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1639
Sphingolipid-peptide conjugates with potent anti-viral activity. According to the WHO, 34 million people around the world are afflicted with HIV, the causative agent of AIDS, with approximately 2.5 million new infections diagnosed each year. The development of new drugs against HIV has been the focus...

Sphingolipid-peptide conjugates with potent anti-viral activity.

According to the WHO, 34 million people around the world are afflicted with HIV, the causative agent of AIDS, with approximately 2.5 million new infections diagnosed each year. The development of new drugs against HIV has been the focus of intense research since its discovery. The market size of HIV-1 treatment is indeed significant with drug sales expected to rise from $13.3 bn in 2011 to $16.7 bn in 2020 in the Western world alone. Nevertheless, there is a highly unmet need for innovative HIV treatment approaches. One such approach is the design of early entry inhibitors that are able to block viral fusion and entry into the host cell. The present technology presents sphingolipid-peptide conjugates (sphingo-peptides) with a potent capacity to interfere with HIV viral fusion.

 

Applications


·         Design of novel HIV therapeutics.

·         Extension of half-life of current HIV fusion inhibitors.

·         Topical blockers of viral transmission.

 


Advantages


  • Blocking viral entry prevents all subsequent intracellular steps, most importantly viral genome integration.
  • Sphingolipid conjugates improve efficacy and half-life of current HIV fusion inhibitors.
  • Sphingopeptides were shown to be effective against certain drug-resistant strains.
  • A unique mode of action that reduces the likelihood of developing resistant strains.

Technology's Essence


The first step in the life cycle of enveloped viruses such as the HIV-1 is entry into their host cells by membrane fusion. Therefore, the dynamic process of HIV fusion and entry represents a valid target for rational drug design. A team of researchers at the Weizmann Institute has developed unique sphingolipid-peptide conjugates that block the fusion of the HIV virus to its host cell membrane. Remarkably, the sphingolipid moiety endowed potent anti-viral activity to otherwise poorly and nonactive peptides. Moreover, the sphingo-peptide inhibitors were shown to be highly effective against both wt as well as drug-resistant HIV strains.

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  • Prof. Yechiel Shai
1536
Designer cellulosomes are synthetic multi-enzyme complexes that can degrade cellulosic biomass efficiently and economically. The goal of second generation biofuel production is to efficiently convert agricultural waste, algae and other cellulosic biomass into sugar monomers.   Cellulosic biomass...

Designer cellulosomes are synthetic multi-enzyme complexes that can degrade cellulosic biomass efficiently and economically. The goal of second generation biofuel production is to efficiently convert agricultural waste, algae and other cellulosic biomass into sugar monomers.

 

Cellulosic biomass pretreated (e.g. with acid) under ideal conditions, still requires very high enzyme doses to provide efficient bioconversion.

The cost of enzymes and pretreatment is a major hurdle in the production of low-cost cellulosic biofuel, competitive with that of fossil fuels or ethanol produced from corn or sugarcane.

 

The complex structure of cellulosic materials is built to resist bacterial hydrolytic enzymes. The cooperation of many types of carbohydrate-active enzymes is required for effective degradation. By designing synthetic cellulosomes, researchers at The Weizmann Institute enhance synergy between carbohydrate-active enzymes to achieve remarkable degradation rates. Their discoveries can lead to highly efficient conversion of cellulosic biomass, and thus have a major impact in the field of food production and sustainable energy.

Applications


  • High-yield, cost-effective conversion of plant cell wall biomass into soluble sugars for the food industry and the production of biofuels and biochemicals.

Advantages


  • Bio-engineered cellulosomes exhibit synergistic degradation activity of natural substrates compared to the combined action of the free wild-type enzymes.

Technology's Essence


The invention involves the conversion of enzymes (cellulases and xylanases) from the free mode to the cellulosmal mode by attachment using a recombinant dockerin molecule. The dockerin-bearing enzymes are incorporated into designer cellulosomes by interacting with a matching cohesion-containing chimeric scaffoldin (scaffoldin subunits contain the cohesin modules that incorporate the enzymes into the cellulosome complex via their resident dockerins). This approach has generated over two fold enhancement of synergistic hydrolysis on plant cell wall cellulosic biomass. These results create new possibilities for designing superior enzyme compositions for degradation of complex polysaccharides into simple soluble sugars.

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  • Prof. Edward A. Bayer
1592
Novel genetically modified crops resistant to environmental friendly herbicides.Weeds are considered to be one of the major causes for crop losses by farmers. It is estimated that weeds cause an overall 12% reduction in crop yields or $33 billion in lost crop annually. With the advent of biotechnology...

Novel genetically modified crops resistant to environmental friendly herbicides.Weeds are considered to be one of the major causes for crop losses by farmers. It is estimated that weeds cause an overall 12% reduction in crop yields or $33 billion in lost crop annually. With the advent of biotechnology, several genetically modified (GM) crops were developed that are insect-resistant or herbicide-tolerant - to make pest and weed control easier for farmers. The major trait sought in GM crops is herbicide tolerance as one component of the weed management system. However, use of herbicide resistant crop does not fully protect from weeds, since herbicide-resistant weeds appear and propagate. The appearance of herbicide resistant weeds warrants the development of novel herbicide-tolerant crops. The present technology provides a method for introducing into plants the artificial resistance toward herbicide amino acids, which are not toxic to humans.

Applications


  • Conferring to transgenic plants resistance to the presence of phytotoxic non-protein amino acids.
  • Herbicide tolerance to meta-tyrosine can be expanded into different types of crops such as wheat, cotton, alfalfa, etc.
  • Development of additional non-protein herbicidal amino acids and crops resistant to these compounds.

Advantages


  • Weed control can be performed with non-hazardous, environment-friendly herbicides.
  • Genetically-modified resistant crops enable the use of non-selective herbicides, allowing for more robust weed management.

Technology's Essence


The method is based on incorporation into the plant’s organelles (mitochondria and chloroplast) bacterial aaRS possessing editing activity toward a given toxic amino acid (aaRS in organelles usually lack such activity). As a proof-of-concept, a genetically modified Arabidopsis thaliana was created, capable of growing in the presence of exogenous meta-tyrosine (a known herbicide) at concentrations that have a deleterious effect on unmodified plant. However, the method is not limited to Arabidopsis thaliana or to m-tyr amino acid only.

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  • Prof. Mark Safro
1615
A new process for the production of catalytic metal coated WS2 nanotubes, using cobalt, palladium, nickel, chromium and noble metals.These metal coated nanotubes were shown to have catalytic activity in different organic reactions including degradation of known organic contaminants (Co coated) and...

A new process for the production of catalytic metal coated WS2 nanotubes, using cobalt, palladium, nickel, chromium and noble metals.
These metal coated nanotubes were shown to have catalytic activity in different organic reactions including degradation of known organic contaminants (Co coated) and Suzuki and Heck coupling reactions (Pd coated).
Since catalytic chemical reactions are at the heart of many processes and industries, and efficient catalysis is essential for both economic and environmental reasons, this development of a new catalytic platform bears a potential to influence many diverse markets.

Applications


  • New and efficient Pd-based catalysts for diverse reactions.
  • New and efficient crude oil HDS catalysts.
  • New and efficient wastewater purification catalysts.
  • Production of activated hybrid WS2 nanotubes with new properties.
  • Tailoring catalytic nanotubes with different band gaps adjusted to different activation and catalysis applications.

Advantages


  • Formation of highly active catalytic nanotubes
  • Utilization of the nanotubes' very large surface area
  • Recruiting specific nanotube semiconducting characteristics for special catalysis requirements

Technology's Essence


The invention involves deposition of metal nanoparticles on prepared WS2 nanotubes (INT-WS2) in a two stage process involving Pd-nanocrystallites assisted activation followed by electroless plating.
In this process WS2 nanotubes are synthesized according to known procedures. The nanotubes are then covered by metal nanoparticles in a simple and straightforward procedure resulting with highly active nanotubes which can be utilized as catalysts for various chemical reactions.
This new hybrid technology opens the way to a new family of highly efficient, tunable catalysts; the INTs large surface area, specific band gap design and choice of metal result in an ability to produce unique tailor-made catalysts, applicable to many different industries. 

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1662
Immunotherapy, that is the use of the immune system to treat cancer, is currently a leading candidate in the combat against cancer. Unlike the toxic effects of both chemotherapy and radiation, immunotherapy is considered to have mild side effects due to its ability to differentiate between healthy and...

Immunotherapy, that is the use of the immune system to treat cancer, is currently a leading candidate in the combat against cancer. Unlike the toxic effects of both chemotherapy and radiation, immunotherapy is considered to have mild side effects due to its ability to differentiate between healthy and cancerous cells. Also, the therapeutic role of the immune system is an essential element in the healing process due to bone marrow transplantation for hematologic malignancies.
However, a more efficacious and less toxic T cells based treatment is required. Effective therapy depends on the functional avidity between T cell receptors (TCRs) and peptide-MHC complex (pMHC). However the natural affinity of TCR is low and they do not naturally undergo the processes that improve antibody affinity, such as somatic hypermutation (SHM). Currently there is no method of increasing the affinity of a TCR to its ligand. Moreover there is no knowledge on how use affinity maturated TCRs for creating anti-tumor reactive cells
This technology presents a method of increasing the affinity of a TCR to its ligand. This is done by subjecting TCR genes to SHM via the enzyme Activation Induced cytidine Deaminase (AID). The technology further provides affinity maturated TCRs (in cell- bound or in soluble form) and their pharmaceutical potential for immunotherapy. 

Applications


  • Generating anti-tumor T cells
  • Generating T cells reactive against selected antigen

Advantages


  • Rapid
  • Effective

Technology's Essence


This novel technology reveals that the affinity of a TCR to its ligand may be increased remarkably by subjecting TCR genes to SHM, directed by AID.
First a nucleic acid construct encoding a TCR gene is expressed in a host cell. Next SHM is used to introduce mutations to the TCR gene. Last, the the cells will be analyzed for affinity maturation by tetramer staining and subsequently sorted by FACS.
There are three parallel approaches to perform affinity maturation for the TCR: (1) Ex-vivo affinity maturation system, using Tet-regulated expression of AID (2) Ex-vivo affinity maturation system, using controlled expression of AID by mRNA electrophoresis (3) In-vitro affinity maturation system, using extracts from cells that are in SHM and recombinant AID.

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  • Prof. Rachel Lea Eisenbach
1568
A new multi-state molecular building block for tomorrow’s electric circuits and memory storage devices was realized. Information technology is the core of many industries today. The main challenge facing this industry is the need for miniaturization, due to an ever increase in information density....

A new multi-state molecular building block for tomorrow’s electric circuits and memory storage devices was realized. Information technology is the core of many industries today. The main challenge facing this industry is the need for miniaturization, due to an ever increase in information density. Molecular information processing and storage is becoming a logical candidate to replace the available methods, by use of molecules as building blocks for “bottom up” approaches. A memory device that exists in multiple stable states with a molecular based assembly was prepared. This can offer new ways in which information is processed (multiple-threads) as well as increasing the information density in random access memory (RAM), storage devices and methods.

Applications


  • Binary and ternary Static Random Access Memory
  • Multi-State Dynamic Random Access Memory

  • Multi-State Flash Memory

  • Multi-State Solid State Drive (SSD)

  • Multi-State Information Processing Units


Advantages


  • Low manufacturing cost

  • Robustness

  • Optical read out allows fast data transfer, and non destructive information access

  • Short response time and fast read-out.

  • System is easy to reset

  • Little material is needed/ environmentally friendly.

  • The system can be integrated with other electronic circuits

  • Multi-valued information storage

  • Increase in information density, with no need for additional spatial requirements.

  • Alternative to silicon  technology


Technology's Essence


Electronically addressable multi-state memory for sequential logic flip-flop, flip-flap-flop circuits, and higher order switchable memory circuits,  can be constructed by materials composed of a molecular based assembly that can exist in multiple states. Since the optical output is a precise function of the applied voltage, multi-valued information can be written on to the assembly by applying specific potential biases. The read and write cycle is completed by monitoring the induced optical changes of the system. This system uses the same electrical inputs as conventional memory devices and uses an optical read-out which is non destructive and fast. The properties of the device can be used to create an apparatus for information storage especially with respect to developing solid-state drives in computers (SSDs).

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  • Prof. Milko E. Van der Boom
1596
A beam of light has several properties which can be measured for a variety of applications. The most commonly measured properties of light include Intensity, Color, Phase, and Polarization.In recent years there has been a growing demand to have well-defined optical beams. In order to accomplish this a...

A beam of light has several properties which can be measured for a variety of applications. The most commonly measured properties of light include Intensity, Color, Phase, and Polarization.In recent years there has been a growing demand to have well-defined optical beams. In order to accomplish this a light beam requires fast, accurate, and simple measurement techniques to fully characterize it’s properties.Currently, the ability to measure light polarization exists only qualitatively and at only one specific point in a light beam. Our scientific team has developed a new method to measure changing light polarizations in real-time. 
Our demonstrated system presents a simple way to continuously measure and quantify light polarizations in real-time, throughout the entire length of a light beam. This method has the potential to set a new industry standard, and could lead to a number of applications that were previously not possible.
 

Applications


  • Molecular imaging
  • Medical and industrial lasers
  • Non-destructive testing
  • Analytical chemistry
  • Fiber-optic communications
  • Cryptography
  • Astronomy

Advantages


  • Proved accuracy
  • Simple technique
  • Compact configuration
  • Incorporate into existing equipment
  • Can measure fully polarized, partially polarized, and un-polarized light
  • Two modes of operation:   Space-variant polarization measurements and Wavelength-variant polarization measurements

Technology's Essence


Our polarization measurement technique is based on splitting an input light beam into six parallel beams, each having a predetermined shift in the polarization state with respect to the other beams. The beam components are simultaneously detected using a pixel matrix, such as a CCD camera, to determine their intensity distribution. From this, the polarization state distribution along the cross-section of the input optical beam is determined and we can calculate the Stokes parameters, a set of values which defines polarized light. This allows us to characterize and quantify fully polarized, partially polarized, and un-polarized light at every point in the beam in real-time, with either static or dynamic polarization states. Our method can be applied for two conditions of varying polarizations – changing with position (space-variant) or changing in color (wavelength-variant).

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  • Prof. Nir Davidson
1641
A novel RNA-seq method enables unbiased identification and characterization of cell populations from low-quantity samples (~1000 cells). Utilizing tag-free FACS sorting, researchers at the Weizmann Institute are able to create single cell cDNA libraries in under two hours and at a low cost. As...

A novel RNA-seq method enables unbiased identification and characterization of cell populations from low-quantity samples (~1000 cells). Utilizing tag-free FACS sorting, researchers at the Weizmann Institute are able to create single cell cDNA libraries in under two hours and at a low cost.

As personalized medicine requires analysis of minute RNA quantities from patients, there is a great need for unbiased and comprehensive analysis of cells’ transcriptome from low-quantity samples.  Attaining simultaneous observation on millions of cells in their native context is currently a laborious and expensive process. Therefore an unbiased functional characterization of In vivo cell populations is of great demand.

The Researchers have successfully addressed this challenge in a top down fashion by focusing on cell types. Using broad sampling of single cell transcriptional states from multi-cellular tissues they could reconstruct biological functions. They suggest a straightforward path to construct an unbiased map of functional cell states that are sampled directly from their native context. Thus they reveal a new methodology for microscopic analysis of the transcriptome in heterogeneous tissues.

Applications


The innovative technology has potential applications in basic research, personalized medicine and clinical diagnostics -

·         Kits for single cell transcriptome analysis of FACS output.


Advantages


·         Dramatic reduction is costs and labor.

·         High resolution, robust.

·         Top down, unbiased.

·         No need to use markers.


Technology's Essence


This technology combines an automated 384-well cell capture and library preparation assay, two-tier molecular and cellular labeling and efficient poly-A tailed RNA conversion.  Amplification and sequencing of multiplexed libraries is achieved with 1000 cells in a single experiment.  Notably, each read in this method is directly interpretable as representation of a single RNA molecule from a specific single cell. The result is highly practical profiling of large cells samples. This further enables robust characterization of subpopulations’ functional state (at a resolution of 10 cells or 1% of 1000 cells sample).

Moreover the researchers have developed a computational framework that aggressively filters noise and potential biases in the data using randomized molecular labels (RMT) and controls for different sources of amplification and inter-cell contamination errors.
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  • Prof. Ido Amit
  • Prof. Ido Amit
1546
Improvement of protein production by modulating the tRNA pool. For maximal heterologous expression of proteins per host cell, the optimal level of expression of genes needs to be addressed. The science and art of expressing a gene from one species in another often amounts to modifying the codons of the...

Improvement of protein production by modulating the tRNA pool. For maximal heterologous expression of proteins per host cell, the optimal level of expression of genes needs to be addressed. The science and art of expressing a gene from one species in another often amounts to modifying the codons of the gene, and supplementing the host with specific tRNAs. Yet the full challenge of heterologous expression is not only to maximize expression per host cell, but also to minimize the burden on the host. The outlined invention describes a universally conserved profile of translation efficiency along mRNAs, based on the adaptation between coding sequences and the tRNA pool, to improve heterologous gene expression and thus protein production.

Applications


  • Improvement of the yield and success rate of recombinant protein production.

Advantages


  • Protein expression levels can be artificially increased
  • Minimization of the burden on the host

Technology's Essence


The translation efficiency profile of a gene is defined, for each codon position, as the estimated availability of the tRNAs that participate in translating that codon. The profile is high at codons that correspond to abundant tRNAs and low at codons that correspond to rare tRNAs. In this invention it is predicted that the first ~30-50 codons of genes appear to be translated with a low efficiency “ramp”, while the last ~50 codons show highest efficiency. The “ramp” serves as a late stage of initiation and is an optimal and robust means to reduce ribosomal traffic jams, thus minimizing occupation of free ribosomes, ribosomal abortions and, ultimately, the cost of protein expression. Implementation of appropriate ramping in heterlogous proteins, given the host?s tRNA pool, might improve the yield of expressed recombinant proteins.

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  • Prof. Yitzhak Pilpel
1618
A novel method is disclosed here for boosting the immune response, useful not only for the treatment of microbial and chronic viral infections, but also for activating the immune system against cancer cells. TLR-4 is a central player in the innate immune system as it specifically recognizes...

A novel method is disclosed here for boosting the immune response, useful not only for the treatment of microbial and chronic viral infections, but also for activating the immune system against cancer cells. TLR-4 is a central player in the innate immune system as it specifically recognizes lipopolysaccharide (LPS), the major cell wall component of Gram-negative bacteria, and activates the immune system. Newly developed peptides derived from the N-terminus of a TLR-4 trans-membrane domain are capable of activating TLR-4 mediated immune response, thus useful both as stand-alone treatments and as vaccine adjuvants, increasing the immunogenicity of an antigen in a vaccine. Taken together, the newly developed peptides are useful for the treatment and prevention of a large variety of infections, such as microbial (e.g. Salmonella, Escherichia, Pseudomonas), viral (including HIV, Hepatitis and Influenza) and fungal infections. Further, they are useful in the treatment and prevention of a wide variety of cancers.

Applications


  • Treatment for a wide variety of infectious diseases and cancers.
  • Prophylaxis for a wide variety of infectious diseases and cancers, as an adjuvant administered together with specific antigen.

Advantages


  • Treats a wide variety of bacterial, viral and fungal infections.
  • Suitable both as a treatment and prophylaxis.
  • Boosts the endogenous immune system
  • Peptides are easy to synthetize and purify
  • Patient-friendly administration, either systemic or local.

Technology's Essence


The technology is based on the discovery that peptides derived from the N-terminus of a TLR-4 TM domain or their analogs are capable of activating TLR-4 mediated immune response. These peptides activate TLR-4 receptor, possibly by dimerizing within the cell membrane and stabilizing the TLR-4 dimer. Through TLR-4 activation, these peptides activate macrophages to secrete TNF-alpha, thereby stimulating the immune system. In addition, the ability of these peptides to modulate the immune system's innate response renders them useful as vaccine adjuvants, increasing the immunogenicity of an antigen in a vaccine.

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  • Prof. Yechiel Shai
1577
A novel desulfurization system achieves removal of sulfur dioxide (SO2) from industrial exhaust streams at efficiencies that can greatly supersede technologies currently in use. The chemical process is highly selective to SO2, and consumes much less reagents, therefore reducing the cost of...

A novel desulfurization system achieves removal of sulfur dioxide (SO2) from industrial exhaust streams at efficiencies that can greatly supersede technologies currently in use. The chemical process is highly selective to SO2, and consumes much less reagents, therefore reducing the cost of desulfurization.Techniques to capture SO2 from coal-burning plants have not changed in nearly 40 years. Once implemented, the technology presented here can become significantly more efficient and environmentally friendly than existing techniques, since no slurry waste is created from the wet sorbents typically used to capture SO2.The novel system can selectively recycle SO2 into useful sulfur-based compounds which can be resold; utilizing a carbonate eutectic melt this procedure can also be aimed to generate elemental sulfur, an inert and non-toxic compound which can be stored long-term until required for further use.In a world anxious over climate change, yet in demand of more energy, solutions should have the capacity to be implemented quickly and incorporated into existing infrastructure. This technology offers the potential to tackle several problems with one simple solution.

Applications


Integrate into industrial fossil-fuel burning facilities which include:

  • Power plants
  • Cement factories
  • Steel foundries

Advantages


  • Implement into existing infrastructure and reduce reagents’ costs compared to current techniques
  • Significantly higher efficiency and elimination of hazardous waste by-products
  • Potential generation of revenue from recycled Sulfur waste.

Technology's Essence


The significant enhancement of this scrubbing technique is the sequentially operable scrubbing zone and regeneration zone, which communicate with one another via a molten eutectic mixture of lithium, sodium and potassium carbonates. In the scrubbing zone, an ingress flue gas interacts with the molten carbonates, resulting in chemical absorbance of the SO2 and in discharge of reaction gases. In the regeneration zone, either chemical or electrochemical melt regeneration takes place resulting in formation of sulfur containing vapor which is cooled down for converting the sulfur-containing vapor into a liquid and solid phase for a further collection and utilization.The technology developed by Prof. Igor Lubomirsky and his team introduces three essential improvements over past techniques: (i) the removal of sulfate from the melt is achieved at expected operating temperatures of an industrial scrubbing tower (480-550°C), which drastically reduces corrosion of metal components, (ii) the reduction of sulfates by CO gas rather than by carbon powder represents a simpler, one-step process, which results in a high reduction rate and allows for the reaction chamber to be small (few tens of m3 for a 1GW coal plant), and (iii) the removal of sulfate in the form of COS, rather than H2S, provides considerable freedom in choosing the final sulfur product – either sulfuric acid or elemental sulfur.

 

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  • Prof. Igor Lubomirsky
1601
A potent combination therapy against non-invasive breast cancer Breast cancer is the most common cancer in females. Among the different subtypes of breast cancer, ductal carcinoma in situ (DCIS) represents an intermediate step between normal breast tissue and invasive breast cancer. Currently, about 25...

A potent combination therapy against non-invasive breast cancer

Breast cancer is the most common cancer in females. Among the different subtypes of breast cancer, ductal carcinoma in situ (DCIS) represents an intermediate step between normal breast tissue and invasive breast cancer. Currently, about 25% of breast cancers that are diagnosed in the US are DCIS. DCIS is commonly treated by surgical intervention followed by adjuvant radiation therapy. However, a significant fraction of the DCIS lesions, which display HER2 gene amplification, are associated with increased relapse rate following surgery. Therefore, in cases of HER2-overexpressing DCIS a molecularly targeted therapy might be necessary for complete eradication of microscopic remnants following surgical tumor removal. The current technology presents an potential DCIS therapeutic strategy that collectively targets the functionally linked HER2 and Notch pathways.

 

Applications


  • Combination therapy for DCIS patients following surgical tumor removal.
  • Classification of DCIS patients according to HER2 Notch activation patterns to identify patients with increased risk of relapse after surgery.
  • Diagnostic antibodies to NRG4 to screen for cancer cell subtypes that express/over-express NRG4.
  • NRG4 fusion conjugates, where NRG4 acts as a vehicle to direct the conjugate to cells specifically expressing the receptor ErbB4.

 


Advantages


  • Targeted cancer therapies will give doctors a better way to tailor cancer treatment.
  • Targeted cancer therapies hold the promise of being more selective, thus harming fewer normal cells, reducing side effects, and improving the quality of life.
  • The proposed treatment strategy may prove beneficial in DCIS patients with poor prognosis.

 


Technology's Essence


The HER2/Neu oncogene, a member of the HER/ErbB signaling network, encodes a receptor-like tyrosine kinase, whose overexpression in breast cancer predicts poor prognosis and resistance to conventional therapies. Pre-invasive lesions, such as DCIS, overexpress HER2 at higher frequency than invasive ones. Another signal transduction pathway critical for breast cancer progression comprises Notch family receptors and their membrane-bound ligands. In the current technology, a team of researchers from the Weizmann Institute of Science uncovered that overexpression of HER2 in a novel experimental model of DCIS leads to transcriptional upregulation of Notch pathway components, resulting in enhanced tumor cell survival and proliferation. Combined treatment with HER2 and Notch pathway inhibitors resulted in decreased proliferative and tumorigenic potential. The current technology offers specific and combined targeting of HER2 and Notch pathways for DCIS treatment. This approach may also be tailored for DCIS patients with enhanced co-expression of HER2 and Notch.

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  • Prof. Yosef Yarden
1644
Computer memory and storage are among the most critical components of today’s consumer electronics and computer technology. Currently available memory and storage technologies have inherent limitations that confine the capacity and speed of access to memory devices. The present innovation is based on...

Computer memory and storage are among the most critical components of today’s consumer electronics and computer technology. Currently available memory and storage technologies have inherent limitations that confine the capacity and speed of access to memory devices.

The present innovation is based on Chiral Induced Spin Selectivity (CISS) effect that was established experimentally and theoretically in the last decade, and allows for production of inexpensive, high-density universal memory-on-chip devices, that don’t require the use of permanent magnets.

Applications


·         Inexpensive, high-density universal memory-on-chip devices

·         The technology can be used as superior alternative for both Random Access memory and Flash memory

·         Surface-controlled spintronic devices

·         Logic and data processing


Advantages


·         Up to 70 times more storage on the same physical size

·         Up to 100 times lower energy consumption

·         Si-Compatible

·         High density (can reach Si technology limit)

·         Estimated low cost

·         Overcomes limitations of other magnetic-based memory technologies


Technology's Essence


Ferromagnets can be magnetized either by external magnetic fields or by spin polarized current. However, the current density required for inducing magnetization is extremely high and significantly affects the device’s structure and performance. The newly discovered CISS effect allows for magnetization switching of Ferromagnets, which is induced solely by adsorption of chiral molecules, where much lower current density is sufficient to induce the magnetization reversal. Chiral Memory technology uses the CISS effect for spin selectivity instead of the common ferromagnetic-based spin filters. This allows, in principle, the memory bit to be miniaturized down to a single magnetic nanoparticle or a nano-scale domain. The operation principle of the device relies on the spin-selective transmission of electrons through organic chiral molecules to the ferromagnetic layer of the device, which results in the magnetization of this layer and efficient storing of bits of information. The magnetization switching by local adsorption of chiral molecules eliminates the need for a permanent magnet.

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  • Prof. Ron Naaman
1554
We present a novel approach resulting in efficient and robust wireless energy transfer in the mid-range. Applications of wireless energy transfer are already in use and are continuously being developed. The main limit of wireless energy transfer techniques is that both the transmitter and transformer...

We present a novel approach resulting in efficient and robust wireless energy transfer in the mid-range. Applications of wireless energy transfer are already in use and are continuously being developed. The main limit of wireless energy transfer techniques is that both the transmitter and transformer need to be of the same resonance. In addition, this technique is very susceptible to noise which limits efficiency. The present invention provides a technique for a robust and efficient mid-range wireless power transfer between two coils. This technique can transfer the energy between the coils without being sensitive to any resonant constrains, noise and other interferences that exist in the neighborhood of the coils

Applications


  • Simultaneous energy transfer to several electrical gadgets.

Advantages


  • Efficient
  • Not sensitive to electrical interference.
  • No need for an exact resonance match between transmitter and transformer.

Technology's Essence


The efficiency and robustness of this technology is achieved by adapting the process of rapid adiabatic passage (RAP) for a coherently driven two state atom to the field of wireless energy transfer. In other words, the resonance of the transmitter is tuned adiabatically to scan a resonant frequency range, thus arriving at a dynamic solution to the electrical transfer problem.

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  • Prof. Yaron Silberberg
1628
New generation of superior nature-inspired therapeutics for treating inflammation.Inflammation is characterized by elevated levels of TNF-?. Neutralizing TNF-? activity was shown to be beneficial for patients with chronic autoimmune inflammatory diseases such as rheumatoid arthritis (RA) and...

New generation of superior nature-inspired therapeutics for treating inflammation.Inflammation is characterized by elevated levels of TNF-?. Neutralizing TNF-? activity was shown to be beneficial for patients with chronic autoimmune inflammatory diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). However, current treatments of such conditions include general anti-inflammatory and immunosuppressive drugs that are of limited effectiveness and may cause serious side effects. Another class of drugs includes targeted therapies directed against TNF-?, that are associated with serious infections including tuberculosis (TB) and sepsis as well as increased risk of cancer in some cases. Thus, there is an urgent need for highly selective, safer and more effective drugs for inflammatory conditions that involve TNF-? as a key mediator. The present technology introduces a novel generation of candidate drugs that selectively inhibit the processing of TNF-?, thereby preventing it from exerting its pro-inflammatory properties. This technology provides a framework for the development of safer and more effective therapeutics for IBD and related autoimmune disorders.

Applications


  • Treatment of autoimmune inflammatory conditions such as IBD and RA.
  • Treatment of neuroinflammatory conditions such as multiple sclerosis (MS).
  • Treatment of other inflammatory mediated diseases such as psoriasis, systemic sclerosis and ankylosing spondylitis.
  • All MMPs and ADAMs proteases possess an autoinhibitory pro-domain and therefore this technology can be broadened to other MMP and ADAM targets.

Advantages


  • TACE pro-domain is highly potent and efficient.
  • TACE pro-domain is metabolically stable, unlike small molecule inhibitors of TACE.
  • Targeting TACE through nature-inspired protein design may constitute a safer approach to combat TNF-? induced inflammation.
  • Unlike non-specific small molecule inhibitors, which target the conserved catalytic zinc site of TACE, TACE pro-domain shares little homology to other MMPs, making it a good candidate for specific inhibitor of TACE.

Technology's Essence


The A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-? converting enzyme (TACE), has been defined as the major shedding protease for a broad range of substrates predominantly the key immuno-regulatory cytokines TNF-?. Cleavage by TACE renders TNF-? pro-inflammatory, highlighting ADAM17 as a rationale target for treatment of autoimmune diseases such as IBD and arthritis. A team of researchers at the Weizmann institute headed by Prof. Irit Sagi, has employed a sophisticated approach towards TACE targeting by exploiting its autoinhibitory pro-domain as a platform for the ‘smart design’ of TACE selective natural inhibitors. The therapeutic potential of TACE pro-domain was demonstrated in IBD mouse models, where TACE pro-domain administration showed significant improvement in multiple parameters such as reduced mortality and weight lost, in a dose dependent manner. Additional in vivo studies demonstrated that the TACE pro-domain is highly stable in vivo and harbors specificity towards the activated immune cells located in colon lesions. Thus, the novel TACE inhibitor presented in this technology leads to significant therapeutic effects and is beneficial in controlling inflammation in IBD disease manifestations in mice.

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  • Prof. Irit Sagi

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