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Avaliable Technologies

Category
Technology Name
Briefcase
Scientist
1549
A tailor-made strategy for cancer treatment. The ErbB family of tyrosine kinase receptors and their ligands play important roles in development and tissue remodeling throughout adulthood. ErbB proteins are involved in several types of human cancer. Clinical studies indicate that over-expression of one...

A tailor-made strategy for cancer treatment. The ErbB family of tyrosine kinase receptors and their ligands play important roles in development and tissue remodeling throughout adulthood. ErbB proteins are involved in several types of human cancer. Clinical studies indicate that over-expression of one or more ErbB ligands correlates with decreased patient survival. The currently approved drugs for the treatment of cancers driven by the ErbB family target the receptors rather than the ligands, and they include either monoclonal anti-receptor antibodies, or tyrosine kinase inhibitors (TKIs). Because of resistance and moderate clinical efficacies of anti-receptor antibodies and TKIs it is worthwhile considering alternative strategies. The present technology combines several antibodies, capable of blocking ErbB ligands, with chemotherapy.

Applications


  • Treatment of cancers that possess the ErbB receptors (e.g. colorectal, liver, bladder, and head and neck tumors)

Advantages


  • Effective blockade of the tumorigenic action of ErbB-specific ligands
  • The combination protocol may enhance the sensitivity to chemotherapy

Technology's Essence


In the outlined technology, monoclonal antibodies were generated against two ligands, namely TGF-? and heparin-binding EGF-like growth factor. Combining the two antibodies with a chemotherapeutic drug enhanced the ability of chemotherapy to inhibit pancreatic tumors in mice. Therefore, this technology offers a general cancer therapeutic strategy that entails profiling the repertoire of growth factors secreted by a tumor, and combining with chemotherapy several antibodies capable of blocking autocrine ligands, in a way that sensitizes tumors to cytotoxicity and delays onset of chemoresistance.

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  • Prof. Yosef Yarden
1783
Aluminum and magnesium alloys are gaining more recognition for light-weight materials applications. In spite of this, such alloys have not been used for critical mechanical applications mainly due to their inferior mechanical properties compared to other engineering materials such as steel. Hence, many...

Aluminum and magnesium alloys are gaining more recognition for light-weight materials applications. In spite of this, such alloys have not been used for critical mechanical applications mainly due to their inferior mechanical properties compared to other engineering materials such as steel. Hence, many researchers have attempted to reinforce these alloys and obtain light-weight materials with excellent mechanical properties. The reinforcement process of the alloy can be achieved by introducing another material to form metal matrix composites. Different studies show that such composites exhibit improved properties, such as increased yield strength and tensile strength, enhanced stiffness, improved thermochemical properties, etc. However, the introduction of nanomaterials into the metal matrix is rather difficult due to the harsh manufacturing conditions employed for processing the metal composites.

The group of Prof. Reshef Tenne has developed state-of-the-art aluminum- and magnesium-based metal matrix composites, comprising small amounts of inorganic nanomaterials, such as nanotubes and spherical nanoparticles. The new nanocomposites exhibit much superior mechanical properties compared to the pristine alloy.

Applications


·         Automotive, transportation, and aerospace industries

·         Jet engine technologies

·         Electronics

·         Medical technologies


Advantages


·         Light-weight metal alloys

·         Excellent mechanical properties

·         Straight-forward fabrication technique


Technology's Essence


Aluminum (AA6061) and magnesium (AZ31) alloys were combined with small amounts (up to 1 wt.%) of either tungsten disulfide nanotubes or inorganic fullerene-like tungsten disulfide nanoparticles to form metal matrix composites using a melt-stirring reactor operated at high temperatures (up to 750oC). These nano-structures exhibit unique mechanical properties, which make their usage as composite fillers very promising, and a remarkable stability at elevated processing temperatures. Despite the small amounts of added nanostructures, their addition led to notable improvements in the mechanical properties of the alloys. Surprisingly, both the tensile strength of the alloys and their elongation (and consequently the fracture toughness) were improved by 10-20%. Depending on the nano-structure type and concentration, the hardness, yielding strength, ultimate tensile strength, and ductility were improved by up to ~70%. Physical considerations suggest that the main mechanism responsible for the reinforcement effect lies in the mismatch between the thermal expansion coefficients of the metal and the nano-structures.

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  • Prof. Reshef Tenne
1796
Oil is an important commodity in the global economy, used in numerous industries such as energy, cosmetics, food, personal care, and many more. However, oil based on petroleum is problematic due to finite supply, increasing environmental concerns, and regulations. Oils derived (?) from plant sources...

Oil is an important commodity in the global economy, used in numerous industries such as energy, cosmetics, food, personal care, and many more. However, oil based on petroleum is problematic due to finite supply, increasing environmental concerns, and regulations. Oils derived (?) from plant sources tend to compete with valuable arable land and consume fresh water.

Therefore oil sourced from algae as an alternative is an attractive option, as algae does not pollute, does not require arable land, and can use sea water. Yet current methods of producing oil from algae have limited net yields.

The present technology uses the virus EhV201 to modify the metabolism of microalgae Emiliania huxleyi to increase the production of high quality saturated and mono-unsaturated Triacylglycerides (TAGs). The method is simple to apply in increasing TAG content, does not perturb biomass production, and can even simplify the harvesting of the microalgae produced TAGs.

Applications


·         Directed production of Algal Oil from saturated and mono-unsaturated triacylglycerides for the production of high value products in the food, energy, cosmetics, and pharmaceutical industries.

·         Secondary and tertiary products can be co-extracted or generated from the TAGs and microalgae for different industrial uses:

o   Glycerol and fatty acids for food and cosmetics.

o   Algal cake (residual microalgae material) for animal feed, fertilizers, and so on.


Advantages


?  Straightforward procedure

?  High yield

?  No Genetic Modification

?  Simple and economical - no special equipment or conditions to induce TAG production

?  Scalable- as the EhV201 regenerates itself


Technology's Essence


The application of infecting E. huxleyi with EhV201, to increase triacylglyceride (TAG) production represents a promising innovation in creating an alternative source of oil. The system is simple to apply requiring minimal modification of current microalgae bioreactors. The use of the EhV201 to induce TAG production has been shown to be superior to current established methods of nutrient deprivation. Moreover, the technique does not require genetic modification of microalgae, avoiding regulatory challenges. Finally the technology also has added value being environmentally friendly, and possibly opening the avenue for claiming carbon credits, due to the carbon fixation of the microalgae.

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  • Ph.D. Assaf Vardi
  • Ph.D. Assaf Vardi
1736
Biomass production by plants and other photosynthetic organisms involves carbon fixation, the process of incorporating inorganic carbon dioxide into organic compounds. Currently carbon fixation by plants and other photosynthetic organisms is the limiting factor in biomass production. Improvement in the...

Biomass production by plants and other photosynthetic organisms involves carbon fixation, the process of incorporating inorganic carbon dioxide into organic compounds. Currently carbon fixation by plants and other photosynthetic organisms is the limiting factor in biomass production.

Improvement in the metabolic pathway related to carbon fixation would have great value in increasing crop yields, synthesizing high value compounds in algae, and developing means in removing CO2 from the atmosphere to combat climate change.

The present technology is an engineered E. coli with a carbon fixation pathway. The unique innovation can be used to efficiently screen the activity of RuBisCO, the most abundant carbon fixing enzyme on earth, which is further applicable to improving biomass production in different photosynthetic organisms such as plants and algae.

Applications


·      Powerful platform for screening and improving various enzymes in the carbon fixation process.

·      Unique metabolic pathway for use in Synthetic Biology applications.

·      Possible Carbon Credits for developing improved means of carbon fixation.


Advantages


·      E. coli is fast growing and easily manipulated by various genetic tools.

·      Novel source of biomass production.

·      Potentially low cost R&D system.


Technology's Essence


The technology functions by the recombinant insertion of two enzymes from the Calvin-Benson-Bassham (CBB) into E. coli, kinase prk and the carboxylating enzyme RuBisCO. With further modifications, the engineered E. coli’s metabolism was divided into two subsections. First a carbon fixing metabolism that can incorporate inorganic CO2 into sugar production, the second subsection consumes organic pyruvate to produce energy to drive the aforementioned carbon fixing cycle. Subsequently the technology is overall carbon neutral, but is an inexpensive and fast platform for screening improvements in the CBB carbon fixation pathway.

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  • Prof. Ron Milo
1786
Perovskites are a class of crystalline materials with a common complex chemical structure. Lead-halide hybrid organic-inorganic perovskites have recently emerged as highly efficient optoelectronic materials. Such materials are being intensively investigated and developed for photovoltaics,...

Perovskites are a class of crystalline materials with a common complex chemical structure. Lead-halide hybrid organic-inorganic perovskites have recently emerged as highly efficient optoelectronic materials. Such materials are being intensively investigated and developed for photovoltaics, photodetection, light-emitting diodes, and laser devices. Solar cells containing hybrid organic-inorganic perovskites have achieved over 20% certified efficiency.

Perovskites are most commonly synthesized by combining a metal salt (for example, a lead-based salt such as lead iodide) with an organic halide salt in a single step, by spin-coating from a solution of both salts, by co-evaporation, or by a two-step method of forming the metal salt film and subsequently exposing it to the organic halide. The existing fabrication methods suffer from high toxicity, complexity and high energy input.

We present a new method for the preparation of halide perovskites on a substrate for optoelectronic devices and solar cells, including tandem cells that produce higher voltages.

Applications


·      Solar cells

·      Other optoelectronic devices (e.g., photodetectors, light-emitting diodes, lasers)


Advantages


·      Reduced toxicity

·      Simple and straight-forward fabrication method

·      Excellent morphology control of the perovskites


Technology's Essence


Perovskites are crystalline materials with the formula ABX3, in which A and B are cations and X represents an anion. In hybrid organic–inorganic perovskites (HOIPs), A is an organic cation, B is a metal cation, and X is a halide anion.

The synthesis of HOIPs usually involves the use of toxic metal salts (for example, lead iodide or lead acetate) and organic solvents (such as dimethylformamide). Additionally, the combination of a metal salt with several organic solvents, such as dimethylsulfoxide, increases the toxicity of the solution in use.

The new fabrication method utilizes a metal or a metal alloy and an organic halide salt. In the first step, a layer comprising one of the components is deposited on a substrate. Then, the deposited layer is treated with a solution or a vapor of the second component to form a halide HOIP on a solid surface. This method provides a direct conversion of an elemental metal or a metal alloy to a halide perovskite or a perovskite related material. The main advantage of the presented method is the reduced toxicity of the solution used in the process. Additionally, the metals (mainly lead) are much less toxic in terms of manufacturing than the salts of the same metals.

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  • Prof. David Cahen
1795
Ultra-thin endoscopes are highly desirable for many applications involving remote imaging. Current ultra-thin endoscopes are primarily video-endoscopes and have a shaft diameter of 6 mm or less. Fiberscopes, on the other hand, can reach a micro-meter diameter, thus allowing examination of small,...

Ultra-thin endoscopes are highly desirable for many applications involving remote imaging. Current ultra-thin endoscopes are primarily video-endoscopes and have a shaft diameter of 6 mm or less. Fiberscopes, on the other hand, can reach a micro-meter diameter, thus allowing examination of small, difficult-to-reach, spaces for medical and other applications. Multimode fibers are being explored as ultra-thin lensless replacements for the commonly used endoscopes. The difficulty with imaging or focusing light through a multimode fiber is phase randomization of light propagating through the fiber, which results in a complex speckle pattern at the fiber output. To overcome this obstacle, an access to both fiber ends is required for pre-calibration.

A novel endoscopic method that was developed by Prof. Silberberg at the Weizmann Institute of Science allows light focusing through a multimode fiber by approaching solely the proximal end and retrieving information about the distal end using non-linear optical feedback.

Applications


·         Clinical imaging of narrow cavities (blood vessels, respiratory system, joints, etc.)

·         Selective targeting and burning of fluorescent targets (imaging and treatment)  


Advantages


  • Ultra-thin (micro-meter scale) and flexible

  • Lensless endoscopy

  • High resolution and accuracy


Technology's Essence


We consider a two-photon lensless multimode fiber-based endoscope, where an ultrashort pulse is delivered to a fluorescently tagged sample through the fiber. The pulses excite two photon fluorescence (2PF) from a 2PF screen placed against the fiber distal end. The back-propagated 2PF that is collected by the same fiber is separated from the excitation light at the proximal end by a dichroic mirror (DM), and the Fourier-transformed image of the fiber facet is recorded by an EMCCD camera. It is then used as feedback for a wavefront-shaping optimization algorithm, controlling a spatial light modulator (SLM) at the proximal fiber end. The nature of the light propagation in the fiber allows for scanning and controlling the focus position at the fiber distal end.

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  • Prof. Yaron Silberberg
1798
The rising demand for exclusive visual impact in many applications, along with escalating regulatory requirements drive the development of new, environmentally benign, pearlescent materials. Guanine, a common naturally mineralized material, is being used in a variety of products in industries, such as...

The rising demand for exclusive visual impact in many applications, along with escalating regulatory requirements drive the development of new, environmentally benign, pearlescent materials. Guanine, a common naturally mineralized material, is being used in a variety of products in industries, such as cosmetics, paints and jewelry due to its pearlescence effect. However, the industrial application of guanine crystals is limited since they are extracted from biological sources (mostly fish scales) with limited control over crystals dimensions, morphology and quantity for industrial applications. The main reasons impeding the use of synthetic guanine crystals are guanine insolubility in most solvents and the difficulty of obtaining crystals in the desired morphology. For these reasons, there is a thriving need for the development of a synthetic approach for the formation of well-defined anhydrous guanine crystals with tailor-made properties.

The new technology provides a novel synthetic method for the preparation of highly versatile pearlescent materials, based on guanine crystals, from aqueous solutions. The controllable size and shape of the resulting materials and the sustainability of the method make them suitable alternatives for the existing naturally occurring pearlescent pigments.

Applications


·      Cost-effective and environmentally-friendly approach

·      Control over crystals properties, including size and phase (anhydrous guanine and guanine monohydrate)

·      The same technology can be applied for the crystallization of other materials (purines and pteridines)


Advantages


·      Cosmetics and personal care products

·      Printing inks and decorative paints

·      Automotive paints.


Technology's Essence


Guanine is practically insoluble in neutral aqueous solutions. However, in aqueous acidic or basic solutions, where the molecules are ionized, guanine is much more soluble. The process involves dissolving guanine powder in either acidic or basic solutions, using HCl or NaOH, respectively, and then inducing crystallization by adjusting the pH of the solution. The crystal morphologies differ significantly when carrying out the crystallization in solutions adjusted to different pH regimes. Using pH induced crystallization, the interplay between the initial guanine concentration and the rate of pH change allow substantial control over the crystallization process and ultimately over the crystal size.

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  • Prof. Lia Addadi
1673
CF is the most common autosomal recessive disorder in western countries, affecting approximately 30,000 people in the US alone. A major risk in CF arises from chronic bacterial lung infections, affecting 80% of CF patients by the age of 25. Bacterial lung infections are also of major clinical...

CF is the most common autosomal recessive disorder in western countries, affecting approximately 30,000 people in the US alone. A major risk in CF arises from chronic bacterial lung infections, affecting 80% of CF patients by the age of 25. Bacterial lung infections are also of major clinical importance in patients with chronic obstructive pulmonary disease (COPD), trauma, burn wounds, sepsis, or in patients requiring ventilation. The infections are currently treated with antibiotics, which rapidly become inefficient as resistant bacteria strains arise. The present technology suggests a novel therapeutic approach for the prevention and treatment of bacterial lung infection in susceptible populations, especially CF patients

Applications


  • Alternative treatment for bacterial lung infections.
  • A prophylaxis for patients susceptible to bacterial lung infections

Advantages


  • A novel therapeutic approach to prevent or cure bacterial lung infection.
  • The new therapy is based on reinforcement of the physiological innate immunity rather than on antibiotics.
  • The new therapy can be easily administered, via inhalation.
  • FTY720, a SPH analog, is already in clinical use for treating multiple sclerosis.

Technology's Essence


Sphingosine (SPH), a natural bactericidal agent which acts as a part of the human innate immune system in the skin, was found to be an effective treatment and prophylaxis for bacterial lung infections in cystic fibrosis (CF) mice. The new technology is based on the discovery that both CF human patients and CF mice display reduced rates of SPH in the airways. Moreover, normalizing SPH levels by inhalation prevents or cures the infections in CF mice, thus rendering SPH and its analogs a potent therapeutic agent for CF patients, an alternative to antibiotics.

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  • Prof. Anthony H. Futerman
1780
A method based on Fast Neutron Resonance Transmission (FNRT) radiography that enables determining weight percentages of oil and water in thick, intact cores taken from subterranean or underwater geological formations. As part of geological exploitation to find oil and water, cores are extracted and...

A method based on Fast Neutron Resonance Transmission (FNRT) radiography that enables determining weight percentages of oil and water in thick, intact cores taken from subterranean or underwater geological formations. As part of geological exploitation to find oil and water, cores are extracted and tested to determine oil/water content.
This new method allows determining such content rapidly, in non- destructive, specific and quantities analysis of the cores.

Applications


  • Determining the identity and proportions of substances of oil and water content and their distribution in inspected cores

Advantages


  • A non-destructive method which enables to determine the fluid content along the entire length of an intact core or aggregate of cores within their protective sleeves.
  • More comprehensive information and considerable saving of analysis time compared to conventional sampling methods.
    Suitable for all types of rocks including tight-shale rocks.
  • This method enables to measure the weight fraction of oil and water in the core regardless of the core shape, thickness or distribution.
  • The fluid weight fractions in the samples are determined independently, thus the ratio of oil-to-rock weight-ratio is independent of the water content.
  • Due to high penetration of fast neutrons, the method is suitable for screening intact thick rock cores (10-15 cm), for which alternative probes, such as X-rays or slow neutrons suffer limited penetration.

Technology's Essence


In order to map the oil and water content and their distribution, an aggregate of intact cores within their protective sleeves is positioned on a moving conveyor belt and scanned by a broad- energy, fast- neutron beam. The neutrons are detected by a spectroscopic fast neutron imaging detector. The map of neutron-transmission spectra in each pixel provides information of oil/water content and distribution in such cores. 

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  • Prof. Amos Breskin
1710
Dysregulation of the immune system is the underlying cause of potentially fatal conditions such as sepsis and severe allergic reactions. Adequate therapies are currently absent or lacking. There is therefore an unmet medical need for therapies that would target the underlying causative immune pathways...

Dysregulation of the immune system is the underlying cause of potentially fatal conditions such as sepsis and severe allergic reactions. Adequate therapies are currently absent or lacking. There is therefore an unmet medical need for therapies that would target the underlying causative immune pathways.
Anti-microbial peptides (AMPs) possess promising anti-inflammatory activities, however, are commonly toxic.
In a series of newly synthesized peptides, the outlined invention provides a method to modify naturally occurring AMPs to possess both potent therapeutic anti-inflammatory activity and minimal toxicity in-vitro and in-vivo.
The resulting series of peptides were shown to remarkably inhibit severe allergic reaction as well.

Applications


  • Novel Therapy for sepsis and severe allergic reactions

Advantages


  • Very potent anti-inflammatory and anti-allergenic agents
  • Non-toxic
  • Targeted against the underlying cause of both indications, which is an improper and uncontrolled immune response
  • Diversity – elucidating the parameters that control efficiency and toxicity allows to modify the basic formula to optimally fit different systems

Technology's Essence


With natural AMPs properties in mind, Prof. Shai and his team characterized the key modifications that underline anti-inflammatory activity and toxicity. A series of peptides with variable degrees of hydrophobicity, length, charge, position of charge and amino acid chirality were tested for their LPS neutralizing activity.
It was found that ~20mer peptides under the formula Kn(AL)mKn (wherein n et each occurrence is independently 0-2, and m is 6-9) demonstrate anti-inflammatory activities at nanomolar concentrations as evident by inhibition of TNF? secretion from macrophages, following  LPS induction. Furthermore, a single dose of an exemplary peptide was able to inhibit septic shock in mice induced by purified LPS or by whole heat-killed E.coli.
In contrast to previous attempts, which focused on increasing hydrophobicity, the core of the present invention is the designation of an optimal hydrophobicity that is necessary for high activity and low toxicity. Additional important features for LPS neutralizing were found to be ?-helical structure and strong oligomerization ability.
Surprisingly, the present peptides were shown to contain highly potent anti-allergenic activity as well. In-vitro inhibition of Fc?RI-mediated degranulation was recapitulated in-vivo  

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  • Prof. Yechiel Shai
1750
Organophosphates are toxic compounds found in chemical warfare agents, such as nerve gases, and insect pesticides.Use of volatile nerve gas agents by terrorist organizations is a key concern of governments around the world. V-type nerve agents (e.g. VX, RVX, and CVX) are particularly toxic nerve gases...

Organophosphates are toxic compounds found in chemical warfare agents, such as nerve gases, and insect pesticides.
Use of volatile nerve gas agents by terrorist organizations is a key concern of governments around the world. V-type nerve agents (e.g. VX, RVX, and CVX) are particularly toxic nerve gases, with an exceptionally high potency. Although not as lethal as nerve agents, organophosphate insecticides can be harmful in large or prolonged doses. The standard therapy has limited efficacy, carry risks of serious adverse effects and have relatively short shelf life in field conditions.
Bioscavengers represent a preferred to rapidly detoxify organophosphates in the blood, before they had the chance to reach its physiological targets and cause damage, but usually require the use of very high doses.
The present invention provides genetically modified phosphotriesterase (PTE) variants, which serve as catalytic bioscavengers for V-type nerve agents, with exceptional detoxification activity at low doses, and improved stability.

Applications


  • Prophylactic or post exposure treatment for nerve gases attack, in particular V-type agents
  • Treatment for pesticides poisoning

Advantages


  • High catalytic activity – allow high efficacy at low doses
  • Reduced effective doses allows to reduce adverse effects
  • High stability increasing shelf life
  • Compatible with both prophylaxis and post exposure
  • Compatible for both surface decontamination and administration to patients

Technology's Essence


Researchers at Prof. Tawfik lab use directed evolution to drive protein mutagenesis towards desired traits. Appling this approach, using the actual threat agents, the present inventors generated recombinant phosphotriesterase (PTE) variants with improved catalytic efficiencies towards V-type nerve agent hydrolysis. Serving as catalytic bioscavengers, these recombinant PTE variants hydrolyze organophosphates without being consumed and thus can be applied at low doses (catalytic efficiency (kcat/KM) greater than 3.106 M-1min-1).
Importantly, PTE is efficient both as a prophylactic agent that may be given several hours prior to exposure as a preventive measure, and as post exposure antidote, even days after in a single or multiple-doses.
It is compatible with both decontamination of surfaces and detoxification administrated to a patient by standard routes such as orally or injectables.
Finally, some PTE variants show superior stability properties, retaining at least 50% of their catalytic activity at 50?C, indicating extended shelf life. This may be especially critical in field conditions, where the risk for nerve agent exposure is high.

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  • Prof. Dan S. Tawfik
1679
A novel therapy for Triple Negative Breast Cancer (TNBC) using mAbs combinationBreast cancer is the most common cancer in women worldwide. Triple-negative breast cancer (TNBC) representing about 15% of all breast cancer cases, is the deadliest form of all breast cancer subtypes, and tends to affect...

A novel therapy for Triple Negative Breast Cancer (TNBC) using mAbs combination
Breast cancer is the most common cancer in women worldwide. Triple-negative breast cancer (TNBC) representing about 15% of all breast cancer cases, is the deadliest form of all breast cancer subtypes, and tends to affect women at a younger age. Unfortunately TNBC cannot be treated with the common receptor targeted therapies since it does not express these targets, the estrogen, progesterone and Her2/neu receptors. Therefor systemic treatment options are currently limited to cytotoxic chemotherapy. The lack of effective targeted therapies, resistance to chemotherapy, and early metastatic spread have contributed to the poor prognoses and outcomes associated with TNBC.
The current technology offers a novel therapeutic strategy for TNBC. The application of two novel, noncompetitive antibodies against EGFR, achieves a robust degradation EGFR resulting in tumor inhibition.

Applications


  • Novel and unique antibody targeted therapy for TNBC.
  • The novel anti EGFR antibodies can cooperate synergistically with the currently marketed EGFR antibodies.

Advantages


  • A promising therapeutic scenario to treat TNBC.
  • Enhanced EGFR degradation and improved anti-tumor activity, in contrast to clinically approved anti-EGFR mAbs, which display no cooperative effects.
  • Lysosomal EGFR degradation pathway induced by epitope-distinct antibody mixture may potentially lead to improved therapeutic outcome, and reduced resistance.

Technology's Essence


Prof. Yosef Yarden and his team demonstrated that a combination of novel antibodies that target distinct regions on the human EGF receptor resulted in its robust and synergistic down-regulation, leading to pronounced tumor growth inhibition. Furthermore, the combined mAbs induced lysosomal degradation of EGFR, while avoiding the recycling route. Such irreversible mode of EGFR degradation may potentially increase response rate or delay the onset of patient resistance.
Conversely, combining cetuximab and panitumumab, the mAbs routinely used to treat colorectal cancer patients, did not improve receptor degradation because they are both attracted to the same epitope on EGFR.

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  • Prof. Yosef Yarden
1799
A new computer graphics tool for the efficient and robust deformation of 2D images was developed by the group of Prof. Lipman. Space deformation is an important tool in graphics and image processing, with applications ranging from image warping and character animation, to non-rigid registration and...

A new computer graphics tool for the efficient and robust deformation of 2D images was developed by the group of Prof. Lipman.

Space deformation is an important tool in graphics and image processing, with applications ranging from image warping and character animation, to non-rigid registration and shape analysis. Virtually all methods attempt to find maps that possess three key properties: smoothness, injectivity and shape preservation. Furthermore, for the purpose of warping and posing characters, the method should have interactive performance. However, there is no known method that possesses all of these properties.

Previous deformation models can be roughly divided into meshbased and meshless models. Mesh-based maps are predominantly constructed using linear finite elements, and are inherently not smooth, but can be made to look smooth by using highly dense elements. Although the methods for creating maps with controlled distortion exist, they are time-consuming, and dense meshes prohibit their use in an interactive manner. On the other hand, meshless maps are usually defined using smooth bases and hence are smooth themselves. Yet we are unaware of any known technique that ensures their injectivity and/or bounds on their distortion.

The new method presented here bridges the gap between mesh and meshless methods, by providing a generic framework for making any smooth function basis suitable for deformation.

Applications


  • Computer graphics and animation
  • Image registration for medical imaging, satellite imaging and military applications

Advantages


  • Robust, fast, efficient and scalable

  • Generic, can be applied to various scenarios

  • Possesses smoothness, injectivity and shape preservation with interactive performance


Technology's Essence


Deformation od 2D images is accomplished by enabling direct control over the distortion of the Jacobian during optimization, including preservation of orientation (to avoid flips). The method generates maps by constraining the Jacobian on a dense set of ”collocation” points, using an active-set approach. Only a sparse subset of the collocation points needs to be active at every given moment, resulting in fast performance, while retaining the distortion and injectivity guarantees. Furthermore, a precise mathematical relationship between the density of the collocation points, the maximal distortion achieved on them, and the maximal distortion achieved everywhere in the domain of interest is derived.

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  • Prof. Ronen Ezra Basri
1715
Preparation of Re-doped inorganic MoS2 nanoparticles with good sodium ion reversible intercalation properties, to be used as cathode material for next generation sodium ion batteries. Lithium ion batteries (LIB) are currently the leading energy storage solution used in many applications. But lithium is...

Preparation of Re-doped inorganic MoS2 nanoparticles with good sodium ion reversible intercalation properties, to be used as cathode material for next generation sodium ion batteries.
Lithium ion batteries (LIB) are currently the leading energy storage solution used in many applications. But lithium is both toxic and limited in quantity (hence expensive) and cannot supply the growing demand for energy storage units as well as the need for cleaner and safer technologies.
Sodium ion batteries (SIB) are attractive new generation batteries as they incorporate the much less toxic and much more abundant sodium ion.
Our novel nanoparticles were shown to have competitive electrochemical performances with specific capacity of about 130 mAh/g at 2C and 74 mAh/g at high discharge rate of 20C.

Applications


  • Electrode material for sodium ion batteries
  • Possible applications in magnesium ion batteries

Advantages


  • Competitive specific capacity
  • Improved electrical conductivity towards Na ions

Technology's Essence


The cathode material's reversible intercalation capacity plays a significant role in determining the total capacity of an energy cell. Intercalation requires entering of ions into the electrode material through diffusion channels.
The faceted structure of inorganic nanoparticles (IF) induces intrinsic dislocations and stacking faults which serve as ion diffusion channels. Doping of the nanoparticles increases both conductivity, due to n-type doping of the Mo metal, and the number of structural defects (hence diffusion channels), resulting in total increased electrical conductivity.
The synthetic procedure for producing Re-doped MoS2 nanoparticles is straightforward, based on known and published protocols.

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  • Prof. Reshef Tenne
1752
Heart failure is the leading cause of death in the western world. Existing treatments fail to compensate the irreversible loss of functional cardiomyocytes (CM), thus presenting a major medical unmet need. Inducing native CM replacement is one approach being tested as regenerative treatment, with the...

Heart failure is the leading cause of death in the western world.
Existing treatments fail to compensate the irreversible loss of functional cardiomyocytes (CM), thus presenting a major medical unmet need. Inducing native CM replacement is one approach being tested as regenerative treatment, with the advantage of a more straightforward methodology over cell transplantation approaches. 
In a multidisciplinary study, headed by Prof. Eldad Tzahor from the Weizmann institute of Science, the tyrosine kinase ERBB2 was shown to be both necessary for CM proliferation and sufficient to reactivate postnatal CM proliferative and regenerative potentials.
Thus, potentiation of ERBB2 signalling in adult CMs might represent a promising therapeutic approach for CM replacement in heart failure.

Applications


  • Induction of cardiomyocytes replacement therapy following heart injury.

Advantages


  • Straightforward methodology – Avoids complications associated with the requirement for cell transplantation.
  • Include several optional targets - both ERRB2 and its downstream effectors serve as potential targets for therapeutic agents, which may be administrated in combination, to increase chances for successes. 

Technology's Essence


The ligand-receptor network consisting of NRG1, and its tyrosine kinase receptors ERBB4, ERBB3 and ERBB2, plays critical roles during heart development.
In a multidisciplinary study, headed by prof. Eldad Tzahor from the Weizmann institute of Science, ERBB2 was shown to be necessary and limiting for NRG1-induced CM proliferation in the neonate.
Inspired by this finding, the team examined the possibility to use ERBB2 as a target for induced cell proliferation and regeneration in adult hearts. Using loss- and gain-of-function genetic experiments in mice, they reveal that NRG1/ERBB2 signalling is both essential for CM proliferation and heart integrity in the neonatal period, and sufficient to prolong the postnatal proliferative and regenerative windows.
Regeneration was shown to be a result of increased CM dedifferentiation and proliferation accompanied by neovascularization and followed by redifferentiation, tissue replacement with reduced scar formation and restoration of function.
Thus, these finding highlight ERBB2 as a strong target for heart regeneration treatments as well as its downstream effectors.

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  • Prof. Eldad Tzahor

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