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Avaliable Technologies

Category
Technology Name
Briefcase
Scientist
1906
Nanowires are being produced and integrated into various systems today, including solar cells, nano-sensors, nano-electrodes, transparent touch-screen coatings, and LED replacements. Thus far, several challenges have hindered the commercial advancement of nanowire-based technologies. Two major setbacks...

Nanowires are being produced and integrated into various systems today, including solar cells, nano-sensors, nano-electrodes, transparent touch-screen coatings, and LED replacements. Thus far, several challenges have hindered the commercial advancement of nanowire-based technologies. Two major setbacks have been: (1) the lack of compatibility with existing platforms, mostly silicon technology and (2) low cell voltage, due to an in-parallel rather than in-series nanowire array integration, limiting the open-circuit voltage to less than 1 V whereas the voltage necessary to power certain devices can be several volts and up. Researchers from the Weizmann Institute of Science have demonstrated a unique method that can solve these problems. The new technology is silicon-compatible and allows in-series nanowire integration, resulting in high voltage cells on a reduced size chip, thus expanding the application opportunities for nanowire photovoltaic technologies, such as light harvesting and autonomous powering of IoT components.

Applications


PV cells and photodetectors for:

·         Light harvesting/light sensing systems for IoT related systems  

·         BIPV (Building Integrated Photovoltaics) applications including smart windows

·         Transparent coating for touch screens/LED replacements

·         High-density data storage devices.


Advantages


A silicon-based integrated technology for high voltage photovoltaic generation:  

·         Increased and easily scaled-up voltage on the same chip using an in-series nanowire integration

·         Can be applied via existing production technologies (e.g. lithography in silicon wafers) and be integrated into existing systems, including CMOS and MEMS based products.


Technology's Essence


The research focused on two areas; (1) novel generic methods for nanowire growth via nanolithography and (2) production of in-series photovoltaic cells from core-shell nanowire arrays.

Guided growth of planar nanowire arrays with custom-designed shapes on amorphous substrates was achieved by fabricating trenches via nanolithography in two novel configurations that were found to be useful for nanowire guided growth by artificial epitaxy. The precise dimensions of the trenches as well as the growth parameters can be optimized for each material to improve the yield and morphology.

For the production of planar in series nanowire-based photovoltaic cells, CdS-Cu2S core-shell arrays on insulating substrate were produced by the combination of vapor-phase surface-guided horizontal growth and solution-proceeded cation exchange reaction. Consequently, the researchers were able to demonstrate an easy to scale-up, straightforward implementation method for fabrication of photovoltaic cells based on core-shell nanostructures. They additionally presented the facile monolithic integration of microscale cell photovoltaic modules with parallel or series configuration based on these core-shell arrays. An open-circuit voltage, up to 2.5 V was obtained from a tandem module, with 4 unit cells connected in series with a potential for an even larger number of in-series unit integration. The presented modules are promising autonomous power sources for next-generation integrated nano-systems and autonomous wireless-electronics.

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  • Prof. Ernesto Joselevich
1840
Searchable symmetric encryption with practical big-data performance and strong security Highlights Outsourcing data storage to remote servers offers invaluable benefits while introducing many concerns when dealing with sensitive data. In the presence of potentially-vulnerable servers, strong user-side...

Searchable symmetric encryption with practical big-data performance and strong security

Highlights

Outsourcing data storage to remote servers offers invaluable benefits while introducing many concerns when dealing with sensitive data. In the presence of potentially-vulnerable servers, strong user-side encryption preserves the confidentiality of the data but renders essential operations (such as keyword search) extremely expensive and sometimes even unfeasible. To overcome this problem, the cryptography and security community has developed various searchable symmetric encryption (SSE) methods that enable searching through encrypted data without revealing any unnecessary information. However, despite the rapidly increasing commercial interest in SSE technology, it has been shown that the performance of the existing methods scales badly to big data, not due to their usage of expressive cryptographic tools, but rather due to their poor data locality. Practical big-data performance and strong security are the two most essential ingredients for unleashing the potential of SSE technology, but have so far emerged as two extremely conflicting goals.

Our Innovation

The first searchable symmetric encryption (SSE) method that offers practical big-data performance while guaranteeing strong security. The method can be based on any off-the- shelf block cipher and enjoys essentially optimal space and communication overheads together with near-optimal data locality.

 

Key Features

·         A breakthrough combination of cryptographic and algorithmic techniques

·         Significant improvements over previous SSE systems in both security and performance

·         Practical big-data performance

·         Strong and precise security guarantees

·         Low-cost implementation given any off-the- shelf block cipher

Development Milestones

·         Research complete and technology ready for commercialization

The Opportunity

·         Market research firm ‘Markets and Markets’ projects that the global Cloud security market will grow from $4.20 billion in 2014 to $8.71 billion in 2019, representing an estimated compound annual growth rate (CAGR) of 15.7% from 2014 to 2019.

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  • Prof. Moni Naor
1892
Phenol is an important industrial commodity used as a precursor to many useful compounds. It is being utilized in huge amounts in a wide range of industry sectors including the pharmaceuticals, plastic-related-products production, paints & coatings, electrical equipment, foams and fuel additives....

Phenol is an important industrial commodity used as a precursor to many useful compounds. It is being utilized in huge amounts in a wide range of industry sectors including the pharmaceuticals, plastic-related-products production, paints & coatings, electrical equipment, foams and fuel additives. The global phenol market is predicted to witness a robust CAGR of 6.8% during the period of 2018-2022 reaching a volume of 14 Million Tons by the end of the forecasted period, which will account for $17 bn in value.

The current most prevalent method for phenol production is the three-step cumene hydroperoxide process that while established, has serious drawbacks related to safety, low selectivity in the formation of cumene hydroperoxide, low per pass yield and the formation of acetone as a byproduct. A new phenol production method, developed at the Weizmann Institute of Science based on electrocatalytic oxidation of benzene, allows for a simple, efficient, cost-effective and selective production of phenol. This new method can result in a drastic cost reduction that will further be emphasized in the future with the ongoing reduced need of the current process’ byproduct – acetone (CAGR of approximately 3.6% during the period of 2018-2023, a significantly lower growth rate in comparison to phenol). The method suggested here can also be applied in the future in other processes for conversion of arenes to the corresponding phenols. 

Applications


Main process:

•                     Production of phenol from benzene

The technology can potentially be applied for additional chemical processes:

•                     Production of acetaldehyde from ethylene

•                     Production of malonic and/or pyruvic acids from acrylic acid

•                     Production of various alcohols from aliphatic and aromatic hydrocarbons.


Advantages


A simple, fast and cost-effective process:

•                     Direct and Highly selective (no acetone as a co-product)

•                     Low temperature process

•                     Safe Process, no hazardous by-products.


Technology's Essence


An electrocatalytic transformation using formic acid to oxidize benzene and its halogenated derivatives to selectively yield aryl formates that are easily hydrolyzed by water yielding the corresponding phenols. The formylation reaction occurs on a Pt anode in the presence of [Co(III)W12O40]and similar anions as catalyst and Li formate as electrolyte via formation of a formyloxyl radical as the reactive species, which was trapped by a BMPO spin trap and identified by EPR. Hydrogen was formed at the Pt cathode. The sum transformation is ArH + H2O ® ArOH + H2. Non-optimized reaction conditions showed a Faradaic efficiency of 75-80 % and selective formation of the mono-oxidized phenol product in a 35 % yield. Decomposition of formic acid to CO2 and H2 is the side-reaction.

Published in: Angew. Chem. Int. Ed.2018, 57, No. 19, 5403-5407  

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  • Prof. Ronny Neumann
1827
New 19Fluoride based nanocrystals (19FNCs) developed at the Weizmann Institute present high solubility and can be injected into the body’s soft tissues for high quality and target specific MRI. This new generation MRI agents are safe with high clearance capabilities, and can allow superior image...

New 19Fluoride based nanocrystals (19FNCs) developed at the Weizmann Institute present high solubility and can be injected into the body’s soft tissues for high quality and target specific MRI. This new generation MRI agents are safe with high clearance capabilities, and can allow superior image quality. Owing to their unique performance, these new MRI agents can have a profound impact on the MRI field, as they can be utilized in specific MRI diagnostic tools for a variety of pathologies.

Many of the currently available contrast agents are not specific enough and are therefore not suitable for a variety of advanced applications such as therapeutic monitoring platforms and   pathology diagnostic tools. Furthermore, recent discoveries of the potential toxicity of Gadolinium, the most prominent contrast agent for MRI, are stressing the need to diversify the variety of materials in use. Applying the new 19FNC imaging agent as a specific marker for MRI may help solving some of these problems. Furthermore, this new technology may result in a significant impact on the medical diagnostic field, including the monitoring and diagnostic of the onset and progression of diseases such as Alzheimer’s, Parkinson’s, multiple sclerosis and even cancer.  

Water-soluble PEGylated CaF2 nanocrystals. a) Illustration of the PEGylated CaF2 nanocrystals (CFP). b) DLS histograms showing the nanocrystals’ monodispersity. c) High-resolution F NMR spectrum in aqueous solution.

 

Applications


Various applications in the medical imaging and diagnostics fields:

·         Improvement of existing MRI quality

·         Monitoring multiple targets simultaneously

·         Applying MRI for specific applications:

o   Monitoring therapeutic cells with MRI

o   Mapping inflammation (associated with many diseases)

o   Accurate diagnostic tool for various pathologies achieved through specific surface modifications

o   Tracking therapeutic cells and report on their therapeutic capabilities

·         Material science NMR applications


Advantages


Fluoride nanocrystals with high NMR sensitivity, that are safe and soluble:  

·         Enable high quality images, with no background signal

·         Can be combined with other contrast agents for a more detailed image

·         Safe - non-toxic with high body clearance capabilities

·         High solubility and surface modifiability - owing to the nanocrystals’ unique coating

·         Allow artificial “multicolor” MRI for multiplexed imaging.

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  • Ph.D. Amnon Bar-Shir
1845
A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices. The optical metasurfaces that we develop are composed of closely spaced optical nanoantennas...

A new technology for producing flat optical components based on optical metasurfaces. 
These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices. The optical metasurfaces that we develop are composed of closely spaced optical nanoantennas which can be deposited on a wide variety of rigid and flexible surfaces. The engineered nanoantennas allow capturing and directing light at specific colors and polarizations and by that create surfaces with engineered and ‘unnatural’ optical functionality. The active area of the component can be ultrathin allowing in addition to the unique optical properties to reduce the size of the optical components.

Moreover, functionality can be enhanced by creating multilayered components.

Applications


The proposed technology can be used to generate a wide variety of novel diffractive optical elements including flat lenses with multispectral and polarization dependent functionality, multifocal components, beam shapers etc. So far we have demonstrated in the lab the use of this technology to correct chromatic aberrations from a diffractive lens and to generate multifunctional laser beam shapers.


Figure 1(a) shows the calculated chromatic aberrations of the focal point using a conventional Fresenel Zone Plate (FZP) and figure 1(b) shows simulation results of focusing light at wavelength of 620 nm and wavelength of 450 nm through a conventional FZP which was designed to focus the light at 620nm to 1mm. It can be seen that light at 450nm is focused further away to ~1.4 mm. The same problem will occur when imaging through such a lens – only one of the wavelengths will be in focus at the image plane. Figure 1(c) shows the simulation results of the focusing properties of a metamaterials based FZP (Meta-FZP). The two wavelengths share the same position of the focal spot which means that chromatic aberrations are corrected. We can use the same technology to correct more than two wavelengths. Fig. 1(d) illustrates this concept.
Figure 1(e) shows a preliminary prototype of a metamaterial based lens that was designed and fabricated at Tel Aviv University nano-center. Fig. 1(f) shows the ability of the meta-FZP to focus blue and yellow light to the same spot by that correcting the chromatic abberations. This shows the first demonstration to our knowledge of chromatic abberation correction by metasurfaces.
In addition to chromatic abberation corrections we demonstrate that this technology can be used for multifunctional laser beam shaping. Fig. 1(g)-(j) present experimental results present experimental results for multifuntional beam shapers which are based on metasurfaces.
The technology can be enhanced also for multispectral manipulation and analysis.

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1903
THE INNOVATION:   A non-chromatographic antibody purification method not relying on Protein A nor any ligand, had been developed. Highly pure (>95%) human, mouse, rabbit or sheep IgG's are obtained in good yields within 20-30 minutes. The technology addresses a projected $440M antibody purification...

THE INNOVATION:

 

A non-chromatographic antibody purification method not relying on Protein A nor any ligand, had been developed. Highly pure (>95%) human, mouse, rabbit or sheep IgG's are obtained in good yields within 20-30 minutes. The technology addresses a projected $440M antibody purification reagents market.

 

MARKET OPPORTUNITY:

 

The past two decades have evidenced a strong focus on monoclonal antibody (mAb) therapeutics. Today, there are already 50 antibody-based drugs on the market; more than 550 are at various stages of development; and the competition among the large biopharmaceutical companies is aggressive. The global market for mAb therapeutics in 2014 reached USD 80.3 billion. The global mAb market is expected to rise at a compound annual growth rate (CAGR) of 8.1% to nearly USD 128 billion by 2020. The development of these new molecular agents, successfully directed to specific cellular targets, is playing a crucial role in the pharmaceutical industry. This trend shows the strong focus of top biopharmaceutical companies on biologics, including mAb therapeutics (Frost & Sullivan 2015).

 

Accordingly, the rapid growth of the mAb market is driving pharmaceutical firms to find avenues that will reduce production costs. Purification of mAb's, is still a major contributor (50-80%) of manufacturing costs, particularly due to the use of Protein A columns. Whereas Protein A is the most efficient, specific and common ligand used by all biopharmaceutical companies, it is also highly expensive. It is estimated that removal of the Protein A step would cut 40% in the total production costs of mAb's and this is exactly what our technology is aiming at. 

 

THECHNOLOGY:

 

The technology relies on unique detergent scaffolds onto which IgG's bind almost quantitatively, whereas the vast majority of non-IgG proteins are rejected. Bound IgG's are recovered from the detergent scaffolds in great purity (>95%) while leaving residual impurities behind. IgG purification was demonstrated in serum-free media containing BSA\HSA. The fact that, purified IgG's preserve their binding specificity, implies that, the presented method may provide a cost-effective viable alternative to: Protein A chromatography 

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  • Prof. Mordechai Sheves
1839
Numerous medical conditions are related to inflammation, such as pancreatitis, psoriasis, inflammatory bowel disease, atherosclerosis, neurodegeneration, and more. However, determination of inflammation in the body, especially at early stages of a pathology is difficult to assess. Therefore, there is a...

Numerous medical conditions are related to inflammation, such as pancreatitis, psoriasis, inflammatory bowel disease, atherosclerosis, neurodegeneration, and more. However, determination of inflammation in the body, especially at early stages of a pathology is difficult to assess. Therefore, there is a great clinical need for diagnostic tools to gauge inflammation.

The team of Prof. David Wallach have discovered novel biomarkers in exosomes related to necroptosis, a form of programmed cell death that induces inflammation. Using these biomarkers in exosomes different diagnostic tests can be developed for an array of inflammatory conditions.  

Applications


?  Diagnostics for inflammation

?  Specificity in terms of tissue affected when combined with other biomarkers


Technology's Essence


Cell-derived vesicles termed exosomes are commonly found in bodily fluids such as blood and urine. Consequently, by examining these exosomes it is feasible to discover different biomarkers for the state of health in the human body. The Wallach team discovered that when the kinase RIPK3 is activated, a known inducer of inflammation and necroptosis, it also phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) as one of its targets. Phosphorylated MLKL was then shown to increase exosome production, which led to a greater release of phosphorylated MLKL in said exosomes. Therefore using in vitro work the Wallach team was able to show that screening exosomes for phosphorylated MLKL represents a potential diagnostic for inflammation.  

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  • Prof. David Wallach
1848
Single-cell RNA sequencing (RNA-Seq) is a powerful tool to identify and characterize the transcriptome of single cells. While providing unprecedented resolution in terms of studying cells, single-cell RNA-Seq is functionally a descriptive tool, unless combined with gene manipulation. CRISPR-Cas9 is a...

Single-cell RNA sequencing (RNA-Seq) is a powerful tool to identify and characterize the transcriptome of single cells. While providing unprecedented resolution in terms of studying cells, single-cell RNA-Seq is functionally a descriptive tool, unless combined with gene manipulation. CRISPR-Cas9 is a genome-editing technology that enables mutating specific and known targets in the genome by using guide RNAs that match the desired target site. CRISPR can therefore be used to generate single gene knock-outs and to create pooled screens that connect genes to functions. However, single-cell RNA-Seq is not scalable, and CRISPR lacks the resolution to elucidate complex phenotypes.

The research team of Prof. Amit developed a new method which combines the two aforementioned techniques – CRISP-Seq. The method uses the ability of CRISPR-Cas9 to induce site-specific mutations and the power of single-cell RNA-Seq to study gene expression in high resolution. Together they enable to examine gene circuits, pathways and functions affected by interference with numerous genes in a single experiment.

Applications


* Enables both manipulation and study of cells

* High resolution of single-cell gene alterations

* High-throughput data on multiple genes from one experiment


Technology's Essence


CRISP-Seq protocol functions by inducing mutations for one or more target genes, on the single cell level using the CRISPR technology. The vectors used for mutation are barcoded for detection and tracking by RNA-Seq, as well as include probes (e.g. fluorescence) for a visible phenotype that can be used for sorting in flow cytometry. Single-cell RNA-Seq completes the process where the effects on the transcriptome of single or multiple mutations can be examined in high-throughput single cell level.

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  • Prof. Ido Amit
1868
The treatment of respiratory conditions is currently one of the major challenges to health care systems all over the world. The problem is that most therapeutics currently available for treating pulmonary indications are non-curative, and simply improve symptoms. Presently the only cure for late stage...

The treatment of respiratory conditions is currently one of the major challenges to health care systems all over the world. The problem is that most therapeutics currently available for treating pulmonary indications are non-curative, and simply improve symptoms. Presently the only cure for late stage pulmonary diseases is a lung transplant, which includes its own host of problems ranging long waitlists to lifelong immunosuppression. These issues explain why pulmonary diseases represent the second leading cause of death in the world. Therefore, a strong need exists for alternative therapeutic options in treating pulmonary related diseases.

Prof. Yair Reisner and his research group have developed a unique set of methods for culturing and transplanting cells for use in treating respiratory illnesses. Their innovation was not simply an improvement in terms of symptoms but actually showed effective lung repair in mouse models. 

Applications


?  Treatment of lung indications

?  Protocol developed such that the method is compatible with donor (allogeneic) cells


Technology's Essence


The Reisner research group has developed two methods for cell transplantation to repair pulmonary diseases. The first method involves incubating a suspension of fetal pulmonary tissue that is developed to a gestation period of about 20-22 weeks. The reason being is that this acts as the optimal gestation window, where the cells show the high amount of different types of pulmonary progenitor cells. When transplanted into lung damaged mouse models, the cells differentiated and incorporated themselves into the lung, forming fully functional units.

The second method involves sourcing a specific hematopoietic stem cell population from fetal lung. Following a thorough understanding of the therapeutic potential of the cells, in their capacity to develop into the desired lineages. The Reisner group developed a protocol in which the transplantation of allogeneic cells was feasible but did not require long-term immunosuppression. Such that the mouse models showed an ability to develop immunotolerance to said donor cells, and achieved lung repair.

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  • Prof. Yair Reisner
1805
Obesity is the health epidemic of the modern world, with nearly half the global adult population being categorized as obese. The consequences of said mass obesity is that it is overwhelming the medical systems all over the world, as obesity is linked to numerous diseases ranging from diabetes to cancer...

Obesity is the health epidemic of the modern world, with nearly half the global adult population being categorized as obese. The consequences of said mass obesity is that it is overwhelming the medical systems all over the world, as obesity is linked to numerous diseases ranging from diabetes to cancer. The challenge is not only in reducing obesity through weight loss programs, be it via dietary programs, bariatric surgery, and so on. The issue is in ensuring that the weight loss remains, as nearly 80% of those with successful initial weight loss, relapse to their previous obese state or worse. Consequently, there is a fundamental need to treat individuals to ensure that reduction of weight is maintained.

The collaborative efforts of Prof. Eran Segal and Prof. Eran Elinav have led to an innovation by understanding the gut microbiome. Whereby understanding the microbial population of the intestinal tract can be used to diagnose for future obesity relapse and possible bacterial populations and/or chemical agents that can assist in stopping weight gain.

Applications


  •   Diagnostic to test which populations are more susceptible to relapsed obesity

  •   A method of either using an agent or a specific bacterial population to reduce relapsed obesity


Technology's Essence


The research teams of Profs. Segal and Elinav investigated the role of the gut microbiome in obesity relapse. Using mouse models where they cycle between weight loss and weight gain, it was noted that gut microbial populations were altered after weight gain. Even after cycling to weight loss, said mice retained a microbial “memory”, such that specific populations of bacteria were indicative of weight re-gain. By using said bacterial populations, it is possible to diagnose and determine whom is most susceptible to relapsing obesity even after weight loss programs. Additionally, they discovered that maintaining or boosting certain bacterial populations can act as a method to ameliorate obesity relapse.

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  • Prof. Eran Segal
1825
Senescence is a form of cell-cycle arrest which occurs in many cell types. Cellular senescence can reduce tissue damage and tumorigenesis; however long-term induction of senescence promotes fibrosis, metastasis, inflammation, tissue damage and tissue aging. Senescent cells are known to be involved in...

Senescence is a form of cell-cycle arrest which occurs in many cell types. Cellular senescence can reduce tissue damage and tumorigenesis; however long-term induction of senescence promotes fibrosis, metastasis, inflammation, tissue damage and tissue aging. Senescent cells are known to be involved in many disorders and pathologies – from cancer to hair loss. Identification and elimination of senescent cells may thus be beneficial for a variety of diseases.

Prof. Krizhanovsky and his team performed clever proteomic studies and discovered surface markers that are unique to senescent cells of the fibrotic tissue. These cell surface markers which differentiate senescent cells from non-senescent cells can be utilized for antibody mediated elimination of these cells, with the goal of treating fibrotic disease.

 

Applications


* Novel cell surface markers of senescent cells

* Treat senescence-related diseases

 


Advantages


Prof. Krizhanovsky's team induced senescence in vitro by DNA damage (DIS) or oncogenes (OIS) and explored proteins expressed on these senescent cells by mass spectrometry. Then a panel of cell-surface proteins which identified the senescent cells was assembled and verified in vivo. Among these proteins, protein "X" was further studied and found to be senescent-cell specific. The group currently attempts to determine its biological role and develop a targeting antibody to protein “X”.

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  • Prof. Valery Krizhanovsky
1843
Analysis of the transcriptome of cells can inform greatly about the state of said cells, including maturation, activation, transformation, etc. Therefore it would be of great research and clinical value to analyze transcriptomes of different cell populations and to compare gene expression on large...

Analysis of the transcriptome of cells can inform greatly about the state of said cells, including maturation, activation, transformation, etc. Therefore it would be of great research and clinical value to analyze transcriptomes of different cell populations and to compare gene expression on large scales. A particularly useful method would be Next Generation Sequencing (NGS) as it allows parallel sequencing in high sensitivity, reducing cost and time. However, NGS requires special protocols and preparation procedures in order to ensure a high quality and unbiased analysis.

The lab of Prof. Amit has developed a high-throughput system using tools, techniques, and kits for analyzing transcriptomes by NGS for analysis of gene expression. From the initial stage of cell preparation all the way to library generation, those innovative methods contribute to the power of NGS and provide effective tools to study cellular processes with a high-quality output.

Applications


* Novel method

* Multiple applications whether comparing cell states or different pathologies

* Unbiased analysis of different cell types


Technology's Essence


Prof. Amit and his lab members developed an automated framework which enables sequencing transcriptomes of single cells or cell populations. This framework includes the extraction of RNA from the isolated cells, RNA fragmentation, and cDNA production. Ultimately, libraries are created which include various additions such as barcodes and adapters and can be sequenced to provide comprehensive insight on gene expression within the cells.    

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  • Prof. Ido Amit
1858
Jet lag is a ubiquitous problem for air travelers. As the process of rapidly shifting time zones leads to the body’s circadian rhythm being out of sync to the destination’s time schedule. This has a variety of impacts on the body, in particular the general and pervasive feeling of exhaustion, limiting...

Jet lag is a ubiquitous problem for air travelers. As the process of rapidly shifting time zones leads to the body’s circadian rhythm being out of sync to the destination’s time schedule. This has a variety of impacts on the body, in particular the general and pervasive feeling of exhaustion, limiting an individual’s capacity to function, until acclimation. Therefore travelers, and especially business travelers, have a need for a method to help them prevent or overcome their jet lag rapidly.

The group of Prof. Gad Asher has discovered that specific oxygen conditions can help to rapidly overcome the symptoms of Jet Lag. The technology can be further developed into a device that can be used to treat individuals before and during flights to reduce jet lag.

Applications


  • Reduction of symptoms of Jet Lag


Technology's Essence


The basis of the discovery by the Asher group is examining and applying the role of oxygen to regulating the circadian rhythm. Experimenting both in vitro and in vivo in animal models, it was found that oxygen is an important regulator of the circadian rhythm. The mediation of oxygen as a circadian rhythm regulator is performed by HIF1? (hypoxia inducible factor 1?). In mouse models the Asher group found that a reduction of oxygen from 21% to ~16-14% led to an accelerated adaptation to Jet-lag like conditions. Simple human studies can be performed so as to translate these important findings.

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  • Prof. Gad Asher
1773
Treatment of multiple types of oncological malignancies, such as breast cancer involves the targeting one the of HER (EGFR/ErbB) family receptor tyrosine kinases. The challenge that arises in using a specific HER receptor for therapeutic applications is that the cancer can develop resistance to said...

Treatment of multiple types of oncological malignancies, such as breast cancer involves the targeting one the of HER (EGFR/ErbB) family receptor tyrosine kinases. The challenge that arises in using a specific HER receptor for therapeutic applications is that the cancer can develop resistance to said treatment. This tolerance arises due to compensatory mechanisms, such as the activation of alternate HER receptors. Consequently, there is a strong need to develop treatments that target HER receptors outside of the ubiquitously targeted HER1 and 2. In many cases it is HER3 which is responsible for such emergence of resistance.

The group of Prof. Yosef Yarden have developed a novel high affinity anti-HER3 antibody, to act either as an individual anti-cancer treatment or in combination with other therapies.  

Applications


  •  Cancer therapy

  •  Diagnostic tool


Technology's Essence


Prof. Yarden’s research group has developed a high affinity anti-HER3 antibody with a Kd in the range of 10 nM. The group tested the effectiveness of the antibody (termed N33) both in vitro and in xenografts. In all tested cases the anti-HER3 antibody showed promising effects in stopping cancer cell line growth and reducing tumor volume in mouse models.

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  • Prof. Yosef Yarden
1870
Alzheimer's disease, as well as other neurodegenerative disorders are characterized by damage to brain tissue. Immune cells within the brain participate in disease progression, whether by slowing it down or escalating disorders severity. Microglia are immune cells that reside within the central nervous...

Alzheimer's disease, as well as other neurodegenerative disorders are characterized by damage to brain tissue. Immune cells within the brain participate in disease progression, whether by slowing it down or escalating disorders severity. Microglia are immune cells that reside within the central nervous system (CNS) and participate in immune activity, particularly phagocytosis. As such, microglia can either contribute to or inhibit Alzheimer's progression, and manipulating them may provide a unique therapeutic option to treat Alzheimer's and other CNS-related disorders.

The groups of Profs. Ido Amit and Michal Schwartz used innovative single cell sequencing technologies in order to characterize these microglias and consequently discovered a series of potential immune checkpoints. Therefore, modulating these checkpoint targets could be a treatment for Alzheimer's disease and other diseases that are related to microglia dysfunction.

Applications


  • Neurodegenerative diseases

  • Microglia-related disorders

  • Novel Targets


Advantages


The Amit and Schwartz groups widely characterized DAMs by single-cell sequencing techniques and found a number of molecules that participate in their immune function. These DAMs were found not only in brains of mouse Alzheimer's model, but also in brains of humans with Alzheimer's that were analyzed post-mortem. The group also expanded the research to other neurodegenerative diseases in mice models, and confirmed DAM presence in these models as well. Therefore, these DAM regulatory molecules hold potential as treatment for a number of neurodegenerative.

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  • Prof. Michal Eisenbach-Schwartz

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