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Avaliable Technologies

Category
Technology Name
Briefcase
Scientist
1549
A tailor-made strategy for cancer treatment. The ErbB family of tyrosine kinase receptors and their ligands play important roles in development and tissue remodeling throughout adulthood. ErbB proteins are involved in several types of human cancer. Clinical studies indicate that over-expression of one...

A tailor-made strategy for cancer treatment. The ErbB family of tyrosine kinase receptors and their ligands play important roles in development and tissue remodeling throughout adulthood. ErbB proteins are involved in several types of human cancer. Clinical studies indicate that over-expression of one or more ErbB ligands correlates with decreased patient survival. The currently approved drugs for the treatment of cancers driven by the ErbB family target the receptors rather than the ligands, and they include either monoclonal anti-receptor antibodies, or tyrosine kinase inhibitors (TKIs). Because of resistance and moderate clinical efficacies of anti-receptor antibodies and TKIs it is worthwhile considering alternative strategies. The present technology combines several antibodies, capable of blocking ErbB ligands, with chemotherapy.

Applications


  • Treatment of cancers that possess the ErbB receptors (e.g. colorectal, liver, bladder, and head and neck tumors)

Advantages


  • Effective blockade of the tumorigenic action of ErbB-specific ligands
  • The combination protocol may enhance the sensitivity to chemotherapy

Technology's Essence


In the outlined technology, monoclonal antibodies were generated against two ligands, namely TGF-? and heparin-binding EGF-like growth factor. Combining the two antibodies with a chemotherapeutic drug enhanced the ability of chemotherapy to inhibit pancreatic tumors in mice. Therefore, this technology offers a general cancer therapeutic strategy that entails profiling the repertoire of growth factors secreted by a tumor, and combining with chemotherapy several antibodies capable of blocking autocrine ligands, in a way that sensitizes tumors to cytotoxicity and delays onset of chemoresistance.

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  • Prof. Yosef Yarden
1783
Magnesium and aluminum alloys are gaining more recognition as a lightest structural material for light-weight applications due to their low density and high stiffness-to-weight ratio. In spite of this, such alloys have not been used for critical mechanical applications mainly due to their inferior...

Magnesium and aluminum alloys are gaining more recognition as a lightest structural material for light-weight applications due to their low density and high stiffness-to-weight ratio. In spite of this, such alloys have not been used for critical mechanical applications mainly due to their inferior mechanical properties compared to other engineering materials such as steel. Hence, many researchers have attempted to reinforce these alloys and obtain light-weight materials with excellent mechanical properties. Thermomechanical treatments are often used to improve the mechanical properties of light alloys, however at the cost of faster corrosion and wear. The reinforcement process of the alloy is achieved by introducing another material to form magnesium- and aluminum-based metal matrix composites. Different studies show that such composites exhibit improved properties. In recent years, ceramic nanoparticles have been used to reinforce different metallic materials to form the metal matrix composites. The introduction of nanomaterials into the metal matrix is rather difficult due to the harsh manufacturing conditions employed for processing the metal composites.

The group of Prof. Reshef Tenne has developed state-of-the-art magnesium- and aluminum-based metal matrix composites, comprising small amounts of inorganic nanomaterials, such as nanotubes and spherical nanoparticles. The new nanocomposites exhibit much superior mechanical properties compared to the pristine alloy.

Applications


·         Automotive, transportation, and aerospace industries

·         Jet engine technologies

·         Electronics

·         Medical technologies


Advantages


  • Light-weight metal alloys

  • Excellent mechanical properties

  • Straight-forward fabrication technique


Technology's Essence


Magnesium and aluminum alloys were combined with small amounts (up to 1 wt%) of either tungsten disulfide nanotubes or inorganic fullerene-like tungsten disulfide nanoparticles to form metal matrix composites using a melt-stirring reactor operated at >700?C. The nanostructures were remarkably stable at these elevated processing temperatures and were found to be uniformly distributed. Despite the small amounts of added nanostructures, their addition led to remarkable improvements in the mechanical properties of the alloys. Surprisingly, both the tensile strength of the alloys and their elongation (and consequently the fracture toughness) were improved by 10-20%.

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  • Prof. Reshef Tenne
1796
Oil is an important commodity in the global economy, used in numerous industries such as energy, cosmetics, food, personal care, and many more. However, oil based on petroleum is problematic due to finite supply, increasing environmental concerns, and regulations. Oils derived (?) from plant sources...

Oil is an important commodity in the global economy, used in numerous industries such as energy, cosmetics, food, personal care, and many more. However, oil based on petroleum is problematic due to finite supply, increasing environmental concerns, and regulations. Oils derived (?) from plant sources tend to compete with valuable arable land and consume fresh water.

Therefore oil sourced from algae as an alternative is an attractive option, as algae does not pollute, does not require arable land, and can use sea water. Yet current methods of producing oil from algae have limited net yields.

The present technology uses the virus EhV201 to modify the metabolism of microalgae Emiliania huxleyi to increase the production of high quality saturated and mono-unsaturated Triacylglycerides (TAGs). The method is simple to apply in increasing TAG content, does not perturb biomass production, and can even simplify the harvesting of the microalgae produced TAGs.

Applications


·         Directed production of Algal Oil from saturated and mono-unsaturated triacylglycerides for the production of high value products in the food, energy, cosmetics, and pharmaceutical industries.

·         Secondary and tertiary products can be co-extracted or generated from the TAGs and microalgae for different industrial uses:

o   Glycerol and fatty acids for food and cosmetics.

o   Algal cake (residual microalgae material) for animal feed, fertilizers, and so on.


Advantages


?  Straightforward procedure

?  High yield

?  No Genetic Modification

?  Simple and economical - no special equipment or conditions to induce TAG production

?  Scalable- as the EhV201 regenerates itself


Technology's Essence


The application of infecting E. huxleyi with EhV201, to increase triacylglyceride (TAG) production represents a promising innovation in creating an alternative source of oil. The system is simple to apply requiring minimal modification of current microalgae bioreactors. The use of the EhV201 to induce TAG production has been shown to be superior to current established methods of nutrient deprivation. Moreover, the technique does not require genetic modification of microalgae, avoiding regulatory challenges. Finally the technology also has added value being environmentally friendly, and possibly opening the avenue for claiming carbon credits, due to the carbon fixation of the microalgae.

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  • Ph.D. Assaf Vardi
  • Ph.D. Assaf Vardi
1736
Biomass production by plants and other photosynthetic organisms involves carbon fixation, the process of incorporating inorganic carbon dioxide into organic compounds. Currently carbon fixation by plants and other photosynthetic organisms is the limiting factor in biomass production. Improvement in the...

Biomass production by plants and other photosynthetic organisms involves carbon fixation, the process of incorporating inorganic carbon dioxide into organic compounds. Currently carbon fixation by plants and other photosynthetic organisms is the limiting factor in biomass production.

Improvement in the metabolic pathway related to carbon fixation would have great value in increasing crop yields, synthesizing high value compounds in algae, and developing means in removing CO2 from the atmosphere to combat climate change.

The present technology is an engineered E. coli with a carbon fixation pathway. The unique innovation can be used to efficiently screen the activity of RuBisCO, the most abundant carbon fixing enzyme on earth, which is further applicable to improving biomass production in different photosynthetic organisms such as plants and algae.

Applications


·      Powerful platform for screening and improving various enzymes in the carbon fixation process.

·      Unique metabolic pathway for use in Synthetic Biology applications.

·      Possible Carbon Credits for developing improved means of carbon fixation.


Advantages


·      E. coli is fast growing and easily manipulated by various genetic tools.

·      Novel source of biomass production.

·      Potentially low cost R&D system.


Technology's Essence


The technology functions by the recombinant insertion of two enzymes from the Calvin-Benson-Bassham (CBB) into E. coli, kinase prk and the carboxylating enzyme RuBisCO. With further modifications, the engineered E. coli’s metabolism was divided into two subsections. First a carbon fixing metabolism that can incorporate inorganic CO2 into sugar production, the second subsection consumes organic pyruvate to produce energy to drive the aforementioned carbon fixing cycle. Subsequently the technology is overall carbon neutral, but is an inexpensive and fast platform for screening improvements in the CBB carbon fixation pathway.

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  • Prof. Ron Milo
1786
Perovskites are a class of crystalline materials with a common complex chemical structure. Lead-halide hybrid organic-inorganic perovskites have recently emerged as highly efficient optoelectronic materials. Such materials are being intensively investigated and developed for photovoltaics,...

Perovskites are a class of crystalline materials with a common complex chemical structure. Lead-halide hybrid organic-inorganic perovskites have recently emerged as highly efficient optoelectronic materials. Such materials are being intensively investigated and developed for photovoltaics, photodetection, light-emitting diodes, and laser devices. Solar cells containing hybrid organic-inorganic perovskites have achieved over 20% certified efficiency.

Perovskites are most commonly synthesized by combining a metal salt (for example, a lead-based salt such as lead iodide) with an organic halide salt in a single step, by spin-coating from a solution of both salts, by co-evaporation, or by a two-step method of forming the metal salt film and subsequently exposing it to the organic halide. The existing fabrication methods suffer from high toxicity, complexity and high energy input.

We present a new method for the preparation of halide perovskites on a substrate for optoelectronic devices and solar cells, including tandem cells that produce higher voltages.

Applications


·      Solar cells

·      Other optoelectronic devices (e.g., photodetectors, light-emitting diodes, lasers)


Advantages


·      Reduced toxicity

·      Simple and straight-forward fabrication method

·      Excellent morphology control of the perovskites


Technology's Essence


Perovskites are crystalline materials with the formula ABX3, in which A and B are cations and X represents an anion. In hybrid organic–inorganic perovskites (HOIPs), A is an organic cation, B is a metal cation, and X is a halide anion.

The synthesis of HOIPs usually involves the use of toxic metal salts (for example, lead iodide or lead acetate) and organic solvents (such as dimethylformamide). Additionally, the combination of a metal salt with several organic solvents, such as dimethylsulfoxide, increases the toxicity of the solution in use.

The new fabrication method utilizes a metal or a metal alloy and an organic halide salt. In the first step, a layer comprising one of the components is deposited on a substrate. Then, the deposited layer is treated with a solution or a vapor of the second component to form a halide HOIP on a solid surface. This method provides a direct conversion of an elemental metal or a metal alloy to a halide perovskite or a perovskite related material. The main advantage of the presented method is the reduced toxicity of the solution used in the process. Additionally, the metals (mainly lead) are much less toxic in terms of manufacturing than the salts of the same metals.

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  • Prof. David Cahen
1798
The rising demand for exclusive visual impact in many applications, along with escalating regulatory requirements drive the development of new, environmentally benign, pearlescent materials. Guanine, a common naturally mineralized material, is being used in a variety of products in industries, such as...

The rising demand for exclusive visual impact in many applications, along with escalating regulatory requirements drive the development of new, environmentally benign, pearlescent materials. Guanine, a common naturally mineralized material, is being used in a variety of products in industries, such as cosmetics, paints and jewelry due to its pearlescence effect. However, the industrial application of guanine crystals is limited since they are extracted from biological sources (mostly fish scales) with limited control over crystals dimensions, morphology and quantity for industrial applications. The main reasons impeding the use of synthetic guanine crystals are guanine insolubility in most solvents and the difficulty of obtaining crystals in the desired morphology. For these reasons, there is a thriving need for the development of a synthetic approach for the formation of well-defined anhydrous guanine crystals with tailor-made properties.

The new technology provides a novel synthetic method for the preparation of highly versatile pearlescent materials, based on guanine crystals, from aqueous solutions. The controllable size and shape of the resulting materials and the sustainability of the method make them suitable alternatives for the existing naturally occurring pearlescent pigments.

Applications


·      Cost-effective and environmentally-friendly approach

·      Control over crystals properties, including size and phase (anhydrous guanine and guanine monohydrate)

·      The same technology can be applied for the crystallization of other materials (purines and pteridines)


Advantages


·      Cosmetics and personal care products

·      Printing inks and decorative paints

·      Automotive paints.


Technology's Essence


Guanine is practically insoluble in neutral aqueous solutions. However, in aqueous acidic or basic solutions, where the molecules are ionized, guanine is much more soluble. The process involves dissolving guanine powder in either acidic or basic solutions, using HCl or NaOH, respectively, and then inducing crystallization by adjusting the pH of the solution. The crystal morphologies differ significantly when carrying out the crystallization in solutions adjusted to different pH regimes. Using pH induced crystallization, the interplay between the initial guanine concentration and the rate of pH change allow substantial control over the crystallization process and ultimately over the crystal size.

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  • Prof. Lia Addadi
1795
Ultra-thin endoscopes are highly desirable for many applications involving remote imaging. Current ultra-thin endoscopes are primarily video-endoscopes and have a shaft diameter of 6 mm or less. Fiberscopes, on the other hand, can reach a micro-meter diameter, thus allowing examination of small,...

Ultra-thin endoscopes are highly desirable for many applications involving remote imaging. Current ultra-thin endoscopes are primarily video-endoscopes and have a shaft diameter of 6 mm or less. Fiberscopes, on the other hand, can reach a micro-meter diameter, thus allowing examination of small, difficult-to-reach, spaces for medical and other applications. Multimode fibers are being explored as ultra-thin lensless replacements for the commonly used endoscopes. The difficulty with imaging or focusing light through a multimode fiber is phase randomization of light propagating through the fiber, which results in a complex speckle pattern at the fiber output. To overcome this obstacle, an access to both fiber ends is required for pre-calibration.

A novel endoscopic method that was developed by Prof. Silberberg at the Weizmann Institute of Science allows light focusing through a multimode fiber by approaching solely the proximal end and retrieving information about the distal end using non-linear optical feedback.

Applications


·         Clinical imaging of narrow cavities (blood vessels, respiratory system, joints, etc.)

·         Selective targeting and burning of fluorescent targets (imaging and treatment)  


Advantages


  • Ultra-thin (micro-meter scale) and flexible

  • Lensless endoscopy

  • High resolution and accuracy


Technology's Essence


We consider a two-photon lensless multimode fiber-based endoscope, where an ultrashort pulse is delivered to a fluorescently tagged sample through the fiber. The pulses excite two photon fluorescence (2PF) from a 2PF screen placed against the fiber distal end. The back-propagated 2PF that is collected by the same fiber is separated from the excitation light at the proximal end by a dichroic mirror (DM), and the Fourier-transformed image of the fiber facet is recorded by an EMCCD camera. It is then used as feedback for a wavefront-shaping optimization algorithm, controlling a spatial light modulator (SLM) at the proximal fiber end. The nature of the light propagation in the fiber allows for scanning and controlling the focus position at the fiber distal end.

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  • Prof. Yaron Silberberg
1802
A new signal processing tool for the detection of pulses travelling through media with complex or unknown dispersion properties was developed by the group of Prof. Gal-Yam, originally for detecting radio bursts in astronomical observations. Pulses are applied in various fields such as oil & gas...

A new signal processing tool for the detection of pulses travelling through media with complex or unknown dispersion properties was developed by the group of Prof. Gal-Yam, originally for detecting radio bursts in astronomical observations.
Pulses are applied in various fields such as oil & gas exploration, detection (e.g. sonar, lidar and radar) and communication. When pulses pass through dispersive media, the arrival times at the detector of different frequency components may differ, and as a result the pulse may become degraded (e.g. transformed to a longer pulse with reduced intensity), even to the level of becoming indistinguishable in terms of signal to noise. This problem becomes even more challenging when detecting short pulses that travel through complex or unknown media.
The new method presented here provides a proven and efficient solution that can be applied for different scenarios where short pulses dispersed by complex media are used. 

Applications


  • Detection and surveying technologies- sonar, lidar, radar etc

Advantages


  • Efficient, requires limited computational resources
  • Generic, can be applied to various setups
  • Easily implementable into existing systems

Technology's Essence


The method includes obtaining an input array of cells, each indicating an intensity of a frequency component of the signal at a representative time. A fast dispersion measure transform (FDMT) is applied to concurrently sum the cells of the input array that lie along different dispersion curves, each curve defined by a known non-linear functional form and being uniquely characterized by a time coordinate and by a value of the dispersion measure. Application of FDMT includes initially generating a plurality of sub-arrays, each representing a frequency sub-band and iteratively combining pairs of adjacent sub-arrays in accordance with an addition rule until all of the initially generated plurality of sub-arrays are combined into an output array of the sums, in which a cell of the output array that is indicative of a transmitted pulse is identified.

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  • Prof. Avishay Gal-Yam
1730
Production of carbon nanotube based transistors through a process comprised of identification, selection, and placement of pristine carbon nanotubes in conjunction with standard electrical circuitry.Semiconductor devices are vital to everyday life, however conventional semiconducting materials are...

Production of carbon nanotube based transistors through a process comprised of identification, selection, and placement of pristine carbon nanotubes in conjunction with standard electrical circuitry.
Semiconductor devices are vital to everyday life, however conventional semiconducting materials are quickly approaching their limitations. As devices transition from the microscale to the nanoscale, new techniques for their assembly and testing of their properties must be created. Controllable nanofabrication methods are of increasing importance across a wide field of electronics in everything from energy efficient LEDs in flat-screen monitors to transistors for ultra-powerful computers. Our process presents a novel method for producing high quality nanoscale carbon nanotube based transistors. These methods will be of the utmost importance in the forthcoming nano-revolution.

Applications


  • Produce flawless carbon nanotubes
  • Identify, select, and position nanotubes with precision
  • Room temperature operation
  • High sensitivity
  • High resolution

Advantages


  • Single electron transistor (SET) nanoscale imaging
  • Novel nano-electromechanical devices

Technology's Essence


The principle behind this technology is two-fold: 1) Synthesis and selection method of flawless carbon nanotubes, and 2) their combination with nanoscale electric circuitry to form fully controlled composite nanoscale electronic device.
Selection of the carbon nanotube(s) is assisted by a scanning probe microscope (SPM). A composite electronic device is assembled from two separated chips; a nanotube chip where nanotubes are grown over wide trenches, and a standard circuit chip with electrode contacts surrounding the gates to be measured. The nano-assembly is achieved by inserting an SPM cantilever into a trench on the nanotube chip and placing the circuit chip over a suitable nanotube. Once in place, the nanotube is cut locally by passing a strong current between the electrode contacts, and the composite chip is formed.
This composite electronic device can be used to map electronic potentials with high resolution of 100 nm, high sensitivity of 1microV/Hz1/2, at frequencies of 100 MHz and more and all this at room temperature.

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  • Prof. Shahal Ilani
1690
Optimal growth and metabolic activities of Lactic Acid Bacterial (LAB) starters are critical for assuring high-quality fermentation in the manufacturing process of numerous dairy products. Despite extensive efforts, phage infection of starter cultures for dairy processing remains the most common cause...

Optimal growth and metabolic activities of Lactic Acid Bacterial (LAB) starters are critical for assuring high-quality fermentation in the manufacturing process of numerous dairy products. Despite extensive efforts, phage infection of starter cultures for dairy processing remains the most common cause of slow or incomplete fermentation and product downgrading. Standard anti-phage measures (sanitation, culture handling) fail to provide sufficient protection, exposing the production process to massive economic setbacks.
Extensive R&D efforts have led to the discovery of phage resistance systems, however many phages can circumvent these systems, and in addition not all LABs can accommodate them.
Therefore, there is a strong need for additional defense systems that could naturally protect LABs against phages.
The Sorek laboratory at the Weizmann Institute of Science has recently identified hundreds of novel functional toxin/antitoxin systems in bacterial genomes. These systems were discovered using analysis of data from millions of shotgun cloning experiments across 388 bacterial species. Acting as an abortive infection agent to prevent phage spread, some of these systems were already validated as conferring resistance against phage infection upon introduction to E.coli cells.
In another novel technology, researchers at Dr. Rotem Sorek’s lab identified a novel anti phage gene cassette, termed BREX (Bacteriophage Exclusion), which confers complete or partial resistance against phages spanning a wide phylogeny of phage types, including lytic and temperate ones.

Applications


  • Tools for conferring anti-phage traits to bacterial starters.

Advantages


  • Provides efficient phage-resistance features.
  • Robust: confers resistance to a broad range of phages, including both lytic and temperate ones.
  • General: the same defense system may be applied in various cultures, not confined to specific strains.
  • Novel systems, provides a fresh approach to the field of phage resistance 

Technology's Essence


Toxin/antitoxin (TA) modules, composed of a toxic protein and a counteracting antitoxin, are proposed to function in phage defense via abortive infection. The two genes, which reside on the same operon, code for small proteins where inhibition of the toxin is carried out through protein-protein interaction. Upon a specific signal (phage infection) the antitoxin degrades rapidly by one of the housekeeping bacterial proteases, resulting in either bacteriocidic (cell-killing) or bacteriostatic (growth-inhibiting) effects, thus protecting the colony against phage spread. The inventors took advantage of the concept that toxins could only be cloned when the neighboring antitoxin was present on the same clone to systematically reveal active TA pairs. Following extensive statistical and experimental validations, 8 novel families of TA pairs that are likely to play a role in phage defense were identified. By introducing these systems into new bacteria, the inventors showed that the toxin/antitoxin pairs could protect the engineered bacteria from phage infection.
BREX is a novel cassette of six genes that confers protection against a wide range of phages, including virulent and temperate ones. This cassette is composed of genes not typically found in other defense systems, and hence employs a novel mechanism of anti-phage protection. Scientists at the Sorek lab further uncovered the mode of action of this novel system. It was shown that the system is not an abortive infection system (i.e., does not lead to suicide of the infected cell), and that it allows phage adsorption but blocks phage replication in a DNA degradation independent manner.

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  • Prof. Rotem Sorek
1765
A new image reconstruction tool based on non-iterative phase information retrieval from a single diffraction pattern was developed by the group of Prof. Oron.  Lensless imaging techniques enable indirect high resolution observation of objects by measuring the intensity of their diffraction patterns....

A new image reconstruction tool based on non-iterative phase information retrieval from a single diffraction pattern was developed by the group of Prof. Oron. 
Lensless imaging techniques enable indirect high resolution observation of objects by measuring the intensity of their diffraction patterns. These techniques utilize radiation in the X-ray regime to image non-periodic objects in sizes that prohibit the use of larger wavelengths. However, retrieving the phase information of the diffraction pattern is not a trivial task, as current methods are divided based on a tradeoff between experimental complexity and computational reconstruction efficiency.
The method described here is suitable for use with existing lensless imaging techniques to provide direct, robust and efficient phase data while requiring reduced computational and experimental complexity. This method, demonstrated in a laboratory setup on 2D objects, is also applicable in 1D. It can be applied to various phase retrieval applications such as coherent diffractive imaging and ultrashort pulse reconstruction

Applications


  • Phase microscopy
  • Signal processing
  • Holography
  • X-ray imaging

Advantages


  • A Generic solution to the phase retrieval problem
  • Non-iterative approach
  • An efficient and noise robust tool

Technology's Essence


The method is based on the fact that the Fourier transform of the diffraction intensity measurement is the autocorrelation of the object. The autocorrelation and cross-correlations of two sufficiently separated objects are spatially distinct. Based on this, the method consists of three main steps: (a) The sum of the objects’ autocorrelations, as well as their cross-correlation, are reconstructed from the Fourier transform of the measured diffraction pattern. (b) The individual objects’ autocorrelations are reconstructed from their sum and the cross-correlation. (c) Using the two intensities and the interference cross term, double-blind Fourier holograph is applied to recover the phase by solving a set of linear equations.

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  • Prof. Dan Oron
1670
A method for selective extraction of precious and rare metals has been developed at the Weizmann Institute. This method allows the efficient and environmentally benign recovery of precious materials that are currently discarded of in large quantities from spent catalysts (automotive and industrial)...

A method for selective extraction of precious and rare metals has been developed at the Weizmann Institute. This method allows the efficient and environmentally benign recovery of precious materials that are currently discarded of in large quantities from spent catalysts (automotive and industrial) from industrial processes (particularly in the electronic industry).

Prof. Igor Lubomirsky’s novel process is based on volatilization for selective extraction of precious and rare metals using benign metal salts, rather than dangerous chlorine gas as a chlorinating agent. The new process requires relatively low temperatures and is free from hazardous waste, among its additional advantages over conventional methods.

We believe that this efficient technology is key to increased reclaimed precious metals output, potentially resulting in the reduction of the demand for primary rare metals.

Applications


·           Recycling precious metals from spent items, e.g. platinum group metals from catalytic convertors


Advantages


·         No toxic input – chlorides are used rather than chlorine gas.

·         No hazardous waste is generated in the process.

·         Mild conditions. High-temperature furnaces and equipment are not required.

·         Relatively simple setup in comparison to conventional ones.

·         Small scale plants are economically viable.


Technology's Essence


Prof. Igor Lubomirsky and his group developed a novel method for the recovery of PGM from spent catalysts that can be applicable for other spent systems as well.

The method comprises of crushing the spent catalyst to obtain a catalyst particulate material with g a predetermined grain size and reacting it with chlorine containing salts rather than pure chlorine gas in a furnace at relatively low temperatures (900oC, far below the temperature required in the conventional volatilization method). This is followed by cooling the volatile PMG chloride product converting it into solid phase metal.

 

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  • Prof. Igor Lubomirsky
  • Prof. Igor Lubomirsky
1745
Cancer is a leading cause of death in the developed countries. It is a highly heterogeneous disease even among patients with the same type and grade of cancer. Thus, drug development for cancer is extremely challenging. However there are some consistencies; most tumor cells exhibit genomic instability...

Cancer is a leading cause of death in the developed countries. It is a highly heterogeneous disease even among patients with the same type and grade of cancer. Thus, drug development for cancer is extremely challenging. However there are some consistencies; most tumor cells exhibit genomic instability with an increased expression of oncogenes and inactivation of tumor suppressor genes.
P53 is a key tumor suppressor that is mutated in more than half of the human cancers. Over the years several mouse models were developed in order to study p53 mutations. Interestingly it has been shown that mice homozygous for mutant p53 are viable, and develop malignant tumors only in adulthood.
Prof. Rotter and her team revealed the mechanism by which embryos are protected from mutant p53-induced transformation. They found, using embryos stem cells (ESCs), that the conformation of mutant p53 in ESCs is stabilized to a WT conformation. They further identified the network of proteins that may shift p53 transformation to its WT form.
This technology presents methods (compositions and kits) of stabilizing mutant p53 in ESCs by interacting proteins, thus propose a novel cancer therapy.

Applications


  • Cancer

Advantages


  • Targeted for p53
  • Safe

Technology's Essence


The researchers  hypothesized that cellular factors in the pluripotent cells contribute the stabilization of the WT conformation of p53. They used a mass spectrometry (MS)-based interactome analysis to examind the interaction network of the different conformations of p53 in WT and Mut ESCs compared with somatic cells from the spleen. They immunoprecipitated WT and Mut conformation of p53 and used p53 KO cells as controls for background binding. Importantly, they identifies chromatic-specific proteomic network that is suggested to bind p53 and act as a stabilizer of Mut p53 into a WT conformation. This network (59 proteins) includes the CCT complex, USP7, Aurora kinase, Nedd4, and trim24. Interactions with this network enables the activation of WT activity of p53 and eliminates the gain-of function Mut activities, despite the p53 mutation.
Overall this is a proposed mechanism of rescuing ESCs cells from transformation which sets the basis for future p53-targeted cancer therapeutics. 

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  • Prof. Varda Rotter
1696
A new method for observing large areas with physically small detectors, which are unable to cover the whole area simultaneously, based on multiplexing several scanned areas onto a single detector unit followed by algorithmic reconstruction of the true field of view. Astronomical observations require...

A new method for observing large areas with physically small detectors, which are unable to cover the whole area simultaneously, based on multiplexing several scanned areas onto a single detector unit followed by algorithmic reconstruction of the true field of view.
Astronomical observations require the ability to detect very weak signals at high spatial resolution. This reflects on the special characteristics of the observation systems; they need to have a large aperture, high resolution detectors and very low system noise. These demands render high costs and complexity.
Our multiplexing and reconstructing method was developed based on the sparse nature of astronomical observations, and it could be implemented in any application in which sporadic data points are to be found against a fixed (whether detailed or blank) background.

Applications


  • Highly efficient telescopes
  • Quick quality assurance systems – fault metrology
  • Implementation in microscopy

Advantages


  • Use of small size detectors
  • Ability to scan large fields (compared to detector size)
  • Maintaining high resolution
  • Significant shortening of scan time
  • Easily applicable to existing systems

Technology's Essence


The method was developed for astronomical observations in which the studied field is immense and the detector size is relatively small and limited. The invention consists of an optical system that directs light (IR, Vis, UV or other) from different locations in the sky to the focal plane of a telescope onto a specific single detector area, creating a multiplexed image in which several portions of the sky are presented collectively.
Such multiplexing is done on each detector unit area with a different set of sky loci.
A reconstruction algorithm was developed to construct sub-observations sets in a method that guarantees unique recovery of the original wide-field image even when objects overlap.

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  • Prof. Avishay Gal-Yam
1780
A method based on Fast Neutron Resonance Transmission (FNRT) radiography that enables determining weight percentages of oil and water in thick, intact cores taken from subterranean or underwater geological formations. As part of geological exploitation to find oil and water, cores are extracted and...

A method based on Fast Neutron Resonance Transmission (FNRT) radiography that enables determining weight percentages of oil and water in thick, intact cores taken from subterranean or underwater geological formations. As part of geological exploitation to find oil and water, cores are extracted and tested to determine oil/water content.
This new method allows determining such content rapidly, in non- destructive, specific and quantities analysis of the cores.

Applications


  • Determining the identity and proportions of substances of oil and water content and their distribution in inspected cores

Advantages


  • A non-destructive method which enables to determine the fluid content along the entire length of an intact core or aggregate of cores within their protective sleeves.
  • More comprehensive information and considerable saving of analysis time compared to conventional sampling methods.
    Suitable for all types of rocks including tight-shale rocks.
  • This method enables to measure the weight fraction of oil and water in the core regardless of the core shape, thickness or distribution.
  • The fluid weight fractions in the samples are determined independently, thus the ratio of oil-to-rock weight-ratio is independent of the water content.
  • Due to high penetration of fast neutrons, the method is suitable for screening intact thick rock cores (10-15 cm), for which alternative probes, such as X-rays or slow neutrons suffer limited penetration.

Technology's Essence


In order to map the oil and water content and their distribution, an aggregate of intact cores within their protective sleeves is positioned on a moving conveyor belt and scanned by a broad- energy, fast- neutron beam. The neutrons are detected by a spectroscopic fast neutron imaging detector. The map of neutron-transmission spectra in each pixel provides information of oil/water content and distribution in such cores. 

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  • Prof. Amos Breskin

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