cells taken from CLL patients have a high level of the protein CD84. Stimulation of CD84 upregulates the survival of B-CLL. However, inhibition of CD84 activity with a blocking antibody downregulates the expression of another protein which controls B-CLL survival, thus inducing cell death. Therefore, the present invention reveals CD84 as a regulator of B-CLL survival

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  • Prof. Idit Shachar
1021
A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a...

A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a method for ray tracing, calculation of 3D space variant point spread, and generalized deconvolution.

Applications


Microscopy: The method was developed and applied for light microscopy, and is of critical importance for detection of weak fluorescently labeled molecules (like GFP fusion proteins) in live cells. It may be applicable also to confocal microscopy and other imaging methods like ultrasound, deep ocean sonar imaging, radioactive imaging, non-invasive deep tissue optical probing and photodynamic therapy. Gradient glasses: The determination of the three-dimensional refractive index of samples allows testing and optimization of techniques for production of gradient glasses. Recently continuous refractive index gradient glasses (GRIN, GRADIUM) were introduced, with applications in high quality optics, microlenses, aspherical lenses, plastic molded optics etc. Lenses built from such glasses can be aberration-corrected at a level, which required doublets and triplets using conventional glasses. Optimized performance of such optics requires ray tracing along curved path, as opposed to straight segments between surface borders of homogeneous glass lenses. Curved ray tracing is computation-intensive and dramatically slows down optimization of optical properties. Our algorithm for ray tracing in gradient refractive index eliminates this computational burden.

Technology's Essence


A computerized package to process three-dimensional images from live biological cells and tissues was developed in order to computationally correct specimen induced distortions that cannot be achieved by optical technique. The package includes: 1. Three-dimensional (3D) mapping of the refractive index of the specimen. 2. Fast method for ray tracing through gradient refractive index medium. 3. Three-dimensional space variant point spread function calculation. 4. Generalized three-dimensional deconvolution.

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  • Prof. Zvi Kam
1527
New peptides for improving the recruitment of stem cells for transplantation. Blood cancers (leukemia, lymphoma and myeloma) are very common: they accounted for nearly 9.5 percent of deaths in the US from cancer in 2009. Stem cell transplantation, which aims to restore the function of the marrow, is an...

New peptides for improving the recruitment of stem cells for transplantation.

Blood cancers (leukemia, lymphoma and myeloma) are very common: they accounted for nearly 9.5 percent of deaths in the US from cancer in 2009. Stem cell transplantation, which aims to restore the function of the marrow, is an important therapy for these malignancies. Successful blood and marrow transplant requires the infusion of a sufficient number of hematopoietic stem and progenitor cells (HSPC), which is done by recruitment of HSPC from the marrow into the blood (mobilization). Currently used clinical procedures to produce stem cell mobilization include administration of G-CSF or GM-CSF, either as single agents or in combination with chemotherapy. However, some autologous blood stem cell donors exhibit indifference to currently applied mobilization therapies. Hence, improved methods to mobilize peripheral blood HSPC are warranted. The present invention is directed to novel short peptides of beta-defensins for improving the mobilization of HSPC.

Applications


  • Rapid and efficient mobilization of HSPC for clinical transplantation
  • Inhibition of malignant cell proliferation and metastasis

Advantages


·         Non-toxic, derived from a physiological molecule of innate host immunity

·         Cheap and simple synthesis

·         Rapid, robust and preferential mobilization of immature HSPC

·         Enhancement of mobilizing efficiency of presently used substances (e.g. G-CSF)

·         Dual use of the derivatives


Technology's Essence


Beta-defensins belong to a family of antimicrobial peptides, a major component of the innate immune system. In a mouse model, two different linear beta-defensin-derived peptides provided a strong and rapid HSPC mobilization, alone and in combination with G-CSF, a cytokine that is the major agent inducing robust mobilization of HSPC. In addition, a cyclic peptide derivative effectively inhibited HSPC mobilization and proliferation, as well as human malignant cell motility in mice. These findings make beta-defensin-derived peptides as promising small molecule candidates for improving current clinical HSPC mobilization protocols, and their cyclic derivatives as promising candidates for reducing cancer cell development and metastasis in patients.

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  • Prof. Tsvee Lapidot
1357
A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants. The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving...

A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants.

The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving drainage and supply of high quality water have been developed to overcome this problem, the existing methods are extremely costly and time-consuming. In many instances, due to the increased need for extensive agriculture, neither improved irrigation efficiency nor the installation of drainage systems is applicable. Current attempts to enhance the salinity tolerance of crop plants are based on conventional breeding and selection of resistant variants. However, such breeding techniques typically require years to develop, are labor intensive and expensive.  The present invention relates to the transformation of salt inducible or salt-responsive genes into plants, thus turning them into having high salt tolerance.

Applications


  • Salt resistant plants can grow in soils containing a high salt concentration
  • Survival of salt shock
  • Modification of  plant recovery after exposure to salt stress

Advantages


  • The use of genes adapted specifically to very high salt concentrations, rather than genes from regular plants, makes the transgenic plants superior compared to other salt-tolerant plants
  • Transgenic plants can grow in seawater, thus saving precious drinking water

Technology's Essence


The unicellular green algae Dunaliella salina, a dominant organism in many saline environments, can adapt to practically the entire range of salinities. Dunaliella proteins function at high salinity, and this special feature of the proteins was utilized in order to confer salt-tolerance in plants. In the outlined invention plants were transformed with genes from Dunaliella, thus creating transgenic plants that have increased tolerance to salt as compared to corresponding non-transgenic plants.

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  • Prof. Uri Pick
1499
Bladder cancer is a common malignancy; it is the 4th most common cancer in males and the 9th in females.  The presenting symptom is usually blood in the urine, and diagnosis is currently based on cystoscopy, which is invasive, costly, painful and time consuming.  To date, no biomarker has been...

Bladder cancer is a common malignancy; it is the 4th most common cancer in males and the 9th in females.  The presenting symptom is usually blood in the urine, and diagnosis is currently based on cystoscopy, which is invasive, costly, painful and time consuming.  To date, no biomarker has been identified in the urine that might be used for screening, staging, prognosis and monitoring treatment.  We now report that the amount of the 60 kDa heat shock protein (HSP60) in a subject’s urine is a biomarker for muscle invasion in patients with bladder cancer – stage T2 and higher.  Moreover, subjects with stage T1 disease can be stratified by their urine levels of HSP60 into a sub-group likely to progress into stage T2 or into a sub-group more likely to respond to conservative treatment with BCG, which does not require removal of the bladder.  The distinction between these two sub-groups of T1 bladder cancer can identify earlier subjects in need of cystectomy, while sparing others unnecessary major surgery.

Applications


  • Screening subjects with overt hematuria, or at risk of developing bladder cancer (such as heavy smokers)
  • tratifying bladder cancer subjects
  • Prognosis
  • Determining treatment program
  • Monitoring response to therapy.

Advantages


  • Non-invasive
  • Easy to apply
  • Relatively inexpensive
  • Prognositic.

Technology's Essence


Quantitative measurement of HSP60 levels in a subject’s urine by ELISA, radio-immunoassay or other simple assays.

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  • Prof. Irun R. Cohen
1245

Applications


The novel DNA Aptamer is a promising candidate for therapeutic as well as diagnostic uses: Therapeutic: A novel therapy for Influenza Diagnostics: Detection of Influenza infection in vertebrates such as avian, swine and human

Technology's Essence


Scientists at the Weizmann Institute of Science describe a novel oligonucleotide, also known as an Aptamer, which has been designed to complement the receptor-binding region of the influenza haemagglutinin molecule. It was constructed by screening a DNA library and processing by the SELEX procedure. This DNA Aptamer comprises of a polynucleotide sequence that can bind to a polypeptide within the binding region of the influenza virus to the host cell. The proposed mode of action of this Aptamer is by blocking the binding of influenza virus to target cell receptors and consequently preventing the virus invasion into the host cells. Aptamer is capable of inhibiting the haemagglutinin capacity of the virus and the viral infectivity in vitro. Furthermore, it was shown in an animal model to inhibit viral infection by different influenza strains, as manifested by up to 99% reduction of virus burden in the lungs of treated mice.

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  • Prof. Ruth Arnon

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