You are here

Category
Technology Name
Briefcase
Scientist
147
Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception. Monoclonal antibodies for peptide and steroid hormones Due to their high...

Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).
Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Peptide Hormones:

§  147-148 - Monoclonal antibody to hCG

Description: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).

Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

 
+
  • Dr. Fortune Kohen
274
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.   §  127, 274, 141 – Monoclonal...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  127, 274, 141 – Monoclonal antibodies to estradiol         

      Description: Monoclonal antibodies raised against oestradiol-6-     carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b),    8D9 (IgG2a).

Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.

            References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.

            S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304.

+
  • Dr. Fortune Kohen
130
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Veterinary drugs: §  130 - Anti-idiotypic antibody against anti-Sulfamethazine...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Veterinary drugs:

§  130 - Anti-idiotypic antibody against anti-Sulfamethazine

                              Description: Betetypic anti-idiotypic antibody raised against anti Sulfamethazine –KLH (clone 21C7). Available clone: 12E12.

Reference: Fortune Kohen , Batya Gayer , Yehudith Amir-Zaltsman &

Michael O'Keeffe. 2000. Generation of an anti-idiotypic antibody as a surrogateLigand for sulfamethazine in immunoassay procedures, food and agricultural. Immunology 12:3 193-201.

 
+
  • Dr. Fortune Kohen
182
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

Monoclonal antibodies to IgE

Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

+
  • Prof. Zelig Eshhar
257
257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin. Gliomedin, a glial ligand for neurofascin and NrCAM, is...

257 - Monoclonal antibody to Gliomedin

Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin.

Gliomedin, a glial ligand for neurofascin and NrCAM, is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment, aligned with the forming nodes of Ranvier. Gliomedin was shown to induce ion channel organization along the nerve axons, elicit formation of myelin and initiate node formation. Immuno-detection of Gliomedin may be used for diagnostics of neurological pathologies or as a marker for nodes of Ranvier in human and various animal model systems.

Reference: Eshed Y, Feinberg K, Poliak S, Sabanay H, Sarig-Nadir O, Spiegel I, Bermingham JR Jr, Peles E. 2005. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. Neuron. 47(2):215-29.

+
  • Prof. Elior Peles
115
  Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Veterinary drugs: § 115 - Monoclonal antibody to Sulfamethazine (SMZ)...

 

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Veterinary drugs:

§ 115 - Monoclonal antibody to Sulfamethazine (SMZ)

Description: Rat monoclonal antibodies raised against Sulfamethazine-BSA.

    Available clone: 21C7, IgG1.

Sulfamethazine is an antibacterial agents commonly given to food animals (swine, fishetc.) to prevent disease and maximize production.

Reference: Fortune Kohen , Batya Gayer , Yehudith Amir-Zaltsman &

Michael O'Keeffe. 2000. Generation of an anti-idiotypic antibody as a surrogateLigand for sulfamethazine in immunoassay procedures, food and agricultural. Immunology 12:3 193-201.

+
  • Dr. Fortune Kohen
155
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Isoflavones: §  155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin    Description: 7...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Isoflavones:

§  155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin

   Description: 7-(O)-carboxymethyl formononetin is an isoflavone derivative, active as a selective estrogen receptor modulator.

 

 

+
  • Dr. Fortune Kohen
276
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. §  275-276 – Monoclonal antibodies to...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

§  275-276 – Monoclonal antibodies to estrone-3-glucuronide

Description: Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3.

Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.

            References: Geoff Barnard, Fortune Kohen. 1998. Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Clin Chem 44:7 1520–1528.

Barnard G1, Kohen F, Mikola H, L?vgren T. 1989. Measurement of estrone-3-glucuronide in urine by rapid, homogeneous time-resolved fluoroimmunoassay. Clin Chem. 35(4):555-9.

 
+
  • Dr. Fortune Kohen
138
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and progesterone-11- hemisuccinate-BSA (clone 1E11, IgG1).
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Reference: Jozef G. De Boever, Fotune Kohen, Eugene Bosmans. 1994.  Binding of homologous and heterologous isoluminol- and enzyme-labelled  progesterone conjugates to monoclonal antibodies. Analytica Chimica Acta.  290: 239-245

 

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  138,146 – Monoclonal antibodies to Progesterone          

      Description:  Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and progesterone-11- hemisuccinate-BSA (clone 1E11, IgG1).

Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.

      Reference: Jozef G. De Boever, Fotune Kohen, Eugene Bosmans. 1994.      Binding of homologous and heterologous isoluminol- and enzyme-labelled   progesterone conjugates to monoclonal antibodies. Analytica Chimica Acta.    290: 239-245


 

+
  • Dr. Fortune Kohen
186
A DNP-specific murine IgE monoclonal antibody Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody...

A DNP-specific murine IgE monoclonal antibody

Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody binds to mast cells or rat basophilic leukemia cells and, upon binding of DNP-protein, triggers an anaphylactic reaction.

Reference: Eshhar Z, Ofarim M, Waks T. 1980. Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. J Immunol 124(2):775-80.

+
  • Prof. Zelig Eshhar
259
259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr. Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin...

259 - Monoclonal antibody to Caspr

Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr.

Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin sheath attachment along with contactin. May be glycosylated.

Reference: Poliak S1, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E. 1999. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Neuron. 24(4):1037-47.

 

Tech # 1269

+
  • Prof. Elior Peles
117
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Drugs: §  117 – Monoclonal antibody to Digoxin         Description: Rat...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Drugs:

§  117 – Monoclonal antibody to Digoxin

        Description: Rat monoclonal antibodies raised against Digoxin.

        Available clone: 10F10, IgG1.

Digoxin is a purified cardiac glycoside similar to Digitoxin extracted from the foxglove plant, Digitalis lanata. Digoxin is widely used in the treatment of various heart conditions.

 
+
  • Dr. Fortune Kohen
173
181 - Monoclonal antibody to Galectin-8 Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer...

181 - Monoclonal antibody to Galectin-8

Description: Monoclonal antibody to Galectin-8 (clone 106.1).

Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer.  It was shown to trigger the transcription of a unique set of genes, some of which are associated with bone remodeling and prostate cancer progression.

Reference: Levy Y, Arbel-Goren R, Hadari YR, Eshhar S, Ronen D, Elhanany E, Geiger B, Zick Y. 2001. Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem. 276(33):31285-95.

+
1655
Cellular senescence is a permanent cell cycle arrest induced by damage or stress applied on proliferating cells. In a cell autonomous manner, senescence is a potent barrier to tumorgenesis and contributes to the cytotoxicity of some anti-cancer drugs. However, with age senescence cells accumulate and...

Cellular senescence is a permanent cell cycle arrest induced by damage or stress applied on proliferating cells. In a cell autonomous manner, senescence is a potent barrier to tumorgenesis and contributes to the cytotoxicity of some anti-cancer drugs. However, with age senescence cells accumulate and promote a number of pathological conditions. Therefore the elimination of senescent cells is desired in order to prevent tumor- and inflammation- related pathologies and also to inhibit tissue ageing.
Today, our understanding of the mechanisms regulating the viability of senescent cells is limited. It has been suggested that senescent cells are resistant to apoptosis. Therefore, senescent cells elimination may be achieved by modifying the resistance to apoptosis of these cells.
Here the researches demonstrate the first feasible therapeutic approach that leads to eradication of senescent cells. Combination of direct induction of apoptosis in senescent cells with induction of cell death by pro-inflammatory repose induce by p21 knockdown will lead to reduction of viable senescent cells.

Applications


  • A therapeutic impact on inflammatory and fibrotic disease
  • Therapy for age-related disease such as type 2 diabetes, Alzheimer’s disease, Atherosclerosis, cataracts, Chronic obstructive pulmonary disease (COPD), and Osteoporosis

Advantages


  • Effective elimination of senescent cells- removal of senescent cells can prevent or delay tissue dysfunction and extend health span
  • Does not damage normal cells even at high concentrations

Technology's Essence


Researches demonstrated that the anti-apoptotic proteins Bcl-xL and Bcl-w level were elevated in senescence cells of both human and mouse origin. A subsequent study, in which Bcl-xL and Bcl-w were knocked down by siRNA, revealed that a combined knock down of Bcl-xL and Bcl-w had synergic effect, resulting in reduction of 50% in cell viability. Thus the increased level of anti-apoptotic proteins Bcl-xL and Bcl-w may account for the apoptotic resistance of senescent cells. p21 knockdown induced pro-inflammatory response and cell death in senescent cells.
Overall, the researchers show that combined inhibition of the anti-apoptotic proteins Bcl-xL and Bcl-w allows specific elimination of senescent cells and might be used to treat diseases where senescent cells are present. The researchers also found that the same effect might be achieved by reducing the expression of p21 in senescent cells. Integrating both approaches propose a more effective therapy.

+
  • Ph.D. Valery Krizhanovsky
1698
GD is an inherited metabolic disorder, affecting about 1 in 20,000 births. GD is divided into three clinical subtypes: type 1 is the most common and is characterized by bruising, fatigue, anemia, low blood platelets, and enlargement of the liver and spleen. Types 2 and 3, also called neuronopathic GD (...

GD is an inherited metabolic disorder, affecting about 1 in 20,000 births. GD is divided into three clinical subtypes: type 1 is the most common and is characterized by bruising, fatigue, anemia, low blood platelets, and enlargement of the liver and spleen. Types 2 and 3, also called neuronopathic GD (nGD), affect 4% of GD patients and additionally include neurological symptoms. Type 1 patients can have a normal life expectancy if treated whereas type 2/3 patients do not survive to reach adulthood. Moreover, GD carriers, approximately 1% of the population, are in a major risk of developing Parkinson’s disease. Current therapies suffer from severe drawbacks in the treatment of type 1 GD and no therapy exists that effectively treat nGD. The present technology offers a novel therapeutic target for the treatment of Gaucher's disease (GD) which addresses also the neurological symptoms.

Applications


  • Alternative treatment for type 1 GD
  • First line therapy for nGD

Advantages


  • A novel therapy for nGD which has no treatment for the present.
  • A novel therapeutic approach for GD type 1, via a previously unknown molecular mechanism.
  • Allows the development of an orally administered treatment, far more convenient for the patients than the existing treatments.
  • Reduced costs compared to the existing therapies of ERP or BMT

Technology's Essence


The proposed technology is based on the discovery that RIP3 is a key player in the manifestation of GD and that inhibiting RIP3 activity is effectively ameliorating the symptoms of GD not only in the less severe type 1 but also in the neuropathic form of the disease, types 2 and 3. nGD is associated with a massive neuronal loss and elevated RIP3 levels. Inhibition of RIP3 in a mouse model of nGD resulted in a dramatic attenuation of disease signs: drastic extension of life span, no weight loss, improvements in motor coordination, reduced neuroinflammation and improved liver and spleen injuries.

+
  • Prof. Anthony H. Futerman

Pages