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A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a...

A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a method for ray tracing, calculation of 3D space variant point spread, and generalized deconvolution.

Applications


Microscopy: The method was developed and applied for light microscopy, and is of critical importance for detection of weak fluorescently labeled molecules (like GFP fusion proteins) in live cells. It may be applicable also to confocal microscopy and other imaging methods like ultrasound, deep ocean sonar imaging, radioactive imaging, non-invasive deep tissue optical probing and photodynamic therapy. Gradient glasses: The determination of the three-dimensional refractive index of samples allows testing and optimization of techniques for production of gradient glasses. Recently continuous refractive index gradient glasses (GRIN, GRADIUM) were introduced, with applications in high quality optics, microlenses, aspherical lenses, plastic molded optics etc. Lenses built from such glasses can be aberration-corrected at a level, which required doublets and triplets using conventional glasses. Optimized performance of such optics requires ray tracing along curved path, as opposed to straight segments between surface borders of homogeneous glass lenses. Curved ray tracing is computation-intensive and dramatically slows down optimization of optical properties. Our algorithm for ray tracing in gradient refractive index eliminates this computational burden.

Technology's Essence


A computerized package to process three-dimensional images from live biological cells and tissues was developed in order to computationally correct specimen induced distortions that cannot be achieved by optical technique. The package includes: 1. Three-dimensional (3D) mapping of the refractive index of the specimen. 2. Fast method for ray tracing through gradient refractive index medium. 3. Three-dimensional space variant point spread function calculation. 4. Generalized three-dimensional deconvolution.

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  • Prof. Zvi Kam
1381

Applications


The new method for detecting irregularities has many applications which include:

  1. Detecting suspicious and/or salient behaviors in video
  2. Attention and saliency in images
  3. Detecting irregular tissue in medical images
  4. Automatic visual inspection for quality assurance (e.g., detecting defects in goods)
  5. Generating a video summary/synopsis
  6. Intelligent fast forward
  7. Non-visual data

    Technology's Essence


    Researchers at the Weizmann Institute have developed a new method for detecting irregularities based only on few regular examples, without any assumed models. In the new method the validity of data is determined as a process of constructing a puzzle: one tries to compose a new observed image region or a new video segment (''the query'') using chunks of data (''pieces of puzzle'') extracted from previous visual examples (''the database''). Regions in the observed data which can be composed using large contiguous chunks of data from the database are considered very likely, whereas regions in the observed data which cannot be composed from the database (or can be composed, but only using small fragmented pieces) are regarded as unlikely/suspicious. The problem is posed as an inference process in a probabilistic graphical model. The invention also includes an efficient algorithm for detecting irregularities. Moreover, the same method can also be used for detecting irregularities/anomalies within data without any prior examples, by learning the notion of regularity/irregularity directly from the query data itself.

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  • Prof. Michal Irani
1512
Materials with unique optical and magnetic properties for preventing counterfeiting. Product counterfeiting is a worldwide problem; the range of counterfeited goods touches almost all industries, from clothing to pharmaceuticals. It is estimated that counterfeiting is a $600 billion a year business,...

Materials with unique optical and magnetic properties for preventing counterfeiting.

Product counterfeiting is a worldwide problem; the range of counterfeited goods touches almost all industries, from clothing to pharmaceuticals. It is estimated that counterfeiting is a $600 billion a year business, and that counterfeit goods currently account for 5-7% of world trade. For this, companies need strategies that include various layers of security. Counterfeiters have learned to duplicate various types of security measures, so it is important to use a combination of overt and covert techniques simultaneously. The present technology consists of complexes and clusters  with a unique combination of optical and magnetic properties, that may be utilized for product authenticity.

Applications


  • Security 'markers' in documents or product authenticity, in the form of special printing inks or ink-jet applications


Advantages


  • Delayed emissions guarantees low noise level from exogenous fluorescent impurities

  • The clusters are emissive both in solution as well as in the solid state

  • Emissive complexes and clusters are circular polarized and therefore provide an additional layer of genuineness, as the true nature of the markers can only be identified using appropriate filters
  • The high magnetic properties of several of the compounds allows fast automated document screening


Technology's Essence


The outlined technology consists of a series of chiral organic ligands, their metal complexes, and several multi-nuclear clusters. Upon excitation, fluorescence emission can be selected to occur in the visible or the invisible near infrared regions of the spectrum. The spectrum is characterized by several well resolved emission maxima. The unique combination of optical and magnetic properties of these materials makes them promising candidates to serve as security 'markers'.

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  • Prof. Abraham Shanzer
1263
"Spin-optics", a new method for controlling electric current by manipulating electron spin-orbit interaction, can be used in semiconductors to achieve a wider spectrum of functionality similar to that achieved with polarized light. This method may be used for ultra-fast spin-based transistors.

"Spin-optics", a new method for controlling electric current by manipulating electron spin-orbit interaction, can be used in semiconductors to achieve a wider spectrum of functionality similar to that achieved with polarized light. This method may be used for ultra-fast spin-based transistors.

Applications


  • Ultra-fast spin-based field effect transistor (spin-FET) for communications, computing, and defense applications.
  • Nano- and micro-electronic semiconductor devices for polarizing, filtering, switching, guiding, storing, spin detecting and focusing the current carriers.
  • Devices for signal splitting and wide-angle sparging of electrons.

  • Advantages


    • Use of Nou-magnetic semiconductor materials
    • Creation of spin polarize current

    Technology's Essence


    Researchers at the Weizmann Institute of Science have discovered a novel method for controlling and manipulating the propagation of electrons in semiconductors with spin-orbit interaction by acting on the spin polarization of the electrons. It was found that when the spin-orbit coupling strength in the semiconductor is locally varying, electrons of different spin polarizations deflect by different angles at the region of the spin-orbit inhomogeneity. The spin-orbit coupling can be tuned locally and dynamically by applying bias voltage with gates. With suitable angle of incidence of electrons, one spin polarization either can pass through the region of inhomogeneity or totally reflected, in analogy to the total internal reflection phenomenon in optics. In fact, this new approach to spintronics is similar to manipulating polarized light in optical technologies. With this approach (termed "spin-optics") it is possible to manipulate the current carriers in semiconductors (electrons or holes) to achieve the whole spectrum of functionality used in optics of the polarized light, e.g., spin polarizing, spin filtering, switching, guiding as well as spin-based field effect transistor (spin-FET).

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    • Prof. Alexander Finkelstein
    1478
    Plants can regain enhanced color and aroma via increased production of aromatic amino acids. Researchers at the Weizmann institute of science discovered a key regulatory enzyme of a central metabolic pathway in bacteria and expressed it in plants, obtaining transgenic plants with increased levels of...

    Plants can regain enhanced color and aroma via increased production of aromatic amino acids. Researchers at the Weizmann institute of science discovered a key regulatory enzyme of a central metabolic pathway in bacteria and expressed it in plants, obtaining transgenic plants with increased levels of secondary metabolites including higher level of aromatic amino acids.

    Farmers and researches have implemented intense selective breeding in flowering plants as an attempt to improve features of decorative flowers, focusing on appearance and shelf life. Consequently, one of the most valuable qualities of the flower such as its scent and had been severely weakened. Traditional breeding is limited in its ability to supply the market demand for creating original or enhanced colors due to genetic requirements.

    The innovative method can improve scent and color of decorative flowering plants without interfering with other natural mechanisms of the plant.

    Applications


    • Improved esthetical value due to strong color and pleasant scent to ornamental flowers.
    • The color and scent of flowers has an additional eco-systematic role in the reproduction of fruits. Manipulating both color and odor may allow future optimized ability the repulse insects or attracts pollinators. 
    •  This method can be applied not only to enhance naturally existing color but also for the recently commercialized production of new colors of plants. For example flavonoid biosynthesis which was shown to be enhanced by this method was also found to be highly relevant in generating unique flowers colors

    Advantages


    • Enhanced fragrance and colors utilizing natural metabolic pathways of flowering plants.
    • No breeding and selection required to enhance flowers’ traits.
    • Endogenous integration between bacteria and plant that involves no interference with other natural mechanisms in the plants.

    Technology's Essence


    Researches at Prof. Gad Galili’s lab elicited a significant increase in the direct products of the shikimate pathway and in the aromatic amino acid Phenylalanine.

    A central regulator in the shikimate pathway is the first committed enzyme of the pathway; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS). The bacterial DAHPS is feedback inhibited by a separate amino acid. At the core of this technology is the dominant isoform that is the AroG gene which is under the regulation of Phenylalanine and responsible for 80% of the total DAHPS activity.

    By expressing a mutant bacterial AroG gene encoding a feedback insensitive DAHPS in transgenic Arabidopsis plants, researchers achieved increased levels of the shikimate direct metabolites, products and aromatic amino acids. Detailed analysis revealed that while no metabolite exhibited decreased levels in the transgenic plants, the levels of shikimate intermediate metabolites, phenylalanine, tryptophan, and a verity of secondary metabolites (such as auxin and hormones conjugates) were increased by the mutant bacterial gene.

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    • Prof. Gad Galili
    • Prof. Asaph Aharoni
    1121
    A method for aligning video images according to sequence. The problem of image alignment has been extensively studied, and successful approaches have been developed for solving this problem. However, these approaches turn out as problematic when there is insufficient overlap between the two images to...

    A method for aligning video images according to sequence. The problem of image alignment has been extensively studied, and successful approaches have been developed for solving this problem. However, these approaches turn out as problematic when there is insufficient overlap between the two images to allow extraction of common image properties, i.e., when there is no sufficient similarity (e.g., gray-level, frequencies, statistical) between the two images. Whereas two individual images cannot be aligned when there is no spatial overlap between them, this is not the case when dealing with image sequences. The outlined technology consists of fusion and alignment of discrete, non-overlapping moving images from different sources, by aligning spatio-temporal changes in each sequence rather than in each image.

    Applications


    • Multi-sensor image alignment for multi-sensor fusion
    • Alignment of images (sequences) obtained at significantly different zooms (can be useful in surveillance applications)
    • Generation of wide-screen movies from multiple non-overlapping narrow field-of-view movies (such as in IMAX movies) 
    • Alignment and integration of information across video sequences to exceed the physical visual limitations of any individual sensor (e.g., dynamic range, spectral range, spatial resolution, temporal resolution, etc). ~

    Advantages


    • Useful for spatially non-overlapping sequences
    • Useful in cases which are inherently difficult for standard image alignment techniques, such as when there is insufficient common spatial information across the two sequences

    Technology's Essence


    An image sequence contains much more information than any individual image frame does. In particular, temporal changes in a video sequence (e.g., due to camera motion) do not appear in any individual image frame, but are encoded between video frames. When these temporal changes are common to the two sequences, then these sequences can be aligned both in time and in space, even if there is no common spatial information whatsoever. The need for coherent visual appearance, which is a fundamental assumption in image alignment methods, is replaced in this invention with the requirement of coherent temporal behavior. This can be achieved by attaching the two video cameras closely to each other (so that their centers of projections are very close), and moving them jointly in space (e.g., such as when the two cameras are mounted on a moving platform or rig).

     

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    • Prof. Michal Irani
    1397
    A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

    A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

    Applications


    Primary applications in research. Use as a detection tool in western blotting, immunoprecipitation and chromatin immunoprecipitation. Might be used for monitoring processes associated with modulations of ubiquitinated-H2B levels.

    Technology's Essence


    The invention involves the generation of antibodies specific to ubiquitinated-H2B which selectively recognize H2B when it is ubiquitinated but not H2B in its unmodified state, or ubiquitin unconjugated to H2B.

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    • Prof. Moshe Oren
    1522
    A method for enhancing the spatial and or temporal resolution (if applicable) of an input signal such as images and videos.   Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have...

    A method for enhancing the spatial and or temporal resolution (if applicable) of an input signal such as images and videos.

     

    Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution). This method applies digital processing to reconstruct more satisfactory high resolution signals.

     

    Previous methods for Super-Resolution (SR) require multiple images of the same scene, or else an external database of examples. This method provides the ability to perform SR from a single image (or a single visual source). The algorithm exploits the inherent local data redundancy within visual signals (redundancy both within the same scale, and across different scales).

     

    Examples of the methods' capabilities can be found here: http://www.wisdom.weizmann.ac.il/~vision/SingleImageSR.html

     

    Applications


    • Enhancing the spatial resolution of images

    • Enhancing the spatial and or temporal resolution of video sequences

    • Enhancing the spatial and or temporal resolution (if applicable) of other signals (e.g., MRI, fMRI, ultrasound, possibly also audio, etc.)

     


    Advantages


    • No need for multiple low resolution sources or the use of an external database of examples.

    • Superior results are produced due to exploitation of inherent information in the source signal.


    Technology's Essence


    The framework combines the power of classical multi image super resolution and example based super resolution. This combined framework can be applied to obtain super resolution from as little as a single low-resolution signal, without any additional external information. The approach is based on an observation that patches in a single natural signal tend to redundantly recur many times inside the signal, both within the same scale, as well as across different scales.

    Recurrence of patches within the same scale (at subpixel misalignments) forms the basis for applying the 'classical super resolution' constraints to information from a single signal. Recurrence of patches across different (coarser) scales implicitly provides examples of low-resolution / high-resolution pairs of patches, thus giving rise to 'example-based super-resolution' from a single signal (but without any external database or any prior examples).

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    • Prof. Michal Irani
    1266
    Fast cross-sectioning using multiphoton microscope.  The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercial systems,...

    Fast cross-sectioning using multiphoton microscope.  The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercial systems, due to the scanning process. The field of confocal microscopy relies on the idea of point-by-point illumination of a sample and use mechanical scanning in order to collect an image. Multiphoton microscopes offer a different mechanism for optical sectioning and the need for rejecting out-of-focus scattering is practically eliminated. However, the process is efficient only when the peak intensity of the illuminating light is high. Thus there is a growing need to facilitate the multiphoton microscopy imaging of a sample by providing a novel illumination configuration and method of its operation.

    Depth-resolved microscopy has been, for decades, practically synonymous with laser-scanning microscopy. The technique of the present invention provides for full-frame depth-resolved microscopy (or material processing), using an extremely simple setup as well as standard components, aiming at eliminating mechanical scanning across the sample thus making the image acquisition much faster.

     

    Applications


    • Optical system for use in a multi-photon microscope.
    • Material processing, e.g. simultaneous depth-resolved modification of a transparent substrate by femtosecond radiation.

    Advantages


    • The present invention provides for fast imaging/processing of a sample without scanning.
    • The temporal profile of the pulse remains unchanged as it propagates through the sample.
    • Single-shot depth resolved microscopy is able to capture extremely rapid dynamics, up to the nanosecond regime.
    • The setup enables full-frame video-rate fluorescence lifetime imaging, simply by gating the CCD intensifier.
    • Enables utilization of structure illumination microscopy.
    • Can be used with practically any multiphoton process.

    Technology's Essence


    The present invention provides the ability for illuminating a region of a sample with dimensions many orders of magnitude larger than a diffraction-limited spot of the imaging lens arrangement used in the microscope. Using this method, full-frame depth-resolved microscopy can be achieved using an extremely simple setup and standard components. the proposed microscope utilizes a pulse manipulator arrangement including a temporal pulse manipulator configured to define a surface, which extends perpendicular to the optical axis of a microscope in the front focal plane of an imaging lens arrangement, and which is patterned to affect trajectories of light components of the input short pulse impinging onto different points of this surface to direct these light components along different optical paths.

    This novel invention is not limited to imaging techniques in general and to microscopy in particular and can also be used for material processing.

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    • Prof. Yaron Silberberg
    1482
    Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor. In the present disclosure we show that doping of MoS2 and WS2 nanotubes/nanoparticles can be accomplished by doping with either Re (n-type) or Nb (p-type) foreign atoms...

    Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor. In the present disclosure we show that doping of MoS2 and WS2 nanotubes/nanoparticles can be accomplished by doping with either Re (n-type) or Nb (p-type) foreign atoms. These nanoparticles combine both superior mechanical properties and high electrical conductivity.

    The main market for these kinds of nanoparticles is in thin films that combine superior mechanical and electrical properties. For example, as part of touch screensin addition, polymer nanocomposites containing such nanoparticles can be used among other things in electromagnetic shielding and conductive films for packaging and high performance adhesives. These nanoparticles are expected to reveal interesting catalytic applications, for example to obtain sulfur free gasoline. They can be used in third generation photovoltaic cells, etc.

    Applications


    • Catalytic processes for energy storage and sulfur free gasoline.
    • Polymer nanocomposites for packaging
    • Electromagnetic shielding.
    • Conductive glues/adhesives with superior performance.
    • Energy storage.

    Advantages


    The combination of superior mechanical properties and high electrical conductivity offers new kinds of applications in catalysis; energy storage; high performance nanocomposites and in macroelectronics.

     

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    • Prof. Tenne Reshef
    1151
    A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of...

    A method to significantly shorten acquisition times of high-quality MRI images.

    Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that, by contrast to one-dimensional spectroscpic methods, multidimensional NMR requires relatively long measurement times associated with hundreds or thousands of scans. This places certain kinds of rapidly-changing systems in Chemistry outside the scope of the technique. Long acquisition times also make this technique ill-suited for in vivo analyses and for clinical measurements in combination with magnetic resonance imaging (MRI). The current technology allows for the acquisition of multidimentional NMR scans using a single continuous scan, thereby shortening the time needed to acquire high-quality MRI images.

    Applications


    • In vivo diagnostics

    • High-throughput proteomics/metabonomics

    • NMR of unstable chemical systems

    • Metabolic dynamics

    • High-resolution NMR in tabletop systems

    • Extensions to non-MR spectroscopies


    Advantages


    • Can shorten the acquisition time of any multidimensional spectroscopy experiment by orders of magnitude
    • Compatible with the majority of multidimensional pulse sequences
    • Can be implemented using conventional NMR and MRI hardware

    Technology's Essence


    The outlined approach, called ultrafast multidimensional NMR, significantly expedites the analysis of the electromagnetic sounds produced, making it possible to acquire complete multidimensional NMR spectra within a fraction of a second. This technology “slices up” the molecular sample into numerous thin layers and then simultaneously performs all the measurements required on every one of these slices. The protocol then integrates these measurements according to their precise location, generating an image that amounts to a full multidimensional spectrum from the entire sample.

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    • Prof. Lucio Frydman
    1529
    We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This...

    We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This results only in a narrow efficient spectral band of conversion. Other techniques such as periodic quasi-phase matching result in improved efficiencies but still within a narrow predetermined band. Random quasi-phase matching results in improved bandwidth but in a significant reduction in efficiency. This new device enables ultra-broadband wavelength conversion while maintaining high efficiency.

    Applications


    • Laser optics industry
    • Frequency convertor for broadband signals
    • Generation of ultrafast visible radiation
    • Pulse selection.

    Advantages


    • 90% efficiency of conversion process.
    • Simple and compact
    • Insensitive to the deviations in alignment, no dependence of the angle incidence beam or of temperature
    • Frequency converter of both broadband signals and ultra-short pulses.

    Technology's Essence


    This device is based on a new method of adiabatic wavelength conversion. The device works whereby a strong narrow-band pump is introduced into the crystal along with a weaker pulse to be converted. This conversion is realized in a quasi-phase matched nonlinear crystal, where the period is tuned adiabatically from strong negative phase-mismatch to strong positive phase-mismatch (or vice versa). This results in the efficient transformation of the weaker pulse.

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    • Prof. Yaron Silberberg
    1270
    Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

    Monoclonal antibodies to IgE

    Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

    Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

    Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

    Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

     

    M182, M185, M186

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    • Prof. Zelig Eshhar
    1441
    New protein as a target to treat B cell-related cancer.Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of...

    New protein as a target to treat B cell-related cancer.
    Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the overall goal of leukemia treatment is to bring about a remission. Therefore, identifying new proteins that may serve as a target for inducing cell death in the malignant cells is highly desirable. The present technology identifies a new regulator protein that is essential for the survival of CLL cells.

    Applications


    • Treatment of CLL, as well as other B cell-related cancers (e.g. gastric cancer and renal cell carcinoma), by blocking CD84 activity
    • Diagnosis of CLL

    Advantages


    • Very specific to malignant B cells
    • Diagnosis, and therefore treatment, can be made at early stages of the disease

     


    Technology's Essence


    B cells taken from CLL patients have a high level of the protein CD84. Stimulation of CD84 upregulates the survival of B-CLL. However, inhibition of CD84 activity with a blocking antibody downregulates the expression of another protein which controls B-CLL survival, thus inducing cell death. Therefore, the present invention reveals CD84 as a regulator of B-CLL survival

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    • Prof. Idit Shachar
    1503
    Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers. Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of...

    Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers.

    Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of the above can impact the freshness of produce from harvest to end-consumer. Researchers at the Weizmann Institute found that under certain stress conditions model plants produce Ureides, shown to have a protective role. Unexpectedly, this protection can also be achieved by the exogenous application to plants or plant parts post-harvest.

    This innovative technique to preserve and prolong the shelf-life of fresh produce is clean, organic and cost-effective. In addition, engineered strains with altered Ureides metabolism can prove more resistant to stress related senescence.

    Applications


    • Post-harvest protection of produce via
    • Exogenous application (spray on leaves, add to roots etc.).
    • Incorporation in packaging (e.g. embedded in plastic film).

    Advantages


    • Treatment of both aging and light-deprivation in plants
    • Readily available and easily applied, does not require expertise to protect produce
    • Organic, clean, biodegradable materials.

    Technology's Essence


    Prof. Robert Fluhr and his team found that in wild-type plants conditions of extended darkness or increasing leaf age caused induction of transcripts related to purine catabolism, resulting in marked accumulation of Ureides. In contrast, Arabidopsis mutants of XDH, Atxdh1, accumulated the Ureides precursor (Xanthine) and showed premature senescence symptoms such as enhanced chlorophyll degradation, extensive cell death and upregulation of senescence-related transcripts.

    The level of plant reactive oxygen species (ROS) and mortality can be attenuated by the addition of Ureides, suggesting that these metabolites can act as scavengers of ROS. The results highlighted that the regulation of Ureides levels by Atxdh1 has implications for optimal plant survival during nutrient remobilization, such as occurs during normal growth, dark stress and senescence.

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    • Prof. Robert Fluhr

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