You are here

Avaliable Technologies

Category
Technology Name
Briefcase
Scientist
1549
A tailor-made strategy for cancer treatment. The ErbB family of tyrosine kinase receptors and their ligands play important roles in development and tissue remodeling throughout adulthood. ErbB proteins are involved in several types of human cancer. Clinical studies indicate that over-expression of one...

A tailor-made strategy for cancer treatment. The ErbB family of tyrosine kinase receptors and their ligands play important roles in development and tissue remodeling throughout adulthood. ErbB proteins are involved in several types of human cancer. Clinical studies indicate that over-expression of one or more ErbB ligands correlates with decreased patient survival. The currently approved drugs for the treatment of cancers driven by the ErbB family target the receptors rather than the ligands, and they include either monoclonal anti-receptor antibodies, or tyrosine kinase inhibitors (TKIs). Because of resistance and moderate clinical efficacies of anti-receptor antibodies and TKIs it is worthwhile considering alternative strategies. The present technology combines several antibodies, capable of blocking ErbB ligands, with chemotherapy.

Applications


  • Treatment of cancers that possess the ErbB receptors (e.g. colorectal, liver, bladder, and head and neck tumors)

Advantages


  • Effective blockade of the tumorigenic action of ErbB-specific ligands
  • The combination protocol may enhance the sensitivity to chemotherapy

Technology's Essence


In the outlined technology, monoclonal antibodies were generated against two ligands, namely TGF-? and heparin-binding EGF-like growth factor. Combining the two antibodies with a chemotherapeutic drug enhanced the ability of chemotherapy to inhibit pancreatic tumors in mice. Therefore, this technology offers a general cancer therapeutic strategy that entails profiling the repertoire of growth factors secreted by a tumor, and combining with chemotherapy several antibodies capable of blocking autocrine ligands, in a way that sensitizes tumors to cytotoxicity and delays onset of chemoresistance.

+
  • Prof. Yosef Yarden
1783
Aluminum and magnesium alloys are gaining more recognition for light-weight materials applications. In spite of this, such alloys have not been used for critical mechanical applications mainly due to their inferior mechanical properties compared to other engineering materials such as steel. Hence, many...

Aluminum and magnesium alloys are gaining more recognition for light-weight materials applications. In spite of this, such alloys have not been used for critical mechanical applications mainly due to their inferior mechanical properties compared to other engineering materials such as steel. Hence, many researchers have attempted to reinforce these alloys and obtain light-weight materials with excellent mechanical properties. The reinforcement process of the alloy can be achieved by introducing another material to form metal matrix composites. Different studies show that such composites exhibit improved properties, such as increased yield strength and tensile strength, enhanced stiffness, improved thermochemical properties, etc. However, the introduction of nanomaterials into the metal matrix is rather difficult due to the harsh manufacturing conditions employed for processing the metal composites.

The group of Prof. Reshef Tenne has developed state-of-the-art aluminum- and magnesium-based metal matrix composites, comprising small amounts of inorganic nanomaterials, such as nanotubes and spherical nanoparticles. The new nanocomposites exhibit much superior mechanical properties compared to the pristine alloy.

Applications


·         Automotive, transportation, and aerospace industries

·         Jet engine technologies

·         Electronics

·         Medical technologies


Advantages


·         Light-weight metal alloys

·         Excellent mechanical properties

·         Straight-forward fabrication technique


Technology's Essence


Aluminum (AA6061) and magnesium (AZ31) alloys were combined with small amounts (up to 1 wt.%) of either tungsten disulfide nanotubes or inorganic fullerene-like tungsten disulfide nanoparticles to form metal matrix composites using a melt-stirring reactor operated at high temperatures (up to 750oC). These nano-structures exhibit unique mechanical properties, which make their usage as composite fillers very promising, and a remarkable stability at elevated processing temperatures. Despite the small amounts of added nanostructures, their addition led to notable improvements in the mechanical properties of the alloys. Surprisingly, both the tensile strength of the alloys and their elongation (and consequently the fracture toughness) were improved by 10-20%. Depending on the nano-structure type and concentration, the hardness, yielding strength, ultimate tensile strength, and ductility were improved by up to ~70%. Physical considerations suggest that the main mechanism responsible for the reinforcement effect lies in the mismatch between the thermal expansion coefficients of the metal and the nano-structures.

+
  • Prof. Reshef Tenne
1796
Oil is an important commodity in the global economy, used in numerous industries such as energy, cosmetics, food, personal care, and many more. However, oil based on petroleum is problematic due to finite supply, increasing environmental concerns, and regulations. Oils derived (?) from plant sources...

Oil is an important commodity in the global economy, used in numerous industries such as energy, cosmetics, food, personal care, and many more. However, oil based on petroleum is problematic due to finite supply, increasing environmental concerns, and regulations. Oils derived (?) from plant sources tend to compete with valuable arable land and consume fresh water.

Therefore oil sourced from algae as an alternative is an attractive option, as algae does not pollute, does not require arable land, and can use sea water. Yet current methods of producing oil from algae have limited net yields.

The present technology uses the virus EhV201 to modify the metabolism of microalgae Emiliania huxleyi to increase the production of high quality saturated and mono-unsaturated Triacylglycerides (TAGs). The method is simple to apply in increasing TAG content, does not perturb biomass production, and can even simplify the harvesting of the microalgae produced TAGs.

Applications


·         Directed production of Algal Oil from saturated and mono-unsaturated triacylglycerides for the production of high value products in the food, energy, cosmetics, and pharmaceutical industries.

·         Secondary and tertiary products can be co-extracted or generated from the TAGs and microalgae for different industrial uses:

o   Glycerol and fatty acids for food and cosmetics.

o   Algal cake (residual microalgae material) for animal feed, fertilizers, and so on.


Advantages


?  Straightforward procedure

?  High yield

?  No Genetic Modification

?  Simple and economical - no special equipment or conditions to induce TAG production

?  Scalable- as the EhV201 regenerates itself


Technology's Essence


The application of infecting E. huxleyi with EhV201, to increase triacylglyceride (TAG) production represents a promising innovation in creating an alternative source of oil. The system is simple to apply requiring minimal modification of current microalgae bioreactors. The use of the EhV201 to induce TAG production has been shown to be superior to current established methods of nutrient deprivation. Moreover, the technique does not require genetic modification of microalgae, avoiding regulatory challenges. Finally the technology also has added value being environmentally friendly, and possibly opening the avenue for claiming carbon credits, due to the carbon fixation of the microalgae.

+
  • Ph.D. Assaf Vardi
  • Ph.D. Assaf Vardi
1736
Biomass production by plants and other photosynthetic organisms involves carbon fixation, the process of incorporating inorganic carbon dioxide into organic compounds. Currently carbon fixation by plants and other photosynthetic organisms is the limiting factor in biomass production. Improvement in the...

Biomass production by plants and other photosynthetic organisms involves carbon fixation, the process of incorporating inorganic carbon dioxide into organic compounds. Currently carbon fixation by plants and other photosynthetic organisms is the limiting factor in biomass production.

Improvement in the metabolic pathway related to carbon fixation would have great value in increasing crop yields, synthesizing high value compounds in algae, and developing means in removing CO2 from the atmosphere to combat climate change.

The present technology is an engineered E. coli with a carbon fixation pathway. The unique innovation can be used to efficiently screen the activity of RuBisCO, the most abundant carbon fixing enzyme on earth, which is further applicable to improving biomass production in different photosynthetic organisms such as plants and algae.

Applications


·      Powerful platform for screening and improving various enzymes in the carbon fixation process.

·      Unique metabolic pathway for use in Synthetic Biology applications.

·      Possible Carbon Credits for developing improved means of carbon fixation.


Advantages


·      E. coli is fast growing and easily manipulated by various genetic tools.

·      Novel source of biomass production.

·      Potentially low cost R&D system.


Technology's Essence


The technology functions by the recombinant insertion of two enzymes from the Calvin-Benson-Bassham (CBB) into E. coli, kinase prk and the carboxylating enzyme RuBisCO. With further modifications, the engineered E. coli’s metabolism was divided into two subsections. First a carbon fixing metabolism that can incorporate inorganic CO2 into sugar production, the second subsection consumes organic pyruvate to produce energy to drive the aforementioned carbon fixing cycle. Subsequently the technology is overall carbon neutral, but is an inexpensive and fast platform for screening improvements in the CBB carbon fixation pathway.

+
  • Prof. Ron Milo
1786
Perovskites are a class of crystalline materials with a common complex chemical structure. Lead-halide hybrid organic-inorganic perovskites have recently emerged as highly efficient optoelectronic materials. Such materials are being intensively investigated and developed for photovoltaics,...

Perovskites are a class of crystalline materials with a common complex chemical structure. Lead-halide hybrid organic-inorganic perovskites have recently emerged as highly efficient optoelectronic materials. Such materials are being intensively investigated and developed for photovoltaics, photodetection, light-emitting diodes, and laser devices. Solar cells containing hybrid organic-inorganic perovskites have achieved over 20% certified efficiency.

Perovskites are most commonly synthesized by combining a metal salt (for example, a lead-based salt such as lead iodide) with an organic halide salt in a single step, by spin-coating from a solution of both salts, by co-evaporation, or by a two-step method of forming the metal salt film and subsequently exposing it to the organic halide. The existing fabrication methods suffer from high toxicity, complexity and high energy input.

We present a new method for the preparation of halide perovskites on a substrate for optoelectronic devices and solar cells, including tandem cells that produce higher voltages.

Applications


·      Solar cells

·      Other optoelectronic devices (e.g., photodetectors, light-emitting diodes, lasers)


Advantages


·      Reduced toxicity

·      Simple and straight-forward fabrication method

·      Excellent morphology control of the perovskites


Technology's Essence


Perovskites are crystalline materials with the formula ABX3, in which A and B are cations and X represents an anion. In hybrid organic–inorganic perovskites (HOIPs), A is an organic cation, B is a metal cation, and X is a halide anion.

The synthesis of HOIPs usually involves the use of toxic metal salts (for example, lead iodide or lead acetate) and organic solvents (such as dimethylformamide). Additionally, the combination of a metal salt with several organic solvents, such as dimethylsulfoxide, increases the toxicity of the solution in use.

The new fabrication method utilizes a metal or a metal alloy and an organic halide salt. In the first step, a layer comprising one of the components is deposited on a substrate. Then, the deposited layer is treated with a solution or a vapor of the second component to form a halide HOIP on a solid surface. This method provides a direct conversion of an elemental metal or a metal alloy to a halide perovskite or a perovskite related material. The main advantage of the presented method is the reduced toxicity of the solution used in the process. Additionally, the metals (mainly lead) are much less toxic in terms of manufacturing than the salts of the same metals.

+
  • Prof. David Cahen
1795
Ultra-thin endoscopes are highly desirable for many applications involving remote imaging. Current ultra-thin endoscopes are primarily video-endoscopes and have a shaft diameter of 6 mm or less. Fiberscopes, on the other hand, can reach a micro-meter diameter, thus allowing examination of small,...

Ultra-thin endoscopes are highly desirable for many applications involving remote imaging. Current ultra-thin endoscopes are primarily video-endoscopes and have a shaft diameter of 6 mm or less. Fiberscopes, on the other hand, can reach a micro-meter diameter, thus allowing examination of small, difficult-to-reach, spaces for medical and other applications. Multimode fibers are being explored as ultra-thin lensless replacements for the commonly used endoscopes. The difficulty with imaging or focusing light through a multimode fiber is phase randomization of light propagating through the fiber, which results in a complex speckle pattern at the fiber output. To overcome this obstacle, an access to both fiber ends is required for pre-calibration.

A novel endoscopic method that was developed by Prof. Silberberg at the Weizmann Institute of Science allows light focusing through a multimode fiber by approaching solely the proximal end and retrieving information about the distal end using non-linear optical feedback.

Applications


·         Clinical imaging of narrow cavities (blood vessels, respiratory system, joints, etc.)

·         Selective targeting and burning of fluorescent targets (imaging and treatment)  


Advantages


  • Ultra-thin (micro-meter scale) and flexible

  • Lensless endoscopy

  • High resolution and accuracy


Technology's Essence


We consider a two-photon lensless multimode fiber-based endoscope, where an ultrashort pulse is delivered to a fluorescently tagged sample through the fiber. The pulses excite two photon fluorescence (2PF) from a 2PF screen placed against the fiber distal end. The back-propagated 2PF that is collected by the same fiber is separated from the excitation light at the proximal end by a dichroic mirror (DM), and the Fourier-transformed image of the fiber facet is recorded by an EMCCD camera. It is then used as feedback for a wavefront-shaping optimization algorithm, controlling a spatial light modulator (SLM) at the proximal fiber end. The nature of the light propagation in the fiber allows for scanning and controlling the focus position at the fiber distal end.

+
  • Prof. Yaron Silberberg
1798
The rising demand for exclusive visual impact in many applications, along with escalating regulatory requirements drive the development of new, environmentally benign, pearlescent materials. Guanine, a common naturally mineralized material, is being used in a variety of products in industries, such as...

The rising demand for exclusive visual impact in many applications, along with escalating regulatory requirements drive the development of new, environmentally benign, pearlescent materials. Guanine, a common naturally mineralized material, is being used in a variety of products in industries, such as cosmetics, paints and jewelry due to its pearlescence effect. However, the industrial application of guanine crystals is limited since they are extracted from biological sources (mostly fish scales) with limited control over crystals dimensions, morphology and quantity for industrial applications. The main reasons impeding the use of synthetic guanine crystals are guanine insolubility in most solvents and the difficulty of obtaining crystals in the desired morphology. For these reasons, there is a thriving need for the development of a synthetic approach for the formation of well-defined anhydrous guanine crystals with tailor-made properties.

The new technology provides a novel synthetic method for the preparation of highly versatile pearlescent materials, based on guanine crystals, from aqueous solutions. The controllable size and shape of the resulting materials and the sustainability of the method make them suitable alternatives for the existing naturally occurring pearlescent pigments.

Applications


·      Cost-effective and environmentally-friendly approach

·      Control over crystals properties, including size and phase (anhydrous guanine and guanine monohydrate)

·      The same technology can be applied for the crystallization of other materials (purines and pteridines)


Advantages


·      Cosmetics and personal care products

·      Printing inks and decorative paints

·      Automotive paints.


Technology's Essence


Guanine is practically insoluble in neutral aqueous solutions. However, in aqueous acidic or basic solutions, where the molecules are ionized, guanine is much more soluble. The process involves dissolving guanine powder in either acidic or basic solutions, using HCl or NaOH, respectively, and then inducing crystallization by adjusting the pH of the solution. The crystal morphologies differ significantly when carrying out the crystallization in solutions adjusted to different pH regimes. Using pH induced crystallization, the interplay between the initial guanine concentration and the rate of pH change allow substantial control over the crystallization process and ultimately over the crystal size.

+
  • Prof. Lia Addadi
1758
For patients with AML, identification of their specific subtype and genetic background is crucial for predicting their outlook and decision of treatment. Therefore, understanding the molecular characteristics of specific subtypes of AML can lead to novel therapeutics and improve patient survival.   The...

For patients with AML, identification of their specific subtype and genetic background is crucial for predicting their outlook and decision of treatment. Therefore, understanding the molecular characteristics of specific subtypes of AML can lead to novel therapeutics and improve patient survival.  
The present invention relates to a unique vulnerability of AML subtypes, in which specific chromosome abnormalities result in the dependence of the cancer cells on the activity of native RUNX1. Selective inhibition of RUNX1 under these genetic backgrounds results in killing of the cancer cells.  Thus, the methods described in this innovation may lead to the development of novel AML therapeutics.

Applications


 


Advantages


  • Specificity – targets a signaling vulnerability which is unique to AML and does not occur in healthy cells.
  • Critical impact – the inhibition of RUNX1 in addicted cells induces irreversible killing of the cancer cells by apoptosis rather than just inhibiting their proliferation.
  • Targeting RUNX1 in the addicted AML subtypes can potentially improve patient survival and also be used as a therapy for patients which developed secondary resistance in response to conventional chemotherapy.   

Technology's Essence


The RUNX1 transcription factor is a frequent target of various chromosomal translocations.
The t(8;21) and inv(16) AML subtypes create oncoproteins which interfere with RUNX1 activity in a dominant-negative manner.
While RUNX1 is frequently inactivated in other forms of AML, an active RUNX1 allele is maintained in both t(8;21) and inv(16) AML patients, underscoring the medical significance of native RUNX1 in A-E and C-S mediated leukemogenesis.
Knockdown (KD) of RUNX1 in cell culture models for A-E and C-S showed that these cells are physiologically dependent on RUNX1 activity for their survival and inhibition of RUNX1 in these cells leads to apoptotic cell death. This apoptosis is triggered by decreased expression of key mitosis-regulatory gene.
Therefore, AML subtypes associated with an altered RUNX1 activity or expression are addicted to native RUNX1 for their survival.  Targeting RUNX1 in these patients is expected to activate apoptosis and compromise leukemogenesis.
Thus, the genetic addiction described in the current innovation can be used for the development of novel targeted therapies for AML.

 

+
  • Prof. Yoram Groner
1676
A novel renewable energy method for storage of concentrated solar power (CSP) thermal energy directly to electrochemical energy that can be used for for distribution.A crucial issue for CSP technologies today is providing energy capable of dispatchable generation, that is, sources of electricity whose...

A novel renewable energy method for storage of concentrated solar power (CSP) thermal energy directly to electrochemical energy that can be used for for distribution.
A crucial issue for CSP technologies today is providing energy capable of dispatchable generation, that is, sources of electricity whose power load can be changed instantaneously with power demand. Further commercial deployment of CSP on a large scale depends on increase of the annual contribution of solar electricity, better coping with the intermittent nature of this resource and rapid integration with existing electrical distribution infrastructure, i.e. smart grids. 
The technology presented here offers a unique solution to these problems while significantly reducing monetary and environmental costs associated with current CSP systems.
Unlike conventional thermal CSP plants, the novel method does not require the use of a turbine to convert heat to electricity, and the electricity is directly obtained from the electrochemical cell during its discharge cycle. Moreover, this energy storage technique precludes the use of electric power generators (e.g. turbines, wind turbines, photovoltaic panels) which are often used to recharge electrochemical cells by applying electrical power to the cells' electrode terminals. This reduces expenses and eliminates inefficiencies of a traditional solar electrical plant.

Applications


  • As modular stand-alone electrical plant for commercial or private use.
  • Integrate into existing power plants for load sharing.

Advantages


  • Directly transform solar thermal energy into electrical potential energy.
  • Transport of large amounts of water in arid areas is not required.
  • Battery can change loading instantaneously for:
    - Use in smart grid and dispatchable generation
    - Easily Incorporated with other green energy solutions

Technology's Essence


This novel system utilizes a rechargeable thermochemical cycle based on Na-S battery technology. The innovation is the exploitation of concentrated solar radiation for thermo-chemical charging instead of electricity from photovoltaic or wind resources as done today. With this concept, a final efficiency of about 50% from solar to electricity can be achieved, which makes a monumental economic impact on existing CSP technologies. The sodium-sulfur battery discharge cycle usually works at temperatures ranging between 300 and 350oC, at which the sodium, sulfur and the reaction product of sodium polysulfide, Na2Sx (where x=3 to 5), exist in their liquid state. Charging of the battery is achieved at temperatures of 1500-1700 oC, when sodium polysulfide is fully decomposed and the full electrical potential of the battery is restored.[1] Instead of charging the Na-S Battery with an external source of electricity to decompose the sodium polysulfide compound back to its Na and S ingredients, it is proposed that the decomposition process will be achieved thermally via CSP.

+
  • Mr. Michael Epstein
1733
The spatial distribution of proteins inside the cell is under tight regulation. This regulation is necessary to ensure proper functioning of the cell, and is of particular importance when extracellular stimulation is applied. Upon stimulation, many signaling proteins rapidly and dynamically change...

The spatial distribution of proteins inside the cell is under tight regulation. This regulation is necessary to ensure proper functioning of the cell, and is of particular importance when extracellular stimulation is applied. Upon stimulation, many signaling proteins rapidly and dynamically change their location. Today, there is a widely recognized need to identify novel sequences which regulates nuclear translocation.
Recently, Prof. Zeger and his team discovered a new level of regulation to stimulated transcription. They showed that ?-like importunes are central mediators of nuclear translocation of signaling proteins. Furthermore they identified the site of interaction and designed accordingly a peptide which was found to prevent nuclear translocation.
This technology presents peptides with the potential of treating inflammatory and immune disease by regulating (prevent or promote) the translocation of proteins into the nucleus.

Applications


  • Inflammation
  • Immune diseases

Advantages


  • Effective
  • Safe

Technology's Essence


The researchers found that ?-like importins play a key role in JNK and p38 translocation. They also found that the translocation of these MAPKs is mediated by the formation of either Imp3/Imp7/MAPK or Imp3/Imp9MAPK heterodimers. Most importantly, the researchers identified the site in p38 that mediate the interaction with Imp7 and Imp9 and showed that the important sequence lies within residues 20-30 of p38?. Subsequently they synthesized a 14 amino acid myristoylated peptide based on the sequence of residues 21-34 of p38?. When it was applied to HeLa cells prior to stimulation, it prevented the nuclear translocation and Imp7/9 interaction of the MAPKs. Since the peptides of this technology are able to specifically inhibit the nuclear activities of p38 (such as inflammatory activities) without modulating their cytoplasmic activities, these peptides may serve as a therapeutic agent for inflammatory and apoptosis related diseases without having side effect.

 

+
  • Prof. Rony Seger
1712
  • Prof. Yechiel Shai
1772
MTCH2 as a novel target for the treatment of obesity.Obesity is an escalating public health problem with an increasing prevalence worldwide, and a primary contingency of many life-threatening diseases, as well as early mortality. In the U.S. alone, more than one-third of adults are obese. Obesity-...

MTCH2 as a novel target for the treatment of obesity.
Obesity is an escalating public health problem with an increasing prevalence worldwide, and a primary contingency of many life-threatening diseases, as well as early mortality. In the U.S. alone, more than one-third of adults are obese. Obesity-related conditions include heart disease, stroke, type 2 diabetes and certain types of cancer, some of the leading causes of preventable death. Physicians and patients alike consider the weight-loss efficacy of the current therapeutics to be unsatisfactory. Therefore, there is an unmet need for innovative options that are at once safe and efficacious, and allow the patient to maintain weight loss.
The present invention describes the identification of Mitochondrial Carrier Homolog 2 (MTCH2) as a novel player in muscle metabolism and the therapeutic potential of inhibiting MTCH2 for the treatment of diet-induced obesity and diabetes.

Advantages


  • A fresh approach for targeting weight-related disorders
  • Direct effect on metabolism instead of indirect mechanisms of current therapeutics which target appetite modulation.
  • Protection from diet-induced obesity can be used as a prevention treatment for people with a tendency for weight gain.  

Technology's Essence


MTCH2 functions as a receptor-like protein for the pro-apoptotic BID protein in the mitochondria.
MTCH2 was identified as one of six new gene loci associated with Body Mass Index (BMI) and obesity in humans suggesting that MTCH2 may also play a role in metabolism.
MTCH2 was recently shown by the Gross’s lab to also function as a repressor of   mitochondria oxidative phosphorylation (OXPHOS) in the hematopoietic system.
Deletion of MTCH2 in skeletal muscle increases mitochondrial OXPHOS and mass, and increases capacity for endurance exercise. In addition, loss of MTCH2 increases mitochondria and glycolytic flux in muscles as measured by monitoring pyruvate and lactate levels.
MTCH2 knockout mice are protected from diet-induced obesity, hyperinsulinemia, and are more prone to weight loss upon caloric restriction.
Therefore, the association of MTCH2 with mitochondrial function offers a potential novel target for muscle metabolism modulation in the fight against metabolic disorders such as obesity and diabetes.

 

+
1684
Gaseous energy sources such as hydrogen and natural gas (predominantly methane) encompass an intrinsic transport problem because of their volatility and flammability. Adsorption of the gas on a solid material (such as MOF) facilitates safe, light and economical transport of the gas. This is especially...

Gaseous energy sources such as hydrogen and natural gas (predominantly methane) encompass an intrinsic transport problem because of their volatility and flammability. Adsorption of the gas on a solid material (such as MOF) facilitates safe, light and economical transport of the gas. This is especially significant in the huge natural gas (NG) market where solutions are required for storage and transport of the gas whether from NG reservoirs in high pressure giant tanks or as a compact low pressure NG tank for small vehicles and other NG powered devices.
The invention involves a new method for the formation of uniform metal organic frameworks (MOFs) at quantitative yields and in a controlled manner.
These MOFs can be tailored to adsorb specific gases for low pressure - high volume storage and transport applications.

Applications


  • Low pressure – high volume gas storage and transportation
  • Safe storage of toxic or otherwise dangerous gases
  • Low energy solid phase gas separation and purification
  • Production of MOF-based catalysts

Advantages


  • Uniform crystallite morphology
  • A quantitative process
  • Ability to design and control product structure
  • Control of pore size
  • Single step process
  • No additives

Technology's Essence


The invention comprises a new solvothermal synthetic procedure in which specific metal ions are selected to react with specific organic ligands to form uniform sub-microstructured MOFs with a narrow size distribution and without the need for a modulator to define the crystal morphology.
Controlling the selected reagents as well as the specific reaction conditions influences the resulting crystallites formed and enables a fine selection of the desired structure.
MOFs prepared this way have exceptional uniformity profiles of size and shape and can be tailored to selectively adsorb specific gases for low pressure - high volume storage and transport applications.

+
  • Prof. Milko E. Van der Boom
1749
Our novel technology provides an inexpensive, safe and clean solution for loading and unloading of hydrogen on demand with high potential hydrogen storage capacity. Hydrogen storage is currently the key hurdle to its utilization as an alternative green fuel. Being the smallest molecule, hydrogen is...

Our novel technology provides an inexpensive, safe and clean solution for loading and unloading of hydrogen on demand with high potential hydrogen storage capacity.
Hydrogen storage is currently the key hurdle to its utilization as an alternative green fuel. Being the smallest molecule, hydrogen is highly diffusive and buoyant. Currently, hydrogen is stored physically as a gas, requiring high-pressure tanks, or in liquid form at cryogenic temperatures, both methods require high energy input. Proposed chemical storage systems are based on relatively expensive materials, suffer from poor regeneration after hydrogen release and require elevated temperatures and pressures.
The presented technology utilizes inexpensive and abundant organic compounds that generate hydrogen gas during a chemical transformation. Hydrogen release and the regeneration of the original compound are performed in mild conditions using the same catalyst. This system is a promising candidate to be the basis of compact and cost-effective chemical hydrogen storage platforms.

Applications


  • High potential hydrogen storage capacity (6.6 wt%)
  • Inexpensive and readily available hydrogen carriers (aminoalcohols)
  • Relatively mild release and regeneration conditions

  • Advantages


    • Hydrogen-fueled systems, including fuel cells
    • High capacity hydrogen storage systems

    Technology's Essence


    The technology is based on aminoalcohols that are catalytically converted to cyclic dipeptides, while forming hydrogen gas, using a ruthenium pincer catalyst. Peptide hydrogenation, using the same catalyst, regenerates the aminoalcohol. The same method can be applied with diaminoalkanes and alcohols as well.
    The reaction requires a relatively low organic solvent volume, a catalytic amount of base (KOtBu) for the in situ generation of the active catalyst and mild reaction conditions in terms of hydrogen pressure (50 bar) and temperature (~100 oC). Repetitive cycles of the dehydrogenation-hydrogenation reactions can be performed without adding new catalyst, while maintaining high percentages of aminoalcohol conversion.

    +
    • Prof. David Milstein
    1716
    An efficient and selective decomposition of plant biomass carbohydrates to their basic components, carbon monoxide and hydrogen, for use as syngas.Terrestrial plants contain about 70% hemicellulose and cellulose, which constitute a significant renewable bio-resource with potential as an alternative to...

    An efficient and selective decomposition of plant biomass carbohydrates to their basic components, carbon monoxide and hydrogen, for use as syngas.
    Terrestrial plants contain about 70% hemicellulose and cellulose, which constitute a significant renewable bio-resource with potential as an alternative to petroleum feedstock for carbon-based fuels. Traditional conversion of biomass to liquid fuels has been in the form of ethanol and bio-diesel, but this process is inefficient and much of the starting material is unusable and ultimately becomes waste.[1] Additionally, use of ethanol or bio-diesel is not universal to all engines as vehicles require specialized components to run on these fuels.
    The presented technology allows for significantly greater efficiency in use of starting material, and the versatile final product of syngas, which can be a fuel itself or used as a fuel precursor in the well-known Fischer-Tropsch process to create hydrocarbons.[2] Alternatively, in a hydrogen economy scenario, this method can also be used to convert carbon monoxide to hydrogen via the water-gas shift reaction. Advantageously, both processes allow for the polyoxometalate (POM) catalyst to be reused without the need for recovery, which enables continuous use in a refinery setting.

    Applications


    • Liquid hydrocarbon fuel synthesis from syngas
    • Entry into a new market – hydrogen production from biomass

    Advantages


    • Efficient and complete breakdown of starting biomass material
    • Possible to produce hydrogen or syngas as product

    Technology's Essence


    The technology allows for preparation of syngas by reaction of a carbohydrate with a POM catalyst in the presence of a concentrated acid under anaerobic conditions, to yield carbon monoxide, followed by electrochemical release of hydrogen. This two-step process allows for easy separation and storage of the desired products. An alternative application of the same POM catalyst relates to a method for preparing formic acid in a similar method, but in a solvent consisting of a mixture of alcohol and water.
    This reaction is based on the unexpected finding that POM catalysts, such as H5PV2Mo10O40, catalyze plant biomass derived polysaccharides of general form (CnH2nOn)m, with high selectivity and efficiency under mild conditions. Formation of CO occurs through an intermediate formation of formic acid and formaldehyde, and transformation of these transition compounds in concentrated acid results in the desired CO product. During this process, hydrogen atoms are stored on the POM catalysts as protons and electrons. Hydrogen gas is subsequently electrochemically released from the POM catalyst, which returns the catalyst to its original oxidized state and allows for continued reuse.

    +
    • Prof. Ronny Neumann

    Pages