You are here

Category
Technology Name
Briefcase
Scientist
1478
Plants can regain enhanced color and aroma via increased production of aromatic amino acids. Researchers at the Weizmann institute of science discovered a key regulatory enzyme of a central metabolic pathway in bacteria and expressed it in plants, obtaining transgenic plants with increased levels of...

Plants can regain enhanced color and aroma via increased production of aromatic amino acids. Researchers at the Weizmann institute of science discovered a key regulatory enzyme of a central metabolic pathway in bacteria and expressed it in plants, obtaining transgenic plants with increased levels of secondary metabolites including higher level of aromatic amino acids.

Farmers and researches have implemented intense selective breeding in flowering plants as an attempt to improve features of decorative flowers, focusing on appearance and shelf life. Consequently, one of the most valuable qualities of the flower such as its scent and had been severely weakened. Traditional breeding is limited in its ability to supply the market demand for creating original or enhanced colors due to genetic requirements.

The innovative method can improve scent and color of decorative flowering plants without interfering with other natural mechanisms of the plant.

Applications


  • Improved esthetical value due to strong color and pleasant scent to ornamental flowers.
  • The color and scent of flowers has an additional eco-systematic role in the reproduction of fruits. Manipulating both color and odor may allow future optimized ability the repulse insects or attracts pollinators. 
  •  This method can be applied not only to enhance naturally existing color but also for the recently commercialized production of new colors of plants. For example flavonoid biosynthesis which was shown to be enhanced by this method was also found to be highly relevant in generating unique flowers colors

Advantages


  • Enhanced fragrance and colors utilizing natural metabolic pathways of flowering plants.
  • No breeding and selection required to enhance flowers’ traits.
  • Endogenous integration between bacteria and plant that involves no interference with other natural mechanisms in the plants.

Technology's Essence


Researches at Prof. Gad Galili’s lab elicited a significant increase in the direct products of the shikimate pathway and in the aromatic amino acid Phenylalanine.

A central regulator in the shikimate pathway is the first committed enzyme of the pathway; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS). The bacterial DAHPS is feedback inhibited by a separate amino acid. At the core of this technology is the dominant isoform that is the AroG gene which is under the regulation of Phenylalanine and responsible for 80% of the total DAHPS activity.

By expressing a mutant bacterial AroG gene encoding a feedback insensitive DAHPS in transgenic Arabidopsis plants, researchers achieved increased levels of the shikimate direct metabolites, products and aromatic amino acids. Detailed analysis revealed that while no metabolite exhibited decreased levels in the transgenic plants, the levels of shikimate intermediate metabolites, phenylalanine, tryptophan, and a verity of secondary metabolites (such as auxin and hormones conjugates) were increased by the mutant bacterial gene.

+
  • Prof. Gad Galili
  • Prof. Asaph Aharoni
1265
A Novel water treatment method capable of handling a wide spectrum of pollutants, both organic and metallic was developed by the group of Prof. Berkowitz and proven in large scale. The combination of ever-growing contamination from various sources (industry, agriculture and domestic uses), the toxicity...

A Novel water treatment method capable of handling a wide spectrum of pollutants, both organic and metallic was developed by the group of Prof. Berkowitz and proven in large scale.

The combination of ever-growing contamination from various sources (industry, agriculture and domestic uses), the toxicity of contaminating compounds, and their extreme persistence in the environment, define a complex challenge and serious threat. Feasible technological responses to deal with growing deterioration in water resource quality are difficult to develop, largely because of the wide variety of contaminants having different properties, the stringent environmental standards that must be met, and the inherent heterogeneity of natural aquatic systems. The quest for cost-effective, environmentally-acceptable methods that can target a wide spectrum of contaminants, in situ and ex situ, is urgent and critical today more than ever.

The approach of the technology presented here is to reduce their oxidation state, i.e., to transform them electrochemically. In most cases, complete transformation of contaminants from the oxidized-organic group produces environmentally innocuous compounds, while reduction of heavy metals renders them insoluble and immobile, and therefore much less harmful. These treatment methods can be applied both in situ and ex situ for decontamination of soils, sediments, water, wastewater and gaseous process streams.

Applications


•           Polluted water and wastewater treatment.

•           Soil decontamination.

•           Gaseous process stream treatment.


Advantages


•           Environmentally friendly output.

•           Cost effective.

•           Can be applied in situ as well as ex situ.


Technology's Essence


The treatment method presented here is based on nanosized zerovalent iron (nZVI) particles and cyanocobalamine (vitamin B12) on a diatomite matrix.  Cyanocobalamine is known to be an effective electron mediator, having strong synergistic effects with nZVI for reductive dehalogenation reactions. This composite material also improves the reducing capacity of nZVI by preventing agglomeration of iron nanoparticles, thus increasing their active surface area. The porous structure of the diatomite matrix allows

high hydraulic conductivity, which favors channeling of contaminated water to the reactive surface of the composite material resulting in faster rates of remediation. The composite material rapidly degrades or transforms completely a large spectrum of water contaminants, including halogenated solvents like TCE, PCE, and cis-DCE, pesticides like alachlor, atrazine and bromacyl, and common ions like nitrate, within minutes to hours.

 

+
  • Prof. Brian Berkowitz
1522
A method for enhancing the spatial and or temporal resolution (if applicable) of an input signal such as images and videos.   Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have...

A method for enhancing the spatial and or temporal resolution (if applicable) of an input signal such as images and videos.

 

Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution). This method applies digital processing to reconstruct more satisfactory high resolution signals.

 

Previous methods for Super-Resolution (SR) require multiple images of the same scene, or else an external database of examples. This method provides the ability to perform SR from a single image (or a single visual source). The algorithm exploits the inherent local data redundancy within visual signals (redundancy both within the same scale, and across different scales).

 

Examples of the methods' capabilities can be found here: http://www.wisdom.weizmann.ac.il/~vision/SingleImageSR.html

 

Applications


  • Enhancing the spatial resolution of images

  • Enhancing the spatial and or temporal resolution of video sequences

  • Enhancing the spatial and or temporal resolution (if applicable) of other signals (e.g., MRI, fMRI, ultrasound, possibly also audio, etc.)

 


Advantages


  • No need for multiple low resolution sources or the use of an external database of examples.

  • Superior results are produced due to exploitation of inherent information in the source signal.


Technology's Essence


The framework combines the power of classical multi image super resolution and example based super resolution. This combined framework can be applied to obtain super resolution from as little as a single low-resolution signal, without any additional external information. The approach is based on an observation that patches in a single natural signal tend to redundantly recur many times inside the signal, both within the same scale, as well as across different scales.

Recurrence of patches within the same scale (at subpixel misalignments) forms the basis for applying the 'classical super resolution' constraints to information from a single signal. Recurrence of patches across different (coarser) scales implicitly provides examples of low-resolution / high-resolution pairs of patches, thus giving rise to 'example-based super-resolution' from a single signal (but without any external database or any prior examples).

+
  • Prof. Michal Irani
1397
A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

Applications


Primary applications in research. Use as a detection tool in western blotting, immunoprecipitation and chromatin immunoprecipitation. Might be used for monitoring processes associated with modulations of ubiquitinated-H2B levels.

Technology's Essence


The invention involves the generation of antibodies specific to ubiquitinated-H2B which selectively recognize H2B when it is ubiquitinated but not H2B in its unmodified state, or ubiquitin unconjugated to H2B.

+
  • Prof. Moshe Oren
1151
A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of...

A method to significantly shorten acquisition times of high-quality MRI images.

Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that, by contrast to one-dimensional spectroscpic methods, multidimensional NMR requires relatively long measurement times associated with hundreds or thousands of scans. This places certain kinds of rapidly-changing systems in Chemistry outside the scope of the technique. Long acquisition times also make this technique ill-suited for in vivo analyses and for clinical measurements in combination with magnetic resonance imaging (MRI). The current technology allows for the acquisition of multidimentional NMR scans using a single continuous scan, thereby shortening the time needed to acquire high-quality MRI images.

Applications


  • In vivo diagnostics

  • High-throughput proteomics/metabonomics

  • NMR of unstable chemical systems

  • Metabolic dynamics

  • High-resolution NMR in tabletop systems

  • Extensions to non-MR spectroscopies


Advantages


  • Can shorten the acquisition time of any multidimensional spectroscopy experiment by orders of magnitude
  • Compatible with the majority of multidimensional pulse sequences
  • Can be implemented using conventional NMR and MRI hardware

Technology's Essence


The outlined approach, called ultrafast multidimensional NMR, significantly expedites the analysis of the electromagnetic sounds produced, making it possible to acquire complete multidimensional NMR spectra within a fraction of a second. This technology “slices up” the molecular sample into numerous thin layers and then simultaneously performs all the measurements required on every one of these slices. The protocol then integrates these measurements according to their precise location, generating an image that amounts to a full multidimensional spectrum from the entire sample.

+
  • Prof. Lucio Frydman
1482
Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor. In the present disclosure we show that doping of MoS2 and WS2 nanotubes/nanoparticles can be accomplished by doping with either Re (n-type) or Nb (p-type) foreign atoms...

Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor. In the present disclosure we show that doping of MoS2 and WS2 nanotubes/nanoparticles can be accomplished by doping with either Re (n-type) or Nb (p-type) foreign atoms. These nanoparticles combine both superior mechanical properties and high electrical conductivity.

The main market for these kinds of nanoparticles is in thin films that combine superior mechanical and electrical properties. For example, as part of touch screensin addition, polymer nanocomposites containing such nanoparticles can be used among other things in electromagnetic shielding and conductive films for packaging and high performance adhesives. These nanoparticles are expected to reveal interesting catalytic applications, for example to obtain sulfur free gasoline. They can be used in third generation photovoltaic cells, etc.

Applications


  • Catalytic processes for energy storage and sulfur free gasoline.
  • Polymer nanocomposites for packaging
  • Electromagnetic shielding.
  • Conductive glues/adhesives with superior performance.
  • Energy storage.

Advantages


The combination of superior mechanical properties and high electrical conductivity offers new kinds of applications in catalysis; energy storage; high performance nanocomposites and in macroelectronics.

 

+
  • Prof. Reshef Tenne
1529
We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This...

We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This results only in a narrow efficient spectral band of conversion. Other techniques such as periodic quasi-phase matching result in improved efficiencies but still within a narrow predetermined band. Random quasi-phase matching results in improved bandwidth but in a significant reduction in efficiency. This new device enables ultra-broadband wavelength conversion while maintaining high efficiency.

Applications


  • Laser optics industry
  • Frequency convertor for broadband signals
  • Generation of ultrafast visible radiation
  • Pulse selection.

Advantages


  • 90% efficiency of conversion process.
  • Simple and compact
  • Insensitive to the deviations in alignment, no dependence of the angle incidence beam or of temperature
  • Frequency converter of both broadband signals and ultra-short pulses.

Technology's Essence


This device is based on a new method of adiabatic wavelength conversion. The device works whereby a strong narrow-band pump is introduced into the crystal along with a weaker pulse to be converted. This conversion is realized in a quasi-phase matched nonlinear crystal, where the period is tuned adiabatically from strong negative phase-mismatch to strong positive phase-mismatch (or vice versa). This results in the efficient transformation of the weaker pulse.

+
  • Prof. Yaron Silberberg
1447
A cheap and effective solution for protecting RFID tags from power attacks. RFID tags are secure tags present in many applications (e.g. secure passports). They are poised to become the most far-reaching wireless technology since the cell phone, with worldwide revenues expected to reach $2.8 billion in...

A cheap and effective solution for protecting RFID tags from power attacks.

RFID tags are secure tags present in many applications (e.g. secure passports). They are poised to become the most far-reaching wireless technology since the cell phone, with worldwide revenues expected to reach $2.8 billion in 2009. RFID tags were believed to be immune to power analysis attacks since they have no direct connection to an external power supply. However, recent research has shown that they are vulnerable to such attacks, since it is possible to measure their power consumption without actually needing either tag or reader to be physically touched by the attacker. Furthermore, this attack may be carried out even if no data is being transmitted between the tag and the attacker, making the attack very hard to detect. The current invention overcomes these problems by a slight modification of the tag's electronic system, so that it will not be vulnerable to power analysis.

Applications


  • Improved security of RFID tags.

Advantages


  • Simple and cost-effective
  • The design involves changes only to the RF front-end of the tag, making it the quickest to roll-out


Technology's Essence


An RFID system consists of a high-powered reader communicating with a tag using a wireless medium. The reader generates a powerful electromagnetic field around itself and the tag responds to this field. In passive systems, placing a tag inside the reader's field also provides it with the power it needs to operate. According to the inventive concept, the power consumption of the computational element is detached from the power supply of the tag. Thus, the present invention can almost eliminate the power consumption information.

+
  • Prof. Adi Shamir
1267
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains...

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. 
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. 
Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

M263, M264, M265

+
  • Prof. Lia Addadi
1184
Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they...

Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they induce with high specificity and accuracy at parts-per-billion (ppb) levels.

Applications


Transducer which may be developed to suite: Medical diagnostics: point of care, real time diagnostics of chemical and biological substances. Environmental watch: monitoring air or water pollution, testing for food poisoning. Chemical warfare: detection of chemical agents and explosives. Industry: monitoring industrial processes at real time.

Technology's Essence


Researchers at the Weizmann Institute have developed a platform technology based on novel hybrid chemical-electronic detector MOCSER (MOlecular Controlled SEmiconductor Resistor). The technology is based on a new type of a Gallium Arsenide (GaAs) electronic device covered with a monolayer of sensing molecules. The detection is achieved by measuring the current changes created due to analyte binding. The researchers have succeeded in showing high sensitivity and accuracy of the device down to parts per billion (ppb) levels. They have also demonstrated the possibility for broad applications of this detector by tailoring different sensing molecules on it and measuring various substances.

+
  • Prof. Ron Naaman
  • Prof. David Cahen
1503
Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers. Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of...

Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers.

Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of the above can impact the freshness of produce from harvest to end-consumer. Researchers at the Weizmann Institute found that under certain stress conditions model plants produce Ureides, shown to have a protective role. Unexpectedly, this protection can also be achieved by the exogenous application to plants or plant parts post-harvest.

This innovative technique to preserve and prolong the shelf-life of fresh produce is clean, organic and cost-effective. In addition, engineered strains with altered Ureides metabolism can prove more resistant to stress related senescence.

Applications


  • Post-harvest protection of produce via
  • Exogenous application (spray on leaves, add to roots etc.).
  • Incorporation in packaging (e.g. embedded in plastic film).

Advantages


  • Treatment of both aging and light-deprivation in plants
  • Readily available and easily applied, does not require expertise to protect produce
  • Organic, clean, biodegradable materials.

Technology's Essence


Prof. Robert Fluhr and his team found that in wild-type plants conditions of extended darkness or increasing leaf age caused induction of transcripts related to purine catabolism, resulting in marked accumulation of Ureides. In contrast, Arabidopsis mutants of XDH, Atxdh1, accumulated the Ureides precursor (Xanthine) and showed premature senescence symptoms such as enhanced chlorophyll degradation, extensive cell death and upregulation of senescence-related transcripts.

The level of plant reactive oxygen species (ROS) and mortality can be attenuated by the addition of Ureides, suggesting that these metabolites can act as scavengers of ROS. The results highlighted that the regulation of Ureides levels by Atxdh1 has implications for optimal plant survival during nutrient remobilization, such as occurs during normal growth, dark stress and senescence.

+
  • Prof. Robert Fluhr
1021
A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a...

A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a method for ray tracing, calculation of 3D space variant point spread, and generalized deconvolution.

Applications


Microscopy: The method was developed and applied for light microscopy, and is of critical importance for detection of weak fluorescently labeled molecules (like GFP fusion proteins) in live cells. It may be applicable also to confocal microscopy and other imaging methods like ultrasound, deep ocean sonar imaging, radioactive imaging, non-invasive deep tissue optical probing and photodynamic therapy. Gradient glasses: The determination of the three-dimensional refractive index of samples allows testing and optimization of techniques for production of gradient glasses. Recently continuous refractive index gradient glasses (GRIN, GRADIUM) were introduced, with applications in high quality optics, microlenses, aspherical lenses, plastic molded optics etc. Lenses built from such glasses can be aberration-corrected at a level, which required doublets and triplets using conventional glasses. Optimized performance of such optics requires ray tracing along curved path, as opposed to straight segments between surface borders of homogeneous glass lenses. Curved ray tracing is computation-intensive and dramatically slows down optimization of optical properties. Our algorithm for ray tracing in gradient refractive index eliminates this computational burden.

Technology's Essence


A computerized package to process three-dimensional images from live biological cells and tissues was developed in order to computationally correct specimen induced distortions that cannot be achieved by optical technique. The package includes: 1. Three-dimensional (3D) mapping of the refractive index of the specimen. 2. Fast method for ray tracing through gradient refractive index medium. 3. Three-dimensional space variant point spread function calculation. 4. Generalized three-dimensional deconvolution.

+
  • Prof. Zvi Kam
1450
An MRI-based Non-invasive real-time depiction of Blood-Brain Barrier (BBB) abnormalities that enables a wide range of diagnostic, therapeutic and drug development applications.The BBB is a capillary barrier that protects the brain from fluctuations in blood chemistry and passage of certain particles...

An MRI-based Non-invasive real-time depiction of Blood-Brain Barrier (BBB) abnormalities that enables a wide range of diagnostic, therapeutic and drug development applications.
The BBB is a capillary barrier that protects the brain from fluctuations in blood chemistry and passage of certain particles between bloodstream and the brain. Selective delivery of compounds across the BBB by means of temporary/local BBB disruption is an emerging field. Therefore, means to monitor the BBB function non-invasively and in real-time are essential.Using existing MRI systems and state-of-the-art analytical tools, the methodology enables dynamic depiction of BBB physiological behavior, providing means to monitor changes in BBB permeability as wells as characterization of CNS pathologies. 

Applications


  • Assessment of CNS disorders – Diagnosis, Staging etc.

  • Monitoring the development of CNS disorders & response to treatment

  • Monitoring the effects of compounds or technologies on the BBB

  • Determine BBB function under certain physiological conditions  

  • Drug development:
    •  Modification of molecules to improve passage through the BBB.
    • Apply for the development of compounds/devices that affect BBB functioning.


Advantages


  • Non-invasive, real-time, 3D depiction of BBB functioning

  • Sensitivity to slight BBB abnormalities, undetected by conventional MRI

  • Acquired in parallel to conventional MRI enabling high resolution anatomical depiction

  • Can be acquired on available conventional clinical/pre-clinical MR systems using conventional data acquisition software


Technology's Essence


A methodology for analyzing the blood-brain barrier’s behavior, based on a detectable standard dose of MRI contrast agent. The methodology uses plurality of MRI images acquired from a subject’s brain over a predetermined time period, in order to asses BBB function in a uniquely sensitive manner. The system offers a combination of a data acquisition protocol and an offline software package, operating as an “add-on” to existing MRI systems. The system compares series of MRI constructed intensity maps, using different metrics to sensitively detect dissimilarities. The output is BBB functioning maps, depicting regions of BBB abnormalities.

+
  • Prof. Talila Volk
  • Dr. David Israeli
1357
A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants. The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving...

A method to introduce salt responsive genes from halo tolerant organisms was used to generate salt resistant transgenic plants.

The progressive salinization of agricultural soils poses a major limitation for the growth and productivity of crop plants. Although engineering technologies involving drainage and supply of high quality water have been developed to overcome this problem, the existing methods are extremely costly and time-consuming. In many instances, due to the increased need for extensive agriculture, neither improved irrigation efficiency nor the installation of drainage systems is applicable. Current attempts to enhance the salinity tolerance of crop plants are based on conventional breeding and selection of resistant variants. However, such breeding techniques typically require years to develop, are labor intensive and expensive.  The present invention relates to the transformation of salt inducible or salt-responsive genes into plants, thus turning them into having high salt tolerance.

Applications


  • Salt resistant plants can grow in soils containing a high salt concentration
  • Survival of salt shock
  • Modification of  plant recovery after exposure to salt stress

Advantages


  • The use of genes adapted specifically to very high salt concentrations, rather than genes from regular plants, makes the transgenic plants superior compared to other salt-tolerant plants
  • Transgenic plants can grow in seawater, thus saving precious drinking water

Technology's Essence


The unicellular green algae Dunaliella salina, a dominant organism in many saline environments, can adapt to practically the entire range of salinities. Dunaliella proteins function at high salinity, and this special feature of the proteins was utilized in order to confer salt-tolerance in plants. In the outlined invention plants were transformed with genes from Dunaliella, thus creating transgenic plants that have increased tolerance to salt as compared to corresponding non-transgenic plants.

+
  • Prof. Uri Pick
1245

Applications


The novel DNA Aptamer is a promising candidate for therapeutic as well as diagnostic uses: Therapeutic: A novel therapy for Influenza Diagnostics: Detection of Influenza infection in vertebrates such as avian, swine and human

Technology's Essence


Scientists at the Weizmann Institute of Science describe a novel oligonucleotide, also known as an Aptamer, which has been designed to complement the receptor-binding region of the influenza haemagglutinin molecule. It was constructed by screening a DNA library and processing by the SELEX procedure. This DNA Aptamer comprises of a polynucleotide sequence that can bind to a polypeptide within the binding region of the influenza virus to the host cell. The proposed mode of action of this Aptamer is by blocking the binding of influenza virus to target cell receptors and consequently preventing the virus invasion into the host cells. Aptamer is capable of inhibiting the haemagglutinin capacity of the virus and the viral infectivity in vitro. Furthermore, it was shown in an animal model to inhibit viral infection by different influenza strains, as manifested by up to 99% reduction of virus burden in the lungs of treated mice.

+
  • Prof. Ruth Arnon

Pages