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1571
A novel social behavior monitoring system automatically tracks the precise location of each animal at excellent temporal resolution. This innovative technology provides simultaneous identification of complex social and individual behaviors via an integration of RFID and video surveillance. There is a...

A novel social behavior monitoring system automatically tracks the precise location of each animal at excellent temporal resolution. This innovative technology provides simultaneous identification of complex social and individual behaviors via an integration of RFID and video surveillance.

There is a rapidly growing interest in detecting the molecular substrates of social behavior. This interest is driven by the vast implications of such understanding in both research and the pharmaceutical industry, since some prevalent pathological conditions are mainly characterized by a behavioral deficit or abnormality.

It is extremely challenging to quantify social behavior in a reliable manner. Existing methods struggle to find a balance between objectively quantifying behavior on one hand while enabling a natural, stress-free behavioral estimation on the other hand. Currently, researchers work in a strictly controlled and constrained environment that is estranged and stressful to the animals. The outcome is a highly contaminated measurement of natural behavior. This difficultly becomes increasingly complex when more than one animal is involved as often applied in social behavioral studies.

Applications


  • Rigorous characterization of social organizational deficiencies and evaluation of their severity in animal and human models (for example in autism).
  • An optimized system for estimating the efficacy of clinical treatments.

Advantages


  • Long-term tracking of unlimited number of simultaneously studied animals.
  • Machine based, hence objective and automated quantification of behavior.
  • Excellent spatiotemporal resolution in semi natural environment
  • Flexible- the number, size and distribution of the RFID antennas can be adjusted with different enclosure dimensions.
  • Can be applied from Individual behavioral profile or pairs interactions up to collective social organization of groups.
  • Systematic analysis and classification of basic locomotion up to more complex social

Technology's Essence


Researchers at the Weizmann institute developed a method for tightly controlled monitoring of social behavior in a semi-natural environment. They used integrated and synchronized chip reporting and continuous video postage to precisely locate each individual animal. Using this automated monitoring which provides an exceptional temporal resolution they achieved correct identification of numerous basic individual behaviors as well as complex social behaviors. Such complex behavioral profiles set the basis for subsequent analysis which reveals the formation of a social hierarchy.

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  • Dr. Tali Kimchi
1616
Existing treatments against cancer are non-sufficiently selective. Immunotherapy based treatment offers highly selective and efficient solution to this problem. A promising approach in Immunotherapy is adoptive cell therapy (ACT). In ACT, therapeutic lymphocytes are administrated to patients in order...

Existing treatments against cancer are non-sufficiently selective. Immunotherapy based treatment offers highly selective and efficient solution to this problem.
A promising approach in Immunotherapy is adoptive cell therapy (ACT). In ACT, therapeutic lymphocytes are administrated to patients in order to treat a disease. In this process antibody-type cells are generated ex vivo, and then infused to the patient. By this technology the cells can be redirected against specific tumors via genetic engineering, using chimeric receptors.
Currently ACT is logistically and economically challenging since it is limited by the used of the patients’ own cells. Another key concern is safety, due to the danger that the allogeneic cells will be rejected by the patient, or will attack the patient.
In cancer, use of tumor specific, chimeric receptor redirected allogeneic T cells can transform ACT into a standardized, off-the shelf therapy. Overall this method proposes a safe and effective adoptive therapy using allogeneic cells while avoiding the use of bone marrow transplantation (BMT).

Applications


  • Cancer immunotherapy

Advantages


  • Off the shelf, standard treatment
  • Safe
  • Effective
  • No bone marrow transplantation (BMT) is required

Technology's Essence


A novel approach for adoptive immunotherapy using fully MHC-mismatch allogeneic T cells. These cells are redirected with tumor specific non-MHC-restricted antibody-based chimeric antigen receptor (T-bodies) in the absence of Graft-versus-host disease (GVHD). In order to create a standardize treatment, the redirection of T cells can be done through an antibody-based chimeric antigen receptor (CAR), thus creating ‘universal effector T cells’. This is based on a combination of of MHC-mismatched allogeneic T-cells with an MHC unrestricted chimeric antigen receptor. These cells would recognize their target independently of MHC restriction, therefore applied as an ‘off-the shelf’ immunotherapy. Regarding the second challenge of avoiding GVHD, by using a controlled lymphodepletion the researchers were able to create therapeutic window during which the allo-T-body cells could destroy the tumor before being themselves rejected.

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  • Prof. Zelig Eshhar
1664
Neuroinflammation is well established as a key secondary injury mechanism following CNS trauma, such as traumatic brain/spinal injury or ischemic stroke, and it has been long considered to contribute to the damage sustained and fatal outcomes following brain injury. Early inflammatory events enhance...

Neuroinflammation is well established as a key secondary injury mechanism following CNS trauma, such as traumatic brain/spinal injury or ischemic stroke, and it has been long considered to contribute to the damage sustained and fatal outcomes following brain injury.
Early inflammatory events enhance brain damage, yet they provide the framework for later inflammatory events that enhance tissue remodeling and are crucial for tissue recovery.
A major unmet need in the field is a targeted treatment that would down regulate the damaging events of inflammation, while maintaining reparative functions. 
Altering between CNS microglia pro and anti-inflammatory activation states is at the core of injury-induced neuroinflammation and presents an opportunity to specifically tilt the balance towards anti-inflammatory and repair processes.
The present discovery elucidates the mechanisms that lead to injury-induced microglia over-activation and proposes IFN-? as a therapeutic strategy to induce microglia resolving state and relive inflammation. 

Applications


Anti-inflammatory treatment following CNS injury

Advantages


  • Targeted therapy – avoids general immuno-suppressive side effects
  • Based on a well understood molecular mechanism
  • May allow relatively large therapeutic window – according to proof-of-concept  preliminary experiments

Technology's Essence


Resident microglia are the major specialized innate immune cells of the central nervous system (CNS). During the process of wound healing or pathogen removal, there is an induction of the microglia active pro-inflammatiry phenotype (M1), leading to a transient inflammatory response, which is resolved via local conversion to the M2 anti-inflammatory phenotype.  Following acute injury, microglia fail to acquire an inflammation-resolving phenotype (M2-like phenotype) in a timely manner, often resulting in self-perpetuating local inflammation and tissue destruction beyond the primary insult.
Prof. Schwartz and her team uncovered the mechanisms that lead to injury-based inhibition of the M1 to M2 phenotype switch.  They showed that the capacity to undergo pro- to anti-inflammatory (M1-to-M2) phenotype switch is controlled by the transcription factor Interferon regulatory factor-7 (IRF7).  Their results demonstrate that restoring Irf7 expression by IFN-? (a known IRF7 activator) reactivates the circuits leading to M2 conversion by improving the resolution of pro?inflammatory cytokines expressed by microglia ex vivo and in vivo, following acute CNS insult.
Importantly, the anti-inflammatory activity of IFN-? was demonstrated in-vivo, when administrated 24h following the primary insult, proposing a relatively large therapeutic window.

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  • Prof. Michal Schwartz-Eisenbach
1597
Metal-oxide material generates electromechanical stress an order of magnitude above existing materials.The ability to develop a mechanical stress in response to the application of an external electric field has many uses, and characteristic materials are classified as either piezoelectric or...

Metal-oxide material generates electromechanical stress an order of magnitude above existing materials.The ability to develop a mechanical stress in response to the application of an external electric field has many uses, and characteristic materials are classified as either piezoelectric or electrostrictive. Modern inorganic piezoelectric devices are used for a wide variety of applications from inexpensive speakers and headphones, to sophisticated sonar transducers. Over the last several decades, these materials have become highly reliable and technologically mature, but the magnitude of the mechanical stress they can generate in response to an input electric signal has reached an upper limit.This innovative technology applies Gadolinium-doped Cerium Oxide (Gd-doped CeO2) to piezoelectric and electrostrictive devices and will enable high-performance electromechanical materials with output capabilities an order of magnitude above existing solutions, in excess of 500 MPa. This could facilitate the next generation of many consumer and industrial electronic devices.

Applications


  • Wide range of personal electronic devices
  • Industrial and fine electronics – specifically powerful acoustic transducers

Advantages


  • Generate large displacement and large stress simultaneously
  • Sensitive and tunable properties

Technology's Essence


In piezoelectric devices, stress develops due to the deformation of a non-centrosymmetric lattice under the application of an electric field. In commercial electrostrictors, or materials with centrosymmetric lattices and very large dielectric constants, an external electric field distorts the unit cells of the lattice, rendering them locally non-centrosymmetric. In both cases, the electromechanical stress develops due to a small displacement of atoms within each unit cell. Increasing the magnitude of the response would lead to more powerful actuators, and permit a decrease in the operating voltage; therefore, the search for novel mechanisms of electromechanical response in solids remains an important objective for both fundamental and applied science.

We have demonstrated that Gd-doped CeO2, specifically Ce0.8Gd0.2O1.9, can generate stress an order of magnitude greater than the best electromechanically active materials. The large stress develops in response to the rearrangement of cerium-oxygen vacancy pairs and their local environment. This effect is expected to be two-fold; i) an applied electric field results in strain and stress directly, and ii) application of the external electric field affects the elastic modulus of Ce0.8Gd0.2O1.9 by suppressing the chemical strain effect. This is a fundamentally different mechanism than materials currently in use. In this view, Gd-doped CeO2 is representative of a new family of high-performance electromechanical materials.

 

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  • Prof. Igor Lubomirsky
1643
Improving beta cell isolation and purification techniques is a critical step towards the development of new cell-based therapies, diagnostic applications and diabetes research. Pancreatic Islets are composed of mixed cell populations, among them beta cells, which represent a major focus of interest due...

Improving beta cell isolation and purification techniques is a critical step towards the development of new cell-based therapies, diagnostic applications and diabetes research. Pancreatic Islets are composed of mixed cell populations, among them beta cells, which represent a major focus of interest due to their participation in the pathology of diabetes. Various techniques have been suggested to accomplish this step, yet efficient and robust isolation of beta cells remains a challenging task.
The present invention provides an efficient tag-free isolation method for pancreatic cell sub-types, based on separation according to a newly identified collection of surface markers. These markers are tightly correlated with specific functions, such as insulin production, ensuring enrichment of the desired functionality.
Probing against the newly identified markers in a combinatorial manner allows high degree of purity without compromising the yield, significantly increasing the amount of purified cells. Finally, the method is compatible with both extracts of pancreatic tissues and stem cells derived cultures, the latter set up high expectations in the diabetes therapy field.

Applications


A kit for isolation of distinct pancreatic cell subtypes

Advantages


  • High purity without compromising the yield of isolated cells.
  • Compatible with a variety of heterogeneous sources including cells extracted from pancreatic tissue, committed lineages of stem cells and cultures of differentiated stem cells.                                               

Technology's Essence


Using an innovative high throughput screen, linking specific cell surface markers with a particular functionality (e.g. insulin production), a collection of markers not previously identified in connection with pancreatic cells or with diabetes was found to be consistently expressed in human islets.
Cell isolation according to the selected markers is performed by exposing the heterogeneous source of cells to specific antibodies that recognize these markers, followed by a choice of sorting techniques such as fluorescence activated cell sorting (FACS).
The innovative concept of this method is the use of marker combinations, iterating the selection. Only cells that express both markers will be sorted out, thus increasing specificity and reducing contaminations. This increased specificity gives rise to a higher degree of purity without compromising the yield, resulting in larger amounts of isolated cells.
By applying the initial screen in yet another iteration, additional markers can be added to the selection, to refine the isolation procedure. 
As this method is generally applicable to the purification of mature as well as pluripotent or partially differentiated beta cell progenitors, it holds great potential for the isolation of clinically relevant cells for treatments of diabetes.

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  • Prof. Michael Walker
  • Prof. Michael Walker
1551
A novel set of manganese, ruthenium and related borohydride complexes (Pincer-type) were developed as remarkably efficient and environmentally-benign catalysts for the synthesis of alcohols, amines, amides, imines and esters, which are the basic building blocks for the research, chemicals,...

A novel set of manganese, ruthenium and related borohydride complexes (Pincer-type) were developed as remarkably efficient and environmentally-benign catalysts for the synthesis of alcohols, amines, amides, imines and esters, which are the basic building blocks for the research, chemicals, pharmaceutical and agrochemical industries. In addition, a catalytic carbon-carbon bond formation using non-activated aliphatic nitriles and carbonyl compounds was achieved with the manganese complex. These reactions are conducted under mild and neutral conditions, using low catalyst loading, require no hydrogen acceptors or oxidants, employ no corrosive or toxic reagents and generate no waste. Moreover, manganese is one of the most abundant transition metals on earth crust, making it appealing and biocompatible when considering a system for eventual scale-up and industrial use.

In view of global concerns regarding economy, environment and sustainable energy resources, there is an urgent need for the discovery of new catalytic reactions. These newly developed catalysts address key problems of current traditional synthetic methodologies, both from the economic and the environmental aspects.

Applications


·         Pharmaceuticals

·         Dyes

·         Cosmetics and fragrances

·         Fibers

·         Agrochemicals


Advantages


·         Cost-effective in terms of reagents, reactions conditions (low temperature and pressure) and waste treatment (green reactions).

·         New synthetic pathways that were not possible before, such as the synthesis of amides and imines directly from alcohols and amines, esters synthesis from alcohols and methanol synthesis from CO2 and hydrogen.

·         Broad substrate scope.

·         Excellent yields.


Technology's Essence


Prof. David Milstein’s group has discovered a new mode of action for metal-ligand cooperation, involving aromatization–dearomatization of ligands. Pincer-type, pyridine-based complexes of Mn, Ir, Rh, Ru, Pd, Pt and acridine complexes of Ru have been shown to exhibit such cooperation, leading to facile activation of C-H, C-C, H-H, N-H, O-H bonds, and to novel, environmentally friendly reactions catalyzed by Mn and Ru.

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  • Prof. David Milstein
1582
Over-expression of an oil globule protein for increased production of oil. Oil globules are discrete organelles, ubiquitous in animals, microorganisms and plants. Plant oil globules contain specific proteins that are tightly bound to their surface. These proteins are suggested to have different roles,...

Over-expression of an oil globule protein for increased production of oil.

Oil globules are discrete organelles, ubiquitous in animals, microorganisms and plants. Plant oil globules contain specific proteins that are tightly bound to their surface. These proteins are suggested to have different roles, including globules formation, degradation and stabilization. The present invention relies on the fact that oil globule associated proteins stabilize the oil bodies, and suggests the induction of one of these proteins as a means to obtain high yields of oil globules. 

Applications


  • Higher yields of oil for food and biodiesel

  • Higher yield of the pigment astaxanthin or beta carotene in pigment-accumulating algae


Advantages


  • Obtaining valuable materials (oil and pigments) with a relatively simple manipulation (i.e., over-expression of the globule-associated protein)
  • Cost-effective

Technology's Essence


In many microorganisms (e.g., yeasts, micro-algae and bacteria), the accumulation of oil globules appears to be induced specifically in response to environmental stresses such as nutrient limitation, high irradiance or osmotic stress. One specific protein, found only in micro-algae, was enriched in isolated globules and in stressed cells, in correlation to astaxanthin accumulation. This correlation makes the protein a promising candidate to function in stress response, and more specifically, in globule buildup. Therefore, it may be expected that its over-expression in plants or in algae could increase the accumulation of oil (tryglycerides).

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  • Prof. Uri Pick
1621
Novel treatment for angiogenesis-related diseases.Angiogenesis — the growth of new blood vessels from pre-existing vasculature — has an essential role in development, reproduction and repair. Pathological angiogenesis is a common theme in a broad range of diseases such as cancer, autoimmune diseases,...

Novel treatment for angiogenesis-related diseases.Angiogenesis — the growth of new blood vessels from pre-existing vasculature — has an essential role in development, reproduction and repair. Pathological angiogenesis is a common theme in a broad range of diseases such as cancer, autoimmune diseases, age-related macular degeneration and atherosclerosis. The global market for angiogenesis stimulators and inhibitors is forecast to reach ~US $50 billion by the year 2015. Most of the currently marketed angiogenesis regulators, such as Avastin, typically display modest efficacy and therefore further highlight the great need for the development of novel therapeutics. The current technology presents a novel method to treat angiogenesis-related disorders by modulating apolipoprotein B (ApoB).

Applications


  • ApoB is a potential therapeutic target for the treatment of cancer and other non-neoplastic diseases.
  • ApoB levels may serve as a biomarker for cancer metastasis.

Advantages


  • The anti-angiogenic effect of LDL administration was demonstrated in vivo, in zebrafish models, as well as in vitro, in relevant human cells lines.
  • Regulation of ApoB levels may be applied to treat a broad range of angiogenesis-dependent diseases.
  • Detection of ApoB levels can be readily achieved by analysis of body fluids such as blood and plasma.

Technology's Essence


Using a high-throughput genetic screen for vascular defects in zebrafish, researchers at the Weizmann Institute of Science have identified a genetic mutation that leads to excessive angiogenesis. The mutated gene is responsible for the assembly of ApoB-containing lipoproteins such as LDL, otherwise known as the ‘bad’ cholesterol. The group has found that low levels of LDL promote the formation of new blood vessels by directly interacting with the VEGF pathway. The outlined technology offers methods to modulate the levels of ApoB in order to stimulate, or inhibit angiogenesis, dependent on the therapeutic strategy. For example, inhibition of angiogenesis by increasing ApoB levels may repress tumor growth and attenuate its metastatic potential. In another application of this technology, increased circulating levels of ApoB can serve as a biomarker for the overproduction of blood vessels, thus enabling early diagnosis of pathogenic states in angiogenesis-dependent diseases.

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  • Dr. Karina Yaniv
1602
A novel technology for robust downregulation of bacterial genes.RNAi (RNA interference) is a powerful method for downregulation of gene expression in eukaryotic systems. RNAi-based technologies are extensively applied as scientific research tools, as well as actively explored as promising therapeutic...

A novel technology for robust downregulation of bacterial genes.RNAi (RNA interference) is a powerful method for downregulation of gene expression in eukaryotic systems. RNAi-based technologies are extensively applied as scientific research tools, as well as actively explored as promising therapeutic agents. However, although an efficient way to dowregulate bacterial and microbial gene expression has been long sought after, RNAi is not applicable in these species. The present technology offers a rapid and simple means to silence gene products in prokaryotic systems.

Applications


  • Treatment of bacterial infection, by targeting bacterial genes vital for antibiotic resistance or bacterial virulence.
  • Enhanced biofuel production by targeting genes that interfere with ethanol and/or hydrogen biosynthesis.
  • Generation of improved bacterial strains for the diary industry (e.g. phage-resistant strains).
  • Discerning prokaryotic gene function by silencing the expression of the gene product.

Advantages


  • The present technology may offer means to treat antibiotics-resistant strains.
  • Because CRISPR-based technology does not involve ‘classical’ genetic engineering, the resulting products do not require labeling as 'genetically modified'.
  • CRISPR-based technology system allows for the development of a rapid, scalable and high-throughput platform to probe the function of genetic circuits in prokaryotes.

Technology's Essence


CRISPR (clusters of regularly interspaced short palindromic repeats) is a recently discovered anti-viral system that functions as the prokaryotic-equivalent of the adaptive immune system. CRISPR provides bacteria with protection against foreign genetic elements such as viruses by incorporating short stretches of invading DNA sequences in genomic CRISPR loci. These integrated sequences are thought to function as a genetic memory that prevents the host from being infected by the viruses and other genetic elements containing this recognition sequence. A team of researchers at the Weizmann Institute, headed by Dr. Rotem Sorek, has developed a unique technology to gain robust and rapid silencing of prokaryotic gene expression by exploiting the CRISPR system capacity to efficiently downregulate gene products. This potent technology can potentially be utilized in a broad range of areas such as in the agriculture, food and pharmaceutical industries as well as in the scientific research arena.

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  • Prof. Rotem Sorek
1646
Dedicated and highly efficient EPR analysis of small volume samples in a range of few µl is now made simple with a novel device invented at the Weizmann Institute of Science. This device features a new ejection mechanism and a unique cold trap which enables collection of all time points in a RFQ series...

Dedicated and highly efficient EPR analysis of small volume samples in a range of few µl is now made simple with a novel device invented at the Weizmann Institute of Science. This device features a new ejection mechanism and a unique cold trap which enables collection of all time points in a RFQ series in one continuous experiment.
In order to design and develop inhibitors for therapeutic purposes, the reaction mechanisms of enzymes must be understood. For biological applications, a common methodology of addressing this need is combining Rapid Freeze Quench with Electron Paramagnetic Resonance (RFQ)-EPR, which allows the trapping and analysis of short lived intermediates in chemical reactions. However, commercial RFQ-EPR devices are limited for high field EPR applications due to the demand of large sample volumes for each time point.
Prof. Goldfarb and her team built a new RFQ apparatus based on microfluidic flow and unique ejection and freezing systems, which can be used for collecting small volume samples in capillaries for high field EPR.

Applications


This technology, combined with the variety of W-band high resolution EPR technique (ENDOR, DEER and ESEEM) enables better mechanistic studies of enzymatic reactions, with an emphasis on structural transformations during the reaction, in an efficient and accurate way.


Advantages


  • Collecting all RFQ time points in one continues experiment.
  • Produce small volume samples in the range of a few µl, and handles small capillaries, for high field ERP.
  • An improved dead time of ~5ms, relative to the commercial RFQs with a typical dead-time of 5–10 ms.
  • Ease-of-use and speed.

Technology's Essence


The innovative apparatus consists of two main parts: the microfluidic device and the freeze-quench setup. The microfluidic device comprises a mixer, which mixes the two reacting solutions, a flow path where the reaction occurs, and a sprinkler from which the solution is sprayed out of the device. Prof. Goldfarb and her colleagues improved the common mixing device by adding a fast stream of nitrogen gas which mixes with the ejected reaction solution, and sprays the frozen aerosol out in tiny drops at high speed.
The innovative RFQ device was planned to have a cold solid surface on which the freezing happens rather than the traditional ejection into a cold liquid, in order to minimize the losses of the frozen solution. Moreover the plate rotates at a speed correlated to the flow speed of the solution, thus samples of different reaction times can freeze on a different radius. The frozen samples are then collected into quartz capillaries.

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  • Prof. Daniella Goldfarb
1555
Albumin binding probe for extending the lifetime of drugs. Most polypeptide drugs, in particular non-glycosylated proteins of molecular mass less than 50 kDa, are short-lived species in vivo having circulatory half lives of 5-20 min. Drug association with endogenous albumin may be suitable for...

Albumin binding probe for extending the lifetime of drugs. Most polypeptide drugs, in particular non-glycosylated proteins of molecular mass less than 50 kDa, are short-lived species in vivo having circulatory half lives of 5-20 min. Drug association with endogenous albumin may be suitable for designing an approach to protract the action in vivo of, potentially, any short-lived peptide/protein drug. In doing so two principal obstacles must be overcome: (1) following its conjugation, the probe introduced into a peptide or a protein should have sufficient affinity to albumin to manifest prolonged action in vivo, and (2) in case such covalent introduction results in an inactive product, the latter should be capable to undergo slow reactivation at physiological conditions. The present invention relates to engineering prolonged-acting prodrugs employing an albumin-binding probe that undergoes slow hydrolysis at physiological conditions.

Applications


  • Prolonging half life of short-lined drugs

Advantages


  • Prolonging the action of the drug without effecting its activity 
  • A desirable pharmacokinetic pattern

Technology's Essence


Since albumin is long-lived in vivo, drugs and endogenous substances that tightly associate with it have lower clearance rates than that of the unbound substances, and exhibit prolonged lifetime profiles in vivo. The present invention is based on a concept according to which a long chain fatty acid (LCFA) like albuminbinding compound is covalently linked to a short-lived amino-containing drug to form a non-covalent drug conjugate capable of associating with albumin in vivo, i.e., a long-lived prodrug that gradually releases the pharmacologically active constituent. This approach has been successfully implemented with several drugs (e.g. insulin, exendin and gentamicin).

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  • Prof. Matityahu Fridkin
  • Prof. Yoram Shechter
1585
Our scientific team has discovered a method to apply the Gabor Transform to signal processing and data compression. Compared to existing methods that are based on Fourier transform, the new method provides for up to 25% savings in content size for video, audio and images, without any loss in quality...

Our scientific team has discovered a method to apply the Gabor Transform to signal processing and data compression.

Compared to existing methods that are based on Fourier transform, the new method provides for up to 25% savings in content size for video, audio and images, without any loss in quality.

By embracing our method, content providers, ISPs and mobile carriers can achieve major savings in data storage and data transfer costs.

Applications


The method can be used in virtually all applications involving data storage, communication and signal processing. One of the main commercial application is for lossy data compression for video, audio and images. Those types of content constitute the bulk of today’s Internet traffic, and improved compression will generate substantial savings in storage and data transfer costs.

The method also applies to the storage, communication and processing of quantum information and may therefore be expected to have applications in quantum calculations, quantum communication and quantum information processing.


Advantages


Existing data compression methods are based on numerical implementations of the Fourier transform, known as FFT, DCT and similar.

Compared to these methods, Gabor transform method demonstrates a very significant advantage in terms of the size of compressed material.  

The method provides for up to 25% savings in data size, while keeping the same perceived quality of the content.


Technology's Essence


We have discovered the definitive solution to the problem of obtaining accuracy and stability in the Gabor transform.  We realized that there must be an exact informational equivalence between the Gabor transform and the discrete Fourier transform (DFT). The latter is known to provide an exact representation of functions that are band-limited with finite support.  Since the DFT implicitly assumes periodic boundary conditions, to obtain this exact equivalence one needs to modify the Gaussians in the Gabor transform to obey periodic boundary conditions. This leads to Gaussian flexibility with Fourier accuracy --- precisely what has been sought since 1946.

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  • Prof. David J. Tannor
1629
A new unsupervised learning tool for analyzing large datasets using very limited known data via clustering was developed by the group of Prof. Domany. This solution was originally demonstrated for inferring pathway deregulation scores for specific tumor samples on the basis of expression data.Nearly...

A new unsupervised learning tool for analyzing large datasets using very limited known data via clustering was developed by the group of Prof. Domany. This solution was originally demonstrated for inferring pathway deregulation scores for specific tumor samples on the basis of expression data.
Nearly all methods analyze pathway activity in a global “atomistic” manner, based on an entire sample set, not attempting to characterize individual tumors. Other methods use detailed pathway activity mechanism information and other data that is unavailable in a vast majority of cancer datasets.
The new algorithm described here transforms gene-level information into pathway- level information, generating a compact and biologically relevant representation of each sample. This can be used as an effective prognostic and predictive tool that helps healthcare providers to find optimal treatment strategies for cancer patients. Furthermore, this method can be generically used for reducing the degrees of freedom in order to derive meaningful output from multi-dimensional data using limited knowns.

Applications


  • Personalized cancer treatment.
  • A tool for mining insight from large datasets with limited knowns.

Advantages


  • Provides personalized solutions.
  • Can be utilized for rare conditions with very limited known information.
  • Proved on real oncologic datasets.
  • A Generic unsupervised learning tool.

Technology's Essence


The algorithm analyzes NP pathways, one at a time, assigning a score DP(i) to each sample i and pathway P, which estimates the extent to which the behavior of pathway P deviates from normal, in sample i. To determine this pathway deregulation score the expression levels of those dP genes that belong to P using available databases are used. Each sample i is a point in this dP dimensional space; the entire set of samples forms a cloud of points, and the “principal curve” that captures the variation of this cloud is calculated. Then each sample is projected onto this curve. The pathway deregulation score is defined as the distance DP(i), measured along the curve, of the projection of sample i, from the projection of the normal samples.

 

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  • Prof. Eytan Domany
  • Prof. Eytan Domany
1559
The Weizmann Institute is actively seeking a company interested in commercializing a novel technology that reduces sulfur content in refined fuels. Fossil fuels sources such as oil, coal, natural gas, shales and others contain varying amounts of sulfur compounds. As world reserves of high quality...

The Weizmann Institute is actively seeking a company interested in commercializing a novel technology that reduces sulfur content in refined fuels. Fossil fuels sources such as oil, coal, natural gas, shales and others contain varying amounts of sulfur compounds. As world reserves of high quality fossil fuels diminish and regulatory standards tighten on reduced levels of sulfur containing emissions, the need for effective methods for removal of refractory sulfides from refined fuels arises.

This invention makes use of a catalytic reaction to remove refractory sulfides from refined fuels thereby enabling the reduction and removal of sulfides. The catalyst is then purified by aerobic oxidation (low temperature combustion) and reused.

Applications


  • Desulfurization of fuels in oil refineries - useful for deep desulfurization of fuels containing relatively small amounts of organic sulfur compounds.

Advantages


  • The process does not require high pressure hydrogen and can be carried out at low temperature.

  • The process complements present HDS technology tp remove refractory sulfides.

  • Catalyst recovery and recycle is carried out by low temperature pyrolysis.

  • No need for additional separation or adsorption processes.

  • No need for additional fuel drying steps.


Technology's Essence


The invention relates to a method for removing heteroaromatic, refractory sulfides down to sub-ppm levels from refined fuels such as gasoline, diesel oil and kerosene. The process uses a heterogeneous catalyst that reacts with the refractory sulfides and oligomerizes or polymerizes them to insoluble polymers that are adsorbed on the catalyst. After use, the catalyst is recovered and purified by low temperature aerobic total oxidation (combustion) reused. This process completes desulfurization of fuels in oil refineries.

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  • Prof. Ronny Neumann
1610
A novel method for increasing Insulin content in pancreatic beta cells. In healthy individuals, Insulin is produced by beta cells of the pancreas. In people with type 1 diabetes mellitus (T1DM), these cells do not produce enough Insulin to effectively fine-tune blood sugar levels. In the US alone...

A novel method for increasing Insulin content in pancreatic beta cells.

In healthy individuals, Insulin is produced by beta cells of the pancreas. In people with type 1 diabetes mellitus (T1DM), these cells do not produce enough Insulin to effectively fine-tune blood sugar levels. In the US alone there are up to 3 million affected individuals with 30,000 new cases diagnosed each year. Worldwide, T1DM incidence has been increasing in recent years by 2% to 5%. Traditionally treated by multiple daily injections of recombinant Insulin, T1DM management represents a significant burden to both patients and the healthcare system. Recent data estimate that T1DM costs the US ~$15 billion annually in medical costs and lost income. Thus, novel therapeutic approaches to amplify Insulin production in diseased beta cells or to replace them entirely are in great need. The present technology describes a cell-based method to enhance beta cell differentiation and Insulin production by the downregulation of a pancreas-enriched microRNA.

 

Applications


  • Cell replacement therapy: directed differentiation of stem cells towards a beta cell fate followed by transplantation of these engineered cells into patients.
  • These methods can potentially be applied to other Insulin deficiency-related conditions such as diabetes mellitus type 2, metabolic syndrome and obesity.

Advantages


  • Simple and robust method for accelerating beta cell differentiation.
  • Cell base therapy for diabetes.
  • Increasing Insulin level.

Technology's Essence


A research team headed by Dr. Hornstein from the Weizmann Institute has discovered an essential role for microRNA-7 (miR-7), a microRNA that is highly and selectively expressed in the endocrine pancreas, in the regulation of beta cell differentiation. By down-regulating the expression of miR-7, the researchers were able to accelerate beta cell differentiation, and concomitantly to augment their Insulin production rate. The data gained from these studies can be further utilized in cell-based therapy applications to restore Insulin production in damaged beta cells, or alternately to replace these cells with stem cells coaxed to differentiate towards a beta cell fate.

 

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  • Dr. Eran Hornstein

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